HRs of NRM associated with individual comorbidities in patients receiving low-TCI regimens
| Comorbidity . | N (%) . | Adjusted∗ HR (95% CI) . | P . |
|---|---|---|---|
| Rheumatologic | 40 (2) | 0.70 (0.26-1.90) | .489 |
| Moderate pulmonary | 275 (17) | 0.99 (0.70-1.41) | .954 |
| Active infection | 164 (10) | 1.06 (0.69-1.63) | .785 |
| Arrythmia | 73 (4) | 1.15 (0.65-2.02) | .636 |
| Diabetes mellitus | 112 (7) | 1.17 (0.73-1.88) | .509 |
| Obesity | 58 (3) | 1.25 (0.66-2.36) | .494 |
| Cerebrovascular | 38 (2) | 1.28 (0.60-2.74) | .529 |
| Prior malignancy | 155 (9) | 1.29 (0.85-1.94) | .230 |
| Cardiac disease† | 182 (11) | 1.32 (0.91-1.90) | .143 |
| Mild/moderate hepatic | 90 (5) | 1.34 (0.79-2.28) | .273 |
| Severe hepatic | 26 (2) | 1.38 (0.51-3.74) | .530 |
| Severe pulmonary | 183 (11) | 1.43 (0.99-2.07) | .058 |
| Composite cardiac‡ | 263 (16) | 1.54 (1.13-2.09) | .006 |
| Psychiatric | 75 (5) | 1.69 (1.02-2.82) | .043 |
| Valvular disease | 38 (2) | 2.44 (1.37-4.35) | .002 |
| Peptic ulcer | 14 (1) | 3.01 (1.11-8.15) | .031 |
| IBD | 26 (2) | 3.88 (1.90-7.96) | <.001 |
| Renal | 20 (1) | 5.29 (2.58-10.85) | <.001 |
| HCT-CI§ | |||
| 1-2 points | 434 (26) | 1.17 (0.83-1.64) | .363 |
| ≥3 points | 516 (31) | 1.70 (1.25-2.30) | .001 |
| Additional covariates‖ | |||
| KPS <90 | 523 (29) | 1.13 (0.86-1.49) | .365 |
| Age (by decade) | 1.71 (1.42-2.07) | <.001 |
| Comorbidity . | N (%) . | Adjusted∗ HR (95% CI) . | P . |
|---|---|---|---|
| Rheumatologic | 40 (2) | 0.70 (0.26-1.90) | .489 |
| Moderate pulmonary | 275 (17) | 0.99 (0.70-1.41) | .954 |
| Active infection | 164 (10) | 1.06 (0.69-1.63) | .785 |
| Arrythmia | 73 (4) | 1.15 (0.65-2.02) | .636 |
| Diabetes mellitus | 112 (7) | 1.17 (0.73-1.88) | .509 |
| Obesity | 58 (3) | 1.25 (0.66-2.36) | .494 |
| Cerebrovascular | 38 (2) | 1.28 (0.60-2.74) | .529 |
| Prior malignancy | 155 (9) | 1.29 (0.85-1.94) | .230 |
| Cardiac disease† | 182 (11) | 1.32 (0.91-1.90) | .143 |
| Mild/moderate hepatic | 90 (5) | 1.34 (0.79-2.28) | .273 |
| Severe hepatic | 26 (2) | 1.38 (0.51-3.74) | .530 |
| Severe pulmonary | 183 (11) | 1.43 (0.99-2.07) | .058 |
| Composite cardiac‡ | 263 (16) | 1.54 (1.13-2.09) | .006 |
| Psychiatric | 75 (5) | 1.69 (1.02-2.82) | .043 |
| Valvular disease | 38 (2) | 2.44 (1.37-4.35) | .002 |
| Peptic ulcer | 14 (1) | 3.01 (1.11-8.15) | .031 |
| IBD | 26 (2) | 3.88 (1.90-7.96) | <.001 |
| Renal | 20 (1) | 5.29 (2.58-10.85) | <.001 |
| HCT-CI§ | |||
| 1-2 points | 434 (26) | 1.17 (0.83-1.64) | .363 |
| ≥3 points | 516 (31) | 1.70 (1.25-2.30) | .001 |
| Additional covariates‖ | |||
| KPS <90 | 523 (29) | 1.13 (0.86-1.49) | .365 |
| Age (by decade) | 1.71 (1.42-2.07) | <.001 |
Adjusted for age, KPS, disease risk (disease risk stratification system), donor type, sex mismatch, and donor/recipient cytomegalovirus serostatus.
HCT-CI definition.
HCT-CI definition plus valvular disease and arrhythmia.
The HCT-CI was not included in the model; HRs adjusted using the same covariates as in ∗ are shown here for comparison.
Studied as the primary effect in models with the same adjustment covariates.