Cox regression models including selected comorbidities for NRM, relapse, and OS
| Variable . | NRM . | Relapse . | OS . | |||
|---|---|---|---|---|---|---|
| HR (95% CI) . | P . | HR (95% CI) . | P . | HR (95% CI) . | P . | |
| Preexisting malignancy | 1.34 (0.88-2.02) | .16 | 1.39 (1.05-1.82) | .020 | 1.47 (1.16-1.87) | .002 |
| Composite cardiac | 1.52 (1.12-2.07) | .008 | 1.13 (0.89-1.43) | .307 | 1.39 (1.14-1.69) | .001 |
| Psychiatric | 1.70 (1.01-2.83) | .044 | 0.83 (0.53-1.30) | .412 | 1.09 (0.75-1.58) | .669 |
| Renal | 5.59 (2.72-11.50) | <.001 | 1.27 (0.53-3.08) | .594 | 2.75 (1.54-4.90) | <.001 |
| IBD | 3.66 (1.78-7.55) | <.001 | 1.86 (1.02-3.41) | .043 | 1.99 (1.19-3.35) | .009 |
| Age (by decade), y | 1.76 (1.46-2.13) | <.001 | 0.98 (0.89-1.08) | .634 | 1.22 (1.11-1.35) | <.001 |
| KPS | ||||||
| ≥90 | reference | |||||
| <90 | 0.87 (0.66-1.14) | .317 | 1.00 (0.83-1.22) | .966 | 0.90 (0.76-1.07) | .234 |
| Disease risk (disease risk stratification system) | ||||||
| Low | reference | |||||
| Intermediate-1 | 1.04 (0.73-1.47) | .846 | 1.34 (1.03-1.74) | .031 | 1.24 (0.99-1.56) | .067 |
| Intermediate-2/high | 1.10 (0.82-1.47) | .521 | 1.89 (1.54-2.32) | <.001 | 1.60 (1.33-1.92) | <.001 |
| Donor | ||||||
| Matched sibling donor | Reference | |||||
| Matched unrelated donor | 1.24 (0.93-1.65) | .135 | 0.83 (0.69-1.01) | .058 | 1.02 (0.86-1.21) | .850 |
| Female-to-male | 1.96 (1.44-2.67) | <.001 | 0.92 (0.72-1.18) | 0524 | 1.24 (1.01-1.53) | .041 |
| Cytomegalovirus | ||||||
| D−/R− | reference | |||||
| D−/R+ | 1.43 (0.98-2.08) | .065 | 0.99 (0.77-1.28) | .954 | 1.13 (0.90-1.42) | .293 |
| D+/R− | 1.03 (0.61-1.75) | .914 | 0.92 (0.65-1.31) | .657 | 0.94 (0.69-1.30) | .718 |
| D+/R+ | 1.12 (0.78-1.60) | .528 | 0.90 (0.71-1.13) | .370 | 0.95 (0.77-1.18) | .666 |
| Variable . | NRM . | Relapse . | OS . | |||
|---|---|---|---|---|---|---|
| HR (95% CI) . | P . | HR (95% CI) . | P . | HR (95% CI) . | P . | |
| Preexisting malignancy | 1.34 (0.88-2.02) | .16 | 1.39 (1.05-1.82) | .020 | 1.47 (1.16-1.87) | .002 |
| Composite cardiac | 1.52 (1.12-2.07) | .008 | 1.13 (0.89-1.43) | .307 | 1.39 (1.14-1.69) | .001 |
| Psychiatric | 1.70 (1.01-2.83) | .044 | 0.83 (0.53-1.30) | .412 | 1.09 (0.75-1.58) | .669 |
| Renal | 5.59 (2.72-11.50) | <.001 | 1.27 (0.53-3.08) | .594 | 2.75 (1.54-4.90) | <.001 |
| IBD | 3.66 (1.78-7.55) | <.001 | 1.86 (1.02-3.41) | .043 | 1.99 (1.19-3.35) | .009 |
| Age (by decade), y | 1.76 (1.46-2.13) | <.001 | 0.98 (0.89-1.08) | .634 | 1.22 (1.11-1.35) | <.001 |
| KPS | ||||||
| ≥90 | reference | |||||
| <90 | 0.87 (0.66-1.14) | .317 | 1.00 (0.83-1.22) | .966 | 0.90 (0.76-1.07) | .234 |
| Disease risk (disease risk stratification system) | ||||||
| Low | reference | |||||
| Intermediate-1 | 1.04 (0.73-1.47) | .846 | 1.34 (1.03-1.74) | .031 | 1.24 (0.99-1.56) | .067 |
| Intermediate-2/high | 1.10 (0.82-1.47) | .521 | 1.89 (1.54-2.32) | <.001 | 1.60 (1.33-1.92) | <.001 |
| Donor | ||||||
| Matched sibling donor | Reference | |||||
| Matched unrelated donor | 1.24 (0.93-1.65) | .135 | 0.83 (0.69-1.01) | .058 | 1.02 (0.86-1.21) | .850 |
| Female-to-male | 1.96 (1.44-2.67) | <.001 | 0.92 (0.72-1.18) | 0524 | 1.24 (1.01-1.53) | .041 |
| Cytomegalovirus | ||||||
| D−/R− | reference | |||||
| D−/R+ | 1.43 (0.98-2.08) | .065 | 0.99 (0.77-1.28) | .954 | 1.13 (0.90-1.42) | .293 |
| D+/R− | 1.03 (0.61-1.75) | .914 | 0.92 (0.65-1.31) | .657 | 0.94 (0.69-1.30) | .718 |
| D+/R+ | 1.12 (0.78-1.60) | .528 | 0.90 (0.71-1.13) | .370 | 0.95 (0.77-1.18) | .666 |