Multivariable Cox regressions
| . | EFS . | OS . | Relapse . | TRM∗ . | cGvHD∗ . | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| HR (95% CI) . | P value . | HR (95% CI) . | P value . | HR (95% CI) . | P value . | HR (95% CI) . | P value . | HR (95% CI) . | P value . | |
| T-replete vs comparator | 0.57 (0.35-0.91) | .019 | 0.65 (0.39-1.07) | .088 | 0.46 (0.26-0.81) | .008 | 2.04 (1.03-4.06) | .042 | 0.28 (0.11-0.70) | .007 |
| RIC vs MAC | 1.52 (0.93-2.48) | .096 | 1.41 (0.82-2.41) | .211 | 1.40 (0.80-2.47) | .241 | - | - | - | - |
| MRD positive vs negative | 3.97 (2.74-5.75) | <.001 | 4.46 (2.98-6.68) | <.001 | 4.09 (2.68-6.25) | <.001 | - | - | - | - |
| Age at transplant (per 5 y) | 0.99 (0.83-1.18) | .902 | 0.93 (0.77-1.31) | .483 | 0.90 (0.74-1.10) | .313 | - | - | 1.35 (1.01-1.81) | .039 |
| MDS vs AML | 0.79 (0.45-1.41) | .428 | 0.47 (0.23-0.97) | .040 | 0.96 (0.51-1.83) | .908 | - | - | - | - |
| Previous BMT vs no previous BMT | 1.36 (0.76-2.40) | .298 | 1.36 (0.73-2.52) | .329 | 1.10 (0.55-2.17) | .790 | - | - | - | - |
| Fully matched vs mismatched cord | 0.99 (0.66-1.50) | .976 | 0.86 (0.55-1.33) | .488 | 1.34 (0.81-2.22) | .251 | - | - | - | - |
| . | EFS . | OS . | Relapse . | TRM∗ . | cGvHD∗ . | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| HR (95% CI) . | P value . | HR (95% CI) . | P value . | HR (95% CI) . | P value . | HR (95% CI) . | P value . | HR (95% CI) . | P value . | |
| T-replete vs comparator | 0.57 (0.35-0.91) | .019 | 0.65 (0.39-1.07) | .088 | 0.46 (0.26-0.81) | .008 | 2.04 (1.03-4.06) | .042 | 0.28 (0.11-0.70) | .007 |
| RIC vs MAC | 1.52 (0.93-2.48) | .096 | 1.41 (0.82-2.41) | .211 | 1.40 (0.80-2.47) | .241 | - | - | - | - |
| MRD positive vs negative | 3.97 (2.74-5.75) | <.001 | 4.46 (2.98-6.68) | <.001 | 4.09 (2.68-6.25) | <.001 | - | - | - | - |
| Age at transplant (per 5 y) | 0.99 (0.83-1.18) | .902 | 0.93 (0.77-1.31) | .483 | 0.90 (0.74-1.10) | .313 | - | - | 1.35 (1.01-1.81) | .039 |
| MDS vs AML | 0.79 (0.45-1.41) | .428 | 0.47 (0.23-0.97) | .040 | 0.96 (0.51-1.83) | .908 | - | - | - | - |
| Previous BMT vs no previous BMT | 1.36 (0.76-2.40) | .298 | 1.36 (0.73-2.52) | .329 | 1.10 (0.55-2.17) | .790 | - | - | - | - |
| Fully matched vs mismatched cord | 0.99 (0.66-1.50) | .976 | 0.86 (0.55-1.33) | .488 | 1.34 (0.81-2.22) | .251 | - | - | - | - |
BMT, bone marrow transplant; cGvHD, chronic graft versus host disease; MAC, myeloablative conditioning; RIC, reduced-intensity conditioning.
Models chosen with forward selection.