Patient MICB genotype at residue 52 is associated with mortality and disease-free survival
| Patient MICB residue . | Residue (SNP) or 4-residue (SNP) haplotype . | Number . | Overall mortality HR (95% CI; P value) . | Relapse HR (95% CI; P value) . | Disease-free survival HR (95% CI; P value) . |
|---|---|---|---|---|---|
| Residue 52∗ | AspAsp (GG) | 1107 | 1.0 | 1.0 | 1.0 |
| AsnAsp (AG) | 463 | 1.01 (0.84-1.21; .93) | 1.06 (0.87-1.29; .57) | 1.08 (0.92-1.26; .37) | |
| AsnAsn (AA) | 52 | 1.83 (1.24-2.71; .002) | 1.41 (0.84-2.35; .19) | 1.74 (1.20-2.53; .004) | |
| 4-residue haplotype | Asp-Lys-Ile-Thr (GG-AA-CC-CC) | 403 | 1.0 | 1.0 | 1.0 |
| AG-AA-CC-CC | 268 | 0.89 (0.68-1.16; .39) | 0.92 (0.69-1.23; .59) | 0.96 (0.76-1.22; .75) | |
| Asn-Lys-Ile-Thr (AA-AA-CC-CC) | 51 | 1.88 (1.22-2.92; .005) | 1.20 (0.68-2.14; .53) | 1.64 (1.07-2.49; .02) |
| Patient MICB residue . | Residue (SNP) or 4-residue (SNP) haplotype . | Number . | Overall mortality HR (95% CI; P value) . | Relapse HR (95% CI; P value) . | Disease-free survival HR (95% CI; P value) . |
|---|---|---|---|---|---|
| Residue 52∗ | AspAsp (GG) | 1107 | 1.0 | 1.0 | 1.0 |
| AsnAsp (AG) | 463 | 1.01 (0.84-1.21; .93) | 1.06 (0.87-1.29; .57) | 1.08 (0.92-1.26; .37) | |
| AsnAsn (AA) | 52 | 1.83 (1.24-2.71; .002) | 1.41 (0.84-2.35; .19) | 1.74 (1.20-2.53; .004) | |
| 4-residue haplotype | Asp-Lys-Ile-Thr (GG-AA-CC-CC) | 403 | 1.0 | 1.0 | 1.0 |
| AG-AA-CC-CC | 268 | 0.89 (0.68-1.16; .39) | 0.92 (0.69-1.23; .59) | 0.96 (0.76-1.22; .75) | |
| Asn-Lys-Ile-Thr (AA-AA-CC-CC) | 51 | 1.88 (1.22-2.92; .005) | 1.20 (0.68-2.14; .53) | 1.64 (1.07-2.49; .02) |
SNP, single nucleotide polymorphism.
Residue 52: rs3131639 A (Asn)/G (Asp).