Details of prophylactic doses and treatment for postoperative bleeds in patients undergoing minor surgeries or procedures
| . | PwHA with FVIII inhibitors (n = 64) rFVIIa . | PwHA without FVIII inhibitors (n = 51) . | |
|---|---|---|---|
| SHL FVIII . | EHL FVIII . | ||
| Dental | |||
| Procedures, n | 29 | 33 | |
| Procedures managed with additional prophylactic factor concentrate, n (%) | 5 (17.2) | 14 (42.4) | 2 (6.1) |
| Procedures associated with a single dose of factor concentrate, n (%)∗ | 4 (80.0) | 11 (78.6) | 2 (100) |
| Median prophylactic doses per surgery (range) | 1.0 (1-3) | 1.0 (1-3) | 1.0 (1-1) |
| Median prophylactic cumulative dose per surgery (IQR) | 83.4 μg/kg (83.4-106.8) | 25.4 IU/kg (24.8-38.9) | 42.1 IU/kg (36.8-47.4) |
| Procedures associated with treatment for postoperative bleeds, n (%) | 6 (20.7) | 6 (18.2) | 2 (6.1) |
| Median days postoperative bleeds were treated (range) | 1.5 (1-4) | 2.0 (1-2) | 1.0 (1-1) |
| CVAD | |||
| Procedures, n | 35 | 1 | |
| Procedures managed with additional prophylactic factor concentrate, n (%) | 9 (25.7) | 0 | 0 |
| Procedures associated with a single dose of factor concentrate, n (%)∗ | 6 (66.7) | — | — |
| Median prophylactic doses per surgery (range) | 1.0 (1-3) | — | — |
| Median prophylactic cumulative dose per surgery (IQR) | 119.0 μg/kg (86.5-168.7) | — | — |
| Procedures associated with treatment for postoperative bleeds, n (%) | 3 (8.6) | 0 (0.0) | 0 (0.0) |
| Median days postoperative bleeds were treated (range) | 1.0 (1-3) | — | — |
| Endoscopic | |||
| Procedures, n | 13 | 17 | |
| Procedures managed with additional prophylactic factor concentrate, n (%) | 2 (15.4) | 10 (58.8) | 1 (5.9) |
| Procedures associated with a single dose of factor concentrate, n (%)∗ | 1 (50.0) | 6 (60.0) | 0 |
| Median prophylactic doses per surgery (range) | 1.5 (1-2) | 1.0 (1-12) | 3.0 |
| Median prophylactic cumulative dose per surgery (IQR) | 90.3 μg/kg (62.0-118.6) | 30.0 IU/kg (23.3-52.4) | 122.4 IU/kg |
| Procedures associated with treatment for postoperative bleeds, n (%) | 0 | 0 | 0 |
| Median days postoperative bleeds were treated (range) | — | — | — |
| Joint | |||
| Procedures, n | 3 | 22 | |
| Procedures managed with additional prophylactic factor concentrate, n (%) | 2 (66.7) | 9 (40.9) | 2 (9.1) |
| Procedures associated with a single dose of factor concentrate, n (%)∗ | 1 (50.0) | 9 (100) | 2 (100) |
| Median prophylactic doses per surgery (range) | 1.5 (1-2) | 1.0 (1-1) | 1.0 (1-1) |
| Median prophylactic cumulative dose per surgery (IQR) | 156.2 μg/kg (85.1-227.3) | 21.2 IU/kg (21.1-29.8) | 21.3 IU/kg (20.3-22.4) |
| Procedures associated with treatment for postoperative bleeds, n (%) | 0 | 1 (4.5) | 0 (0.0) |
| Median days postoperative bleeds were treated (range) | — | 10.0 (10-10) | — |
| Other | |||
| Procedures, n | 27 | 35 | |
| Procedures managed with additional prophylactic factor concentrate, n (%) | 3 (11.1) | 13 (37.1) | 0 |
| Procedures associated with a single dose of factor concentrate, n (%)∗ | 1 (33.3) | 7 (53.8) | — |
| Median prophylactic doses per surgery (range) | 2.0 (1-2) | 1.0 (1-14) | — |
| Median prophylactic cumulative dose per surgery (IQR) | 78.2 μg/kg (62.4-154.8) | 42.6 IU/kg (33.3-138.2) | — |
| Procedures associated with treatment for postoperative bleeds, n (%) | 0 | 4 (11.4) | 0 |
| Median days postoperative bleeds were treated (range) | — | 1.0 (1-9) | — |
| . | PwHA with FVIII inhibitors (n = 64) rFVIIa . | PwHA without FVIII inhibitors (n = 51) . | |
|---|---|---|---|
| SHL FVIII . | EHL FVIII . | ||
| Dental | |||
| Procedures, n | 29 | 33 | |
| Procedures managed with additional prophylactic factor concentrate, n (%) | 5 (17.2) | 14 (42.4) | 2 (6.1) |
| Procedures associated with a single dose of factor concentrate, n (%)∗ | 4 (80.0) | 11 (78.6) | 2 (100) |
| Median prophylactic doses per surgery (range) | 1.0 (1-3) | 1.0 (1-3) | 1.0 (1-1) |
| Median prophylactic cumulative dose per surgery (IQR) | 83.4 μg/kg (83.4-106.8) | 25.4 IU/kg (24.8-38.9) | 42.1 IU/kg (36.8-47.4) |
| Procedures associated with treatment for postoperative bleeds, n (%) | 6 (20.7) | 6 (18.2) | 2 (6.1) |
| Median days postoperative bleeds were treated (range) | 1.5 (1-4) | 2.0 (1-2) | 1.0 (1-1) |
| CVAD | |||
| Procedures, n | 35 | 1 | |
| Procedures managed with additional prophylactic factor concentrate, n (%) | 9 (25.7) | 0 | 0 |
| Procedures associated with a single dose of factor concentrate, n (%)∗ | 6 (66.7) | — | — |
| Median prophylactic doses per surgery (range) | 1.0 (1-3) | — | — |
| Median prophylactic cumulative dose per surgery (IQR) | 119.0 μg/kg (86.5-168.7) | — | — |
| Procedures associated with treatment for postoperative bleeds, n (%) | 3 (8.6) | 0 (0.0) | 0 (0.0) |
| Median days postoperative bleeds were treated (range) | 1.0 (1-3) | — | — |
| Endoscopic | |||
| Procedures, n | 13 | 17 | |
| Procedures managed with additional prophylactic factor concentrate, n (%) | 2 (15.4) | 10 (58.8) | 1 (5.9) |
| Procedures associated with a single dose of factor concentrate, n (%)∗ | 1 (50.0) | 6 (60.0) | 0 |
| Median prophylactic doses per surgery (range) | 1.5 (1-2) | 1.0 (1-12) | 3.0 |
| Median prophylactic cumulative dose per surgery (IQR) | 90.3 μg/kg (62.0-118.6) | 30.0 IU/kg (23.3-52.4) | 122.4 IU/kg |
| Procedures associated with treatment for postoperative bleeds, n (%) | 0 | 0 | 0 |
| Median days postoperative bleeds were treated (range) | — | — | — |
| Joint | |||
| Procedures, n | 3 | 22 | |
| Procedures managed with additional prophylactic factor concentrate, n (%) | 2 (66.7) | 9 (40.9) | 2 (9.1) |
| Procedures associated with a single dose of factor concentrate, n (%)∗ | 1 (50.0) | 9 (100) | 2 (100) |
| Median prophylactic doses per surgery (range) | 1.5 (1-2) | 1.0 (1-1) | 1.0 (1-1) |
| Median prophylactic cumulative dose per surgery (IQR) | 156.2 μg/kg (85.1-227.3) | 21.2 IU/kg (21.1-29.8) | 21.3 IU/kg (20.3-22.4) |
| Procedures associated with treatment for postoperative bleeds, n (%) | 0 | 1 (4.5) | 0 (0.0) |
| Median days postoperative bleeds were treated (range) | — | 10.0 (10-10) | — |
| Other | |||
| Procedures, n | 27 | 35 | |
| Procedures managed with additional prophylactic factor concentrate, n (%) | 3 (11.1) | 13 (37.1) | 0 |
| Procedures associated with a single dose of factor concentrate, n (%)∗ | 1 (33.3) | 7 (53.8) | — |
| Median prophylactic doses per surgery (range) | 2.0 (1-2) | 1.0 (1-14) | — |
| Median prophylactic cumulative dose per surgery (IQR) | 78.2 μg/kg (62.4-154.8) | 42.6 IU/kg (33.3-138.2) | — |
| Procedures associated with treatment for postoperative bleeds, n (%) | 0 | 4 (11.4) | 0 |
| Median days postoperative bleeds were treated (range) | — | 1.0 (1-9) | — |
Percentages are of the number of procedures associated with additional prophylaxis.