Clinicopathologic characteristics and results of immunohistochemistries of patients of the training cohort (N = 238)
| . | Number (%) . | CD8 number . | CD8 ratio . | CD68 number . | CD68 ratio . | CD47-low . | CD47-high . | P . | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Mean . | P . | Mean . | P . | Mean . | P . | Mean . | P . | Number (%) . | Number (%) . | ||||
| Sex | Male | 149 (62.6) | 823.3 | .204 | 23.0 | .156 | 743.0 | .562 | 19.4 | .454 | 121 (81.2) | 28 (18.8) | .195 |
| Female | 89 (37.4) | 671.1 | 18.6 | 796.7 | 21.0 | 78 (87.6) | 11 (12.4) | ||||||
| Age, y | <60 | 117 (49.2) | 787.0 | .722 | 22.0 | .411 | 777.4 | .729 | 20.0 | .953 | 100 (85.5) | 17 (14.5) | .447 |
| ≥60 | 121 (50.8) | 745.5 | 20.8 | 746.8 | 19.9 | 99 (81.8) | 22 (18.2) | ||||||
| Diagnosis | DLBCL NOS | 166 (69.7) | 766.0 | <.001∗ | 20.8 | <.001∗ | 675.2 | <.001 | 17.9 | <.001∗ | 128 (77.1) | 38 (22.9) | .004 |
| PCNSL | 41 (17.2) | 400.1 | 13.2 | 591.3 | 18.0 | 40 (97.6) | 1 (2.4) | ||||||
| PMLBL | 10 (4.2) | 1405.6 | 38.4 | 1164.0 | 38.6 | 10 (100) | 0 (0.0) | ||||||
| EBV DLBCL | 9 (3.8) | 895.6 | 28.5 | 1629.0 | 36.5 | 9 (100) | 0 (0.0) | ||||||
| THRLBL | 6 (2.5) | 2116.7 | 53.1 | 1976.2 | 41.2 | 6 (100) | 0 (0.0) | ||||||
| IVLBL | 6 (2.5) | N/A | N/A | N/A | N/A | 6 (100) | 0 (0.0) | ||||||
| Cell of origin (in DLBCL NOS) | GCB | 56 (34.4) | 755.5 | .875 | 20.2 | .781 | 675.6 | .880 | 18.6 | .752 | 51 (91.1) | 5 (8.9) | .002 |
| Non-GCB | 107 (65.6) | 778.8 | 21.3 | 688.7 | 17.8 | 74 (69.2) | 33 (30.8) | ||||||
| Ann Arbor stage | I-II | 157 (66.0) | 624.8 | .003 | 18.1 | .009 | 691.5 | .040 | 18.8 | .180 | 127 (80.9) | 30 (19.1) | .114 |
| III-IV | 81 (34.0) | 996.6 | 26.7 | 878.2 | 21.7 | 72 (88.9) | 9 (11.1) | ||||||
| Organ | Intestine | 58 (24.4) | 376.0 | <.001∗ | 10.6 | <.001∗ | 599.0 | .155∗ | 16.8 | .374∗ | 34 (58.6) | 24 (41.4) | <.001 |
| LN | 56 (23.5) | 1062.9 | 27.6 | 877.7 | 21.0 | 50 (89.3) | 6 (10.7) | ||||||
| Other sites | 53 (22.3) | 788.0 | 20.5 | 736.5 | 19.5 | 45 (84.9) | 8 (15.1) | ||||||
| Brain | 45 (18.9) | 421.3 | 14.0 | 648.9 | 18.5 | 44 (97.8) | 1 (2.2) | ||||||
| Testis | 9 (3.8) | 1179.5 | 36.5 | 704.6 | 16.8 | 9 (100) | 0 (0.0) | ||||||
| Mediastinum | 9 (3.8) | 1480.1 | 41.1 | 1164.0 | 28.6 | 9 (100) | 0 (0.0) | ||||||
| Spleen | 8 (3.4) | 388.3 | 18.8 | 766.4 | 24.4 | 8 (100) | 0 (0.0) | ||||||
| . | Number (%) . | CD8 number . | CD8 ratio . | CD68 number . | CD68 ratio . | CD47-low . | CD47-high . | P . | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Mean . | P . | Mean . | P . | Mean . | P . | Mean . | P . | Number (%) . | Number (%) . | ||||
| Sex | Male | 149 (62.6) | 823.3 | .204 | 23.0 | .156 | 743.0 | .562 | 19.4 | .454 | 121 (81.2) | 28 (18.8) | .195 |
| Female | 89 (37.4) | 671.1 | 18.6 | 796.7 | 21.0 | 78 (87.6) | 11 (12.4) | ||||||
| Age, y | <60 | 117 (49.2) | 787.0 | .722 | 22.0 | .411 | 777.4 | .729 | 20.0 | .953 | 100 (85.5) | 17 (14.5) | .447 |
| ≥60 | 121 (50.8) | 745.5 | 20.8 | 746.8 | 19.9 | 99 (81.8) | 22 (18.2) | ||||||
| Diagnosis | DLBCL NOS | 166 (69.7) | 766.0 | <.001∗ | 20.8 | <.001∗ | 675.2 | <.001 | 17.9 | <.001∗ | 128 (77.1) | 38 (22.9) | .004 |
| PCNSL | 41 (17.2) | 400.1 | 13.2 | 591.3 | 18.0 | 40 (97.6) | 1 (2.4) | ||||||
| PMLBL | 10 (4.2) | 1405.6 | 38.4 | 1164.0 | 38.6 | 10 (100) | 0 (0.0) | ||||||
| EBV DLBCL | 9 (3.8) | 895.6 | 28.5 | 1629.0 | 36.5 | 9 (100) | 0 (0.0) | ||||||
| THRLBL | 6 (2.5) | 2116.7 | 53.1 | 1976.2 | 41.2 | 6 (100) | 0 (0.0) | ||||||
| IVLBL | 6 (2.5) | N/A | N/A | N/A | N/A | 6 (100) | 0 (0.0) | ||||||
| Cell of origin (in DLBCL NOS) | GCB | 56 (34.4) | 755.5 | .875 | 20.2 | .781 | 675.6 | .880 | 18.6 | .752 | 51 (91.1) | 5 (8.9) | .002 |
| Non-GCB | 107 (65.6) | 778.8 | 21.3 | 688.7 | 17.8 | 74 (69.2) | 33 (30.8) | ||||||
| Ann Arbor stage | I-II | 157 (66.0) | 624.8 | .003 | 18.1 | .009 | 691.5 | .040 | 18.8 | .180 | 127 (80.9) | 30 (19.1) | .114 |
| III-IV | 81 (34.0) | 996.6 | 26.7 | 878.2 | 21.7 | 72 (88.9) | 9 (11.1) | ||||||
| Organ | Intestine | 58 (24.4) | 376.0 | <.001∗ | 10.6 | <.001∗ | 599.0 | .155∗ | 16.8 | .374∗ | 34 (58.6) | 24 (41.4) | <.001 |
| LN | 56 (23.5) | 1062.9 | 27.6 | 877.7 | 21.0 | 50 (89.3) | 6 (10.7) | ||||||
| Other sites | 53 (22.3) | 788.0 | 20.5 | 736.5 | 19.5 | 45 (84.9) | 8 (15.1) | ||||||
| Brain | 45 (18.9) | 421.3 | 14.0 | 648.9 | 18.5 | 44 (97.8) | 1 (2.2) | ||||||
| Testis | 9 (3.8) | 1179.5 | 36.5 | 704.6 | 16.8 | 9 (100) | 0 (0.0) | ||||||
| Mediastinum | 9 (3.8) | 1480.1 | 41.1 | 1164.0 | 28.6 | 9 (100) | 0 (0.0) | ||||||
| Spleen | 8 (3.4) | 388.3 | 18.8 | 766.4 | 24.4 | 8 (100) | 0 (0.0) | ||||||
CD8 and CD68, Student t test and 1-way analysis of variance test; CD47, Pearson’s χ2 test.