Univariable and multivariable cox regression of OS-SEER cohorts 1 and 2
| Patient variables . | UVA . | MVA . | ||
|---|---|---|---|---|
| Hazard ratio (95% CI) . | P value . | Hazard ratio (95% CI) . | P value . | |
| SEER cohort 1∗ | ||||
| Age, 5-y older | 1.47 (1.45-1.48) | <.0001 | 1.47 (1.46-1.48) | <.0001 |
| Sex–male vs female | 1.13 (1.10-1.17) | <.0001 | 1.35 (1.31-1.39) | <.0001 |
| Year of diagnosis (vs 2014 and after) Before 2014 | 1.10 (1.06-1.14) | <.0001 | 1.09 (1.06-1.13) | <.0001 |
| Race (vs White) | ||||
| Black | 1.20 (1.14-1.27) | <.0001 | 1.51 (1.43-1.59) | <.0001 |
| Asian or Pacific Islander | 0.89 (0.81-0.99) | .03 | 1.02 (0.92-1.13) | .68 |
| American Indian/Alaska Native | 0.92 (0.71-1.20) | .55 | 1.22 (0.94-1.590) | .14 |
| Ethnicity–Hispanic vs Non-Hispanic | 0.98 (0.91-1.04) | .45 | 1.17 (1.09-1.25) | <.0001 |
| Malignancy diagnosed before CLL vs no | 1.74 (1.68-1.79) | <.0001 | 1.21 (1.17-1.25) | <.0001 |
| SEER cohort 2† | ||||
| Age, 5-y older | 1.49 (1.48-1.51) | <.0001 | 1.51 (1.49-1.52) | <.0001 |
| Sex–male vs female | 1.09 (1.05-1.13) | <.0001 | 1.33 (1.28-1.37) | <.0001 |
| Year of diagnosis (vs 2014 and after) Before 2014 | 1.13 (1.06-1.19) | <.0001 | 1.08 (1.02-1.15) | .0071 |
| Race (vs White) | ||||
| Black | 1.27 (1.19-1.34) | <.0001 | 1.33 (1.25-1.42) | <.0001 |
| Asian or Pacific Islander | 0.85 (0.76-0.95) | .006 | 0.97 (0.86-1.09) | .60 |
| American Indian/Alaska Native | 1.05 (0.78-1.41) | .75 | 1.41 (1.04-1.93) | .03 |
| Ethnicity–Hispanic vs Non-Hispanic | 0.96 (0.89-1.03) | .24 | 1.08 (1.00-0.17) | .05 |
| Yost vs group 3 | ||||
| Group 1 | 1.57 (1.51-1.64) | <.0001 | 1.48 (1.41-1.54) | <.0001 |
| Group 2 | 1.26 (1.21-1.31) | <.0001 | 1.21 (1.16-1.26) | <.0001 |
| Rural-urban commuting area rural vs urban | 1.19 (1.12-1.25) | <.0001 | 0.97 (0.92-1.03) | .32 |
| Patient variables . | UVA . | MVA . | ||
|---|---|---|---|---|
| Hazard ratio (95% CI) . | P value . | Hazard ratio (95% CI) . | P value . | |
| SEER cohort 1∗ | ||||
| Age, 5-y older | 1.47 (1.45-1.48) | <.0001 | 1.47 (1.46-1.48) | <.0001 |
| Sex–male vs female | 1.13 (1.10-1.17) | <.0001 | 1.35 (1.31-1.39) | <.0001 |
| Year of diagnosis (vs 2014 and after) Before 2014 | 1.10 (1.06-1.14) | <.0001 | 1.09 (1.06-1.13) | <.0001 |
| Race (vs White) | ||||
| Black | 1.20 (1.14-1.27) | <.0001 | 1.51 (1.43-1.59) | <.0001 |
| Asian or Pacific Islander | 0.89 (0.81-0.99) | .03 | 1.02 (0.92-1.13) | .68 |
| American Indian/Alaska Native | 0.92 (0.71-1.20) | .55 | 1.22 (0.94-1.590) | .14 |
| Ethnicity–Hispanic vs Non-Hispanic | 0.98 (0.91-1.04) | .45 | 1.17 (1.09-1.25) | <.0001 |
| Malignancy diagnosed before CLL vs no | 1.74 (1.68-1.79) | <.0001 | 1.21 (1.17-1.25) | <.0001 |
| SEER cohort 2† | ||||
| Age, 5-y older | 1.49 (1.48-1.51) | <.0001 | 1.51 (1.49-1.52) | <.0001 |
| Sex–male vs female | 1.09 (1.05-1.13) | <.0001 | 1.33 (1.28-1.37) | <.0001 |
| Year of diagnosis (vs 2014 and after) Before 2014 | 1.13 (1.06-1.19) | <.0001 | 1.08 (1.02-1.15) | .0071 |
| Race (vs White) | ||||
| Black | 1.27 (1.19-1.34) | <.0001 | 1.33 (1.25-1.42) | <.0001 |
| Asian or Pacific Islander | 0.85 (0.76-0.95) | .006 | 0.97 (0.86-1.09) | .60 |
| American Indian/Alaska Native | 1.05 (0.78-1.41) | .75 | 1.41 (1.04-1.93) | .03 |
| Ethnicity–Hispanic vs Non-Hispanic | 0.96 (0.89-1.03) | .24 | 1.08 (1.00-0.17) | .05 |
| Yost vs group 3 | ||||
| Group 1 | 1.57 (1.51-1.64) | <.0001 | 1.48 (1.41-1.54) | <.0001 |
| Group 2 | 1.26 (1.21-1.31) | <.0001 | 1.21 (1.16-1.26) | <.0001 |
| Rural-urban commuting area rural vs urban | 1.19 (1.12-1.25) | <.0001 | 0.97 (0.92-1.03) | .32 |
SEER Program (www.seer.cancer.gov) SEER∗Stat Database: Incidence-SEER Research Plus Data, 17 Registries, Nov 2021 Sub (2000-2019)-Linked To County Attributes-Time Dependent (1990-2019) Income/Rurality, 1969 to 2020 Counties, National Cancer Institute, DCCPS, Surveillance Research Program, released April 2022, based on the November 2021 submission.
SEER Program (www.seer.cancer.gov) SEER∗Stat Database: Incidence - SEER 18 Regs (Excl AK) Custom Data (with additional treatment fields), Nov 2018 Sub (2000-2016) <Vintage 2016 Pops by Tract 2000/2010 Mixed Geographies> - Linked To Census Tract Attributes - Time Dependent (2000-2016) - SEER 18 (excl AK) Census 2000/2010 Geographies with Index Field Quantiles, National Cancer Institute, DCCPS, Surveillance Research Program, released January 2020, based on the November 2018 submission.