Table 1. Analysis of biological samples... | American Society of Hematology

Table 1.

Analysis of biological samples collected from SCD mice after transplantation of KLF1-GATA1–expressing SCD mouse HSCs

Transplant group	n	Peripheral blood						Spleen	Urine
Transplant group	n	RBCs, ×10⁶/μL	Hb, g/dL	WBCs, ×10³/μL	Hematocrit, %	HbA2, %	Reticulocytes, %	Weight, g	Osmolarity, mOsm/kg
Mock mice	11	5.73 ± 1.24	6.48 ± 1.45	14.89 ± 6.45	26.25 ± 7.56	4.14 ± 1.55	50.47 ± 6.33	1.14 ± 0.25	1462 ± 236
KG-M mice	11	9.86 ± 1.71∗∗	11.61 ± 2.93∗∗	9.86 ± 4.80∗	39.34 ± 5.97∗∗	18.81 ± 3.85∗∗	21.45 ± 7.16∗∗	0.75 ± 0.10∗∗	2663 ± 305∗∗
KG-L mice	10	7.16 ± 0.62∗∗	7.84 ± 1.00∗	15.71 ± 6.14	31.96 ± 3.34∗	11.47 ± 1.11∗∗	32.56 ± 7.41∗∗	0.90 ± 0.20∗	1985 ± 326∗∗

Transplant group	n	Peripheral blood						Spleen	Urine
Transplant group	n	RBCs, ×10⁶/μL	Hb, g/dL	WBCs, ×10³/μL	Hematocrit, %	HbA2, %	Reticulocytes, %	Weight, g	Osmolarity, mOsm/kg
Mock mice	11	5.73 ± 1.24	6.48 ± 1.45	14.89 ± 6.45	26.25 ± 7.56	4.14 ± 1.55	50.47 ± 6.33	1.14 ± 0.25	1462 ± 236
KG-M mice	11	9.86 ± 1.71∗∗	11.61 ± 2.93∗∗	9.86 ± 4.80∗	39.34 ± 5.97∗∗	18.81 ± 3.85∗∗	21.45 ± 7.16∗∗	0.75 ± 0.10∗∗	2663 ± 305∗∗
KG-L mice	10	7.16 ± 0.62∗∗	7.84 ± 1.00∗	15.71 ± 6.14	31.96 ± 3.34∗	11.47 ± 1.11∗∗	32.56 ± 7.41∗∗	0.90 ± 0.20∗	1985 ± 326∗∗

Data are presented as means ± standard deviation.

Hb, total Hb concentration; RBCs, red blood cells; WBCs, white blood cells.

P < .05; ∗∗P < 0.01 vs mock mice.