Donor-recipient mismatching for MICA Exon 5 STR is associated with lower mortality
| Group . | Number . | Overall mortality HR (95% CI; P value) . | Relapse HR (95% CI; P value) . | Disease-free survival HR (95% CI; P value) . |
|---|---|---|---|---|
| No STR GVH vector mismatch | 707 | 1.0 | 1.0 | 1.0 |
| STR GVH vector mismatch∗ | 865 | 0.71 (0.60-0.84; .00006) | 0.87 (0.72-1.04; .13) | 0.81 (0.69-0.94; .007) |
| Both residue 129 and STR-matched | 689 | 1.0 | 1.0 | 1.0 |
| Both residue 129 and STR-mismatched | 327 | 0.77 (0.62-0.96; .02) | 0.87 (0.68-1.11; .25) | 0.82 (0.67-1.00; .05) |
| Mismatched only at STR; matched at residue 129 | 534 | 0.66 (0.54-0.79; .00002) | 0.85 (0.69-1.05; .13) | 0.79 (0.67-0.94; .008) |
| Mismatched only at residue 129; matched at STR | 18 | 0.54 (0.22-1.32; .18) | 0.82 (0.33-2.05; .68) | 0.78 (0.38-1.60; .50) |
| Group . | Number . | Overall mortality HR (95% CI; P value) . | Relapse HR (95% CI; P value) . | Disease-free survival HR (95% CI; P value) . |
|---|---|---|---|---|
| No STR GVH vector mismatch | 707 | 1.0 | 1.0 | 1.0 |
| STR GVH vector mismatch∗ | 865 | 0.71 (0.60-0.84; .00006) | 0.87 (0.72-1.04; .13) | 0.81 (0.69-0.94; .007) |
| Both residue 129 and STR-matched | 689 | 1.0 | 1.0 | 1.0 |
| Both residue 129 and STR-mismatched | 327 | 0.77 (0.62-0.96; .02) | 0.87 (0.68-1.11; .25) | 0.82 (0.67-1.00; .05) |
| Mismatched only at STR; matched at residue 129 | 534 | 0.66 (0.54-0.79; .00002) | 0.85 (0.69-1.05; .13) | 0.79 (0.67-0.94; .008) |
| Mismatched only at residue 129; matched at STR | 18 | 0.54 (0.22-1.32; .18) | 0.82 (0.33-2.05; .68) | 0.78 (0.38-1.60; .50) |
Any GVH vector mismatch: unidirectional and bidirectional.