Patient and transplant characteristics
| . | T-replete cord (n = 112) . | Comparator (n = 255) . | P value∗ . |
|---|---|---|---|
| Age, y | 6.5 (2.5-11) | 8.9 (3.9-13.2) | .005 |
| Diagnosis | |||
| AML | 102 (91.1) | 232 (91) | .978 |
| MDS | 10 (9) | 23 (9) | |
| Conditioning | |||
| MAC | 92 (82.1) | 233 (91.4) | |
| RIC | 20 (17.9) | 22 (8.6) | .011 |
| HLA-match | |||
| Fully matched (8/8 cord or 10/10 MUD or sib) | 32 (28.6) | 208 (81.6) | |
| Mismatched (≤7/8 or ≤9/10) | 80 (71.4) | 47 (18.4) | <.001 |
| MRD | |||
| Positive | 57 (51.4) | 60 (26.1) | |
| Negative | 54 (48.7) | 170 (73.9) | |
| No marker | 0 | 25 | <.001† |
| Clinical disease status | |||
| Primary refractory | 29 (25.9) | 13 (5.1) | |
| Relapsed refractory | 23 (20.5) | 9 (3.5) | |
| CR2 | 22 (19.6) | 84 (32.9) | |
| High risk CR1 | 38 (33.9) | 118 (46.3) | |
| Other (untreated MDS) | 0 | 31 (12.2) | <.001† |
| Previous BMT | 24 (21.4) | 13 (5.1) | <.001 |
| . | T-replete cord (n = 112) . | Comparator (n = 255) . | P value∗ . |
|---|---|---|---|
| Age, y | 6.5 (2.5-11) | 8.9 (3.9-13.2) | .005 |
| Diagnosis | |||
| AML | 102 (91.1) | 232 (91) | .978 |
| MDS | 10 (9) | 23 (9) | |
| Conditioning | |||
| MAC | 92 (82.1) | 233 (91.4) | |
| RIC | 20 (17.9) | 22 (8.6) | .011 |
| HLA-match | |||
| Fully matched (8/8 cord or 10/10 MUD or sib) | 32 (28.6) | 208 (81.6) | |
| Mismatched (≤7/8 or ≤9/10) | 80 (71.4) | 47 (18.4) | <.001 |
| MRD | |||
| Positive | 57 (51.4) | 60 (26.1) | |
| Negative | 54 (48.7) | 170 (73.9) | |
| No marker | 0 | 25 | <.001† |
| Clinical disease status | |||
| Primary refractory | 29 (25.9) | 13 (5.1) | |
| Relapsed refractory | 23 (20.5) | 9 (3.5) | |
| CR2 | 22 (19.6) | 84 (32.9) | |
| High risk CR1 | 38 (33.9) | 118 (46.3) | |
| Other (untreated MDS) | 0 | 31 (12.2) | <.001† |
| Previous BMT | 24 (21.4) | 13 (5.1) | <.001 |
Data are median (interquartile range) or number (percentage).
BMT, bone marrow transplant; CR, complete remission; MAC, myeloablative conditioning; RIC, reduced-intensity conditioning; sib, sibling.
Wilcoxon rank-sum test (continuous), Pearson chi-square test or Fisher exact test (discrete variables).
Category “Other” of clinical disease status and category “No marker” of MRD were not included in the calculation of P value.