Impact of TMTV, ECOG-PS, IPI, and combined TMTV/ECOG-PS for survival (PFS and OS) in the PETAL, GOYA, and RW series
| Variables and index . | PETAL, HR (95% CI), P value . | GOYA, HR (95% CI), P value . | RW, HR (95% CI), P value . | |||
|---|---|---|---|---|---|---|
| PFS . | OS . | PFS . | OS . | PFS . | OS . | |
| ECOG-PS ≥2 | 1.94 (1.30-3.00), .006 | 2.46 (1.50-4.00), <.001 | 1.75 (1.37-2.22), <.001 | 1.95 (1.47-259), <0.001 | 2.18 (1.50-3.10), <.001 | 2.61 (1.80-3.80), <.001 |
| TMTV >220 cm3 | 2.88 (2.10-4.00), <.001 | 2.69 (1.80-4.00), <.001 | 1.75 (1.43-2.14), <.001 | 1.84 (1.42-2.38), <.001 | 2.73 (1.90-3.80), <.001 | 2.80 (1.90-4.10), <.001 |
| IPI 3-5 | 2.33 (1.70-3.20), <.001 | 2.41 (1.70-3.50), <.001 | 1.81 (1.50-2.2), <.001 | 2.1 (1.70-2.60), <.001 | 2.42 (1.70-3.50), <.001 | 3.23 (2.10-5.00), <.001 |
| Combined TMTV/ECOG-PS∗ | ||||||
| 1 risk factor | 2.92 (2.00-4.20), <.001 | 2.71 (1.80-4.20), <.001 | 1.47 (1.18-1.82), .00493 | 1.46 (1.11-1.92), .00683 | 2.37 (1.60-3.50), <.001 | 2.24 (1.40-3.50), <.001 |
| 2 risk factors | 3.32 (2.00-5.50), <.001 | 3.85 (2.20-6.80), <.001 | 2.85 (2.11-3.84), <.001 | 3.35 (2.34-4.78), <.001 | 3.85 (2.50-5.90), <.001 | 4.61 (2.90-7.30), <.001 |
| Variables and index . | PETAL, HR (95% CI), P value . | GOYA, HR (95% CI), P value . | RW, HR (95% CI), P value . | |||
|---|---|---|---|---|---|---|
| PFS . | OS . | PFS . | OS . | PFS . | OS . | |
| ECOG-PS ≥2 | 1.94 (1.30-3.00), .006 | 2.46 (1.50-4.00), <.001 | 1.75 (1.37-2.22), <.001 | 1.95 (1.47-259), <0.001 | 2.18 (1.50-3.10), <.001 | 2.61 (1.80-3.80), <.001 |
| TMTV >220 cm3 | 2.88 (2.10-4.00), <.001 | 2.69 (1.80-4.00), <.001 | 1.75 (1.43-2.14), <.001 | 1.84 (1.42-2.38), <.001 | 2.73 (1.90-3.80), <.001 | 2.80 (1.90-4.10), <.001 |
| IPI 3-5 | 2.33 (1.70-3.20), <.001 | 2.41 (1.70-3.50), <.001 | 1.81 (1.50-2.2), <.001 | 2.1 (1.70-2.60), <.001 | 2.42 (1.70-3.50), <.001 | 3.23 (2.10-5.00), <.001 |
| Combined TMTV/ECOG-PS∗ | ||||||
| 1 risk factor | 2.92 (2.00-4.20), <.001 | 2.71 (1.80-4.20), <.001 | 1.47 (1.18-1.82), .00493 | 1.46 (1.11-1.92), .00683 | 2.37 (1.60-3.50), <.001 | 2.24 (1.40-3.50), <.001 |
| 2 risk factors | 3.32 (2.00-5.50), <.001 | 3.85 (2.20-6.80), <.001 | 2.85 (2.11-3.84), <.001 | 3.35 (2.34-4.78), <.001 | 3.85 (2.50-5.90), <.001 | 4.61 (2.90-7.30), <.001 |
CI, confidence interval; HR, hazard ratio.
Risk factors are TMTV >220 cm3 and ECOG-PS ≥2.