Location of parmodulin activity determining regions on PAR1
| Parmodulin . | Parmodulin activity determining region . | Experimental evidence . | References . |
|---|---|---|---|
| JF5, ML159, ML160, ML161 | Region after C365 (including second half of TM7, H8, and C terminus) | PAR1/PAR4 chimera | 35 |
| JF5, ML161 | H8 | H8 deletion (replacement of S376-L386 by triple alanine mutation) | 11,35 |
| JF5 | H8 | H8 sequence comparison of JF5-sensitive and insensitive GPCRs | 11 |
| JF5, ML161 | ICL3 | PAR1/PAR4 chimera | 35 |
| Parmodulin . | Parmodulin activity determining region . | Experimental evidence . | References . |
|---|---|---|---|
| JF5, ML159, ML160, ML161 | Region after C365 (including second half of TM7, H8, and C terminus) | PAR1/PAR4 chimera | 35 |
| JF5, ML161 | H8 | H8 deletion (replacement of S376-L386 by triple alanine mutation) | 11,35 |
| JF5 | H8 | H8 sequence comparison of JF5-sensitive and insensitive GPCRs | 11 |
| JF5, ML161 | ICL3 | PAR1/PAR4 chimera | 35 |