| 1. | Distance of >50 kb from 5′ end of any gene |
| 2. | Distance of >300 kb from any cancer-related genes |
| 3. | Distance of >300 kb from any miRNA |
| 4. | Outside a gene transcription unit |
| 5. | Outside of ultraconserved regions |
| 6. | Outside of noncoding RNAs |
| 7. | Within ATAC-seq peak in activated state and proximity to ATAC-seq peaks (<50 kb) and active genes in resting state (<200 kb) |
| 1. | Distance of >50 kb from 5′ end of any gene |
| 2. | Distance of >300 kb from any cancer-related genes |
| 3. | Distance of >300 kb from any miRNA |
| 4. | Outside a gene transcription unit |
| 5. | Outside of ultraconserved regions |
| 6. | Outside of noncoding RNAs |
| 7. | Within ATAC-seq peak in activated state and proximity to ATAC-seq peaks (<50 kb) and active genes in resting state (<200 kb) |