Risk factors associated with the prospective rate of priapism in men with sickle cell anemia
| Characteristic . | Priapism rate (95% CI) . | P value∗ . |
|---|---|---|
| Retrospective and prospective priapism rates, events per year (n = 73) | <.001 | |
| Retrospective from history (n = 73) | 23.6 (22.5-24.8) | |
| Prospective from diary (n = 71) | 16.8 (14.9-18.8) | |
| Monthly priapism rate by experiencing major priapism in prospective period | <.001 | |
| No major priapism (n = 53) | 1.2 (1.0-1.3) | |
| At least one major priapism (n = 18) | 2.1 (1.8-2.5) | |
| Monthly priapism rate by gonadal hormone status | .340† | |
| Eugonadism (n = 48) | 1.5 (1.3-1.7) | |
| Hypogonadism (n = 5) | 0.7 (0.3-1.2) | |
| Compensated hypogonadism (n = 18) | 1.3 (1.0-1.6) | |
| Monthly priapism rate by use of hydroxyurea | <.001 | |
| No hydroxyurea (n = 60) | 1.2 (1.0-1.3) | |
| Hydroxyurea (n = 11) | 2.7 (2.2-3.3) | |
| Monthly rate of priapism in months 2 and 3 by whether priapism occurred in first month | .006 | |
| No priapism in first month (n = 26) | 0.7 (0.5-1.0) | |
| Priapism in first month (n = 45) | 1.3 (1.1-1.5) | |
| Characteristic . | Priapism rate (95% CI) . | P value∗ . |
|---|---|---|
| Retrospective and prospective priapism rates, events per year (n = 73) | <.001 | |
| Retrospective from history (n = 73) | 23.6 (22.5-24.8) | |
| Prospective from diary (n = 71) | 16.8 (14.9-18.8) | |
| Monthly priapism rate by experiencing major priapism in prospective period | <.001 | |
| No major priapism (n = 53) | 1.2 (1.0-1.3) | |
| At least one major priapism (n = 18) | 2.1 (1.8-2.5) | |
| Monthly priapism rate by gonadal hormone status | .340† | |
| Eugonadism (n = 48) | 1.5 (1.3-1.7) | |
| Hypogonadism (n = 5) | 0.7 (0.3-1.2) | |
| Compensated hypogonadism (n = 18) | 1.3 (1.0-1.6) | |
| Monthly priapism rate by use of hydroxyurea | <.001 | |
| No hydroxyurea (n = 60) | 1.2 (1.0-1.3) | |
| Hydroxyurea (n = 11) | 2.7 (2.2-3.3) | |
| Monthly rate of priapism in months 2 and 3 by whether priapism occurred in first month | .006 | |
| No priapism in first month (n = 26) | 0.7 (0.5-1.0) | |
| Priapism in first month (n = 45) | 1.3 (1.1-1.5) | |