Table 3.

Factors associated with COVID-19 infection among BMT survivors

Risk factorsUnivariate analysisMultivariable analysis
HR ratio95% CIP valueaHR ratio95% CIP value
Age at study participation 
<65 y REF    
≥65 y 0.54 0.37-0.79 .002  
Race/ethnicity 
Non-Hispanic White REF  .03c REF  .08∗  
African American 1.49 0.77-2.87 .23 1.50 0.75-3.02 .25 
Hispanic 1.67 1.03-2.69 .04 1.56 0.95-2.57 .08 
Other 0.43 0.16-1.18 .10 0.47 0.17-1.29 .14 
Sex 
Female REF    
Male 0.87 0.60-1.24 .43  
Primary cancer 
Leukemia + lymphoma REF  .44 REF  .10 
PCD 1.31 0.86-2.00 .21 1.51 0.96-2.39 .08 
Other 0.96 0.46-1.98 .90 0.66 0.30-1.45 .30 
Contact with COVID–19 test positive individuals (family members/friends/at work) 
No REF   REF   
Yes 5.00 3.17-7.87 <.001 4.48 2.82-7.12 <.0001 
Always wears mask 
No REF   REF   
Yes 0.47 0.31-0.73 .001 0.49 0.31-0.77 .002 
Always stays 6 feet away 
No REF    
Yes 0.63 0.44-0.91 .01  
Always washes hand 
No REF    
Yes 1.06 0.74-1.52 .74  
Annual household income 
≥$75 000 REF    
<$75 000 1.34 0.92-1.95 .13  
Education 
≥College REF  .42∗   
<High school 1.38 0.85-2.24 .19  
High school/college 1.10 0.73-1.64 .65  
Have insurance 
No REF    
Yes 0.91 0.29-2.86 .87  
Chronic health conditions 
Grade 0-2 REF    
Grade 3-4 1.17 0.81-1.68 .40  
Employment 
Retired REF  .01∗  REF  .057∗  
Employed 1.84 1.19-2.84 .006 1.45 0.91-2.30 .12 
Not employed 2.14 1.28-3.59 .004 1.90 1.12-3.23 .02 
BMT type 
Autologous REF  .72∗   
Allogeneic without chronic GvHD 0.84 0.51-1.38 .49  
Allogeneic with chronic GvHD 0.87 0.56-1.35 .54  
BMT survivorsfollow-upyears 
≥20 y REF  .58∗   
<10 y 1.03 0.64-1.65 .92  
10-19 y 0.83 0.55-1.27 .40  
BMT survivors conditioning intensity 
Nonmyeloablative/reduced intensity REF    
Myeloablative conditioning 0.98 0.67-1.44 .91  
Disease status at BMT 
Standard risk REF    
High-risk 1.31 0.92-1.88 .13  
Risk factorsUnivariate analysisMultivariable analysis
HR ratio95% CIP valueaHR ratio95% CIP value
Age at study participation 
<65 y REF    
≥65 y 0.54 0.37-0.79 .002  
Race/ethnicity 
Non-Hispanic White REF  .03c REF  .08∗  
African American 1.49 0.77-2.87 .23 1.50 0.75-3.02 .25 
Hispanic 1.67 1.03-2.69 .04 1.56 0.95-2.57 .08 
Other 0.43 0.16-1.18 .10 0.47 0.17-1.29 .14 
Sex 
Female REF    
Male 0.87 0.60-1.24 .43  
Primary cancer 
Leukemia + lymphoma REF  .44 REF  .10 
PCD 1.31 0.86-2.00 .21 1.51 0.96-2.39 .08 
Other 0.96 0.46-1.98 .90 0.66 0.30-1.45 .30 
Contact with COVID–19 test positive individuals (family members/friends/at work) 
No REF   REF   
Yes 5.00 3.17-7.87 <.001 4.48 2.82-7.12 <.0001 
Always wears mask 
No REF   REF   
Yes 0.47 0.31-0.73 .001 0.49 0.31-0.77 .002 
Always stays 6 feet away 
No REF    
Yes 0.63 0.44-0.91 .01  
Always washes hand 
No REF    
Yes 1.06 0.74-1.52 .74  
Annual household income 
≥$75 000 REF    
<$75 000 1.34 0.92-1.95 .13  
Education 
≥College REF  .42∗   
<High school 1.38 0.85-2.24 .19  
High school/college 1.10 0.73-1.64 .65  
Have insurance 
No REF    
Yes 0.91 0.29-2.86 .87  
Chronic health conditions 
Grade 0-2 REF    
Grade 3-4 1.17 0.81-1.68 .40  
Employment 
Retired REF  .01∗  REF  .057∗  
Employed 1.84 1.19-2.84 .006 1.45 0.91-2.30 .12 
Not employed 2.14 1.28-3.59 .004 1.90 1.12-3.23 .02 
BMT type 
Autologous REF  .72∗   
Allogeneic without chronic GvHD 0.84 0.51-1.38 .49  
Allogeneic with chronic GvHD 0.87 0.56-1.35 .54  
BMT survivorsfollow-upyears 
≥20 y REF  .58∗   
<10 y 1.03 0.64-1.65 .92  
10-19 y 0.83 0.55-1.27 .40  
BMT survivors conditioning intensity 
Nonmyeloablative/reduced intensity REF    
Myeloablative conditioning 0.98 0.67-1.44 .91  
Disease status at BMT 
Standard risk REF    
High-risk 1.31 0.92-1.88 .13  
∗

P value for whole group. Bold values indicate significant associations.

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