Baseline characteristics of the SPRING trial participants based on survival status at follow-up (n = 431)
| Characteristics∗ . | Survived (n = 407) . | Died (n = 24) . | P value† . |
|---|---|---|---|
| Age at enrollment, median (IQR) | 7.7 (6.0-10.1) | 7.5 (6.3-9.0) | .778 |
| Female | 211 (51.8) | 13 (54.2) | .825 |
| Total hemoglobin (g/dL), median (IQR) | 7.3 (6.7-8.1) | 7.2 (6.4-7.2) | .547 |
| White blood cell count (103/mm3), median (IQR) | 13.5 (11.2-16.9) | 14.1 (12.5-17.3) | .580 |
| Transcranial Doppler velocity at screening (cm/s), median (IQR) | 200.0 (130.0-206.0) | 203.5 (146.3-219.0) | .113 |
| Height (cm) | 118.5 (11.8) | 115.1 (10.9) | .168 |
| Weight (kg) | 19.2 (4.5) | 17.3 (3.7) | .038 |
| BMI (kg/m2) | 13.6 (1.5) | 13.0 (1.6) | .070 |
| Height-for-age z score | −1.5 (1.3) | −1.8 (1.2) | .186 |
| Weight-for-age z score | −2.1 (1.1) | −2.6 (1.2) | .016 |
| BMI z score | −1.9 (1.3) | −2.2 (1.6) | .161 |
| Characteristics∗ . | Survived (n = 407) . | Died (n = 24) . | P value† . |
|---|---|---|---|
| Age at enrollment, median (IQR) | 7.7 (6.0-10.1) | 7.5 (6.3-9.0) | .778 |
| Female | 211 (51.8) | 13 (54.2) | .825 |
| Total hemoglobin (g/dL), median (IQR) | 7.3 (6.7-8.1) | 7.2 (6.4-7.2) | .547 |
| White blood cell count (103/mm3), median (IQR) | 13.5 (11.2-16.9) | 14.1 (12.5-17.3) | .580 |
| Transcranial Doppler velocity at screening (cm/s), median (IQR) | 200.0 (130.0-206.0) | 203.5 (146.3-219.0) | .113 |
| Height (cm) | 118.5 (11.8) | 115.1 (10.9) | .168 |
| Weight (kg) | 19.2 (4.5) | 17.3 (3.7) | .038 |
| BMI (kg/m2) | 13.6 (1.5) | 13.0 (1.6) | .070 |
| Height-for-age z score | −1.5 (1.3) | −1.8 (1.2) | .186 |
| Weight-for-age z score | −2.1 (1.1) | −2.6 (1.2) | .016 |
| BMI z score | −1.9 (1.3) | −2.2 (1.6) | .161 |
IQR, interquartile range; SD, standard deviation.
The therapy group comprised of children with abnormal transcranial Doppler velocities on hydroxyurea therapy, and the comparison group was children with nonelevated transcranial Doppler velocities.
Mean (SD) for continuous variables and counts (percentages) for categorical variables, unless otherwise noted.
χ2 test for counts, t test for means, Mann-Whitney U test for medians.