Factor activity levels and INR assessed at the time of hemostasis
| . | Hemostasis: yes (mean ± SD) . | Hemostasis: no (mean ± SD) . | P-value . |
|---|---|---|---|
| 4F-PCC | |||
| Factor activity levels∗ | n = 45 | n = 5 | |
| FII | 90.2 ± 25.2 | 85.8 ± 24.2 | .72 |
| FVII | 65.7 ± 47.4 | 59.6 ± 13.9 | .52 |
| FIX | 77.2 ± 29.4 | 70.8 ± 24.1 | .6 |
| FX | 88.6 ± 27.7 | 83.4 ± 27.6 | .71 |
| Median INR† | 1.2 (n = 62) | 1.35 (n = 6) | .40 |
| Plasma | |||
| Factor activity levels∗ | n = 44 | n = 6 | |
| FII | 64.6 ± 30.3 | 45.2 ± 12.7 | .013 |
| FVII | 72.1 ± 56.0 | 44.5 ± 16.1 | .016 |
| FIX | 77.5 ± 30.6 | 57.5 ± 7.8 | .001 |
| FX | 56.3 ± 26.6 | 32.2 ± 7.9 | < .001 |
| Median INR† | 1.4 (n = 56) | 1.6 (n = 16) | .002 |
| . | Hemostasis: yes (mean ± SD) . | Hemostasis: no (mean ± SD) . | P-value . |
|---|---|---|---|
| 4F-PCC | |||
| Factor activity levels∗ | n = 45 | n = 5 | |
| FII | 90.2 ± 25.2 | 85.8 ± 24.2 | .72 |
| FVII | 65.7 ± 47.4 | 59.6 ± 13.9 | .52 |
| FIX | 77.2 ± 29.4 | 70.8 ± 24.1 | .6 |
| FX | 88.6 ± 27.7 | 83.4 ± 27.6 | .71 |
| Median INR† | 1.2 (n = 62) | 1.35 (n = 6) | .40 |
| Plasma | |||
| Factor activity levels∗ | n = 44 | n = 6 | |
| FII | 64.6 ± 30.3 | 45.2 ± 12.7 | .013 |
| FVII | 72.1 ± 56.0 | 44.5 ± 16.1 | .016 |
| FIX | 77.5 ± 30.6 | 57.5 ± 7.8 | .001 |
| FX | 56.3 ± 26.6 | 32.2 ± 7.9 | < .001 |
| Median INR† | 1.4 (n = 56) | 1.6 (n = 16) | .002 |
Effective hemostasis was observed in 78 of 87 (90%) patients receiving 4F-PCC and in 61 of 81 (75%) patients receiving plasma (P = .0142). The values reflect data available within ±3 hours of the time of hemostasis assessment.
SD, standard deviation.
Student t-test used for factor activity levels P-value.
Brown-mood test used for INR P-value.