Numbers, events, person-years, 10-year risks, and overall (0-10 years) adjusted HRs of mortality owing to conditions of the circulatory system, respiratory system, and neoplasms, comparing patients with a first-time diagnosis of CVT with matched individuals from the GP
| . | N . | Events, N . | Person-years, n . | Risk, % . | Adjusted HR∗ . | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| CVT . | GP . | CVT . | GP . | CVT . | GP . | CVT . | GP . | Difference . | ||
| Mortality, circulatory system | ||||||||||
| All | 612 | 63 349 | 26 | 590 | 3 816 | 423 016 | 5.4 | 1.5 | 4.0 (1.8-6.1) | 8.69 (5.73-13.16) |
| Women, aged 18-54 y | 333 | 34 136 | 5 | 19 | 2 201 | 235 222 | 1.6 | 0.1 | 1.5 (0.1-2.8) | 26.01 (7.58-89.24) |
| Women, aged ≥55 y | 77 | 8 619 | 9 | 348 | 398 | 52 552 | 17.9 | 6.6 | 11.3 (−0.3 to 22.8) | 7.01 (3.50-14.06) |
| Men, aged 18-54 y | 123 | 12 520 | 5 | 20 | 849 | 89 449 | 5.3 | 0.2 | 5.0 (0.3-9.7) | 22.37 (7.02-71.30) |
| Men, aged ≥55 y | 79 | 8 074 | 7 | 203 | 368 | 45 792 | 10.5 | 4.8 | 5.8 (−2.0 to 13.5) | 5.17 (2.34-11.41) |
| Mortality, respiratory system | ||||||||||
| All | 612 | 63 349 | 7 | 523 | 3 816 | 423 016 | 1.6 | 1.3 | 0.3 (−0.9 to 1.5) | 1.74 (0.81-3.72) |
| Women, aged 18-54 y | 333 | 34 136 | 0 | 29 | 2 201 | 235 222 | 0.0 | 0.1 | −0.1 (−0.2 to −0.1) | — |
| Women, aged ≥55 y | 77 | 8 619 | <5 | 282 | 398 | 52 552 | 5.3 | 5.4 | −0.1 (−6.1 to 6.0) | 1.72 (0.54-5.46) |
| Men, aged 18-54 y | 123 | 12 520 | 0 | 10 | 849 | 89 449 | 0.0 | 0.1 | −0.1 (−0.2 to −0.0) | — |
| Men, aged ≥55 y | 79 | 8 074 | <5 | 202 | 368 | 45 792 | 9.8 | 5.0 | 4.8 (−5.6 to 15.2) | 2.64 (0.94-7.37) |
| Mortality, neoplasms | ||||||||||
| All | 612 | 63 349 | 13 | 638 | 3 816 | 423 016 | 2.5 | 1.5 | 1.0 (−0.4 to 2.4) | 1.98 (1.12-3.49) |
| Women, aged 18-54 y | 333 | 34 136 | <5 | 55 | 2 201 | 235 222 | 1.4 | 0.3 | 1.2 (−0.3 to 2.6) | 3.87 (1.21-12.43) |
| Women, aged ≥55 y | 77 | 8 619 | <5 | 292 | 398 | 52 552 | 6.1 | 5.4 | 0.7 (−5.3 to 6.6) | 1.78 (0.65-4.86) |
| Men, aged 18-54 y | 123 | 12 520 | <5 | 28 | 849 | 89 449 | 2.0 | 0.3 | 1.7 (−1.1 to 4.5) | 6.56 (1.41-30.58) |
| Men, aged ≥55 y | 79 | 8 074 | <5 | 263 | 368 | 45 792 | 4.9 | 5.7 | −0.8 (−6.4 to 4.8) | 0.97 (0.30-3.14) |
| . | N . | Events, N . | Person-years, n . | Risk, % . | Adjusted HR∗ . | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| CVT . | GP . | CVT . | GP . | CVT . | GP . | CVT . | GP . | Difference . | ||
| Mortality, circulatory system | ||||||||||
| All | 612 | 63 349 | 26 | 590 | 3 816 | 423 016 | 5.4 | 1.5 | 4.0 (1.8-6.1) | 8.69 (5.73-13.16) |
| Women, aged 18-54 y | 333 | 34 136 | 5 | 19 | 2 201 | 235 222 | 1.6 | 0.1 | 1.5 (0.1-2.8) | 26.01 (7.58-89.24) |
| Women, aged ≥55 y | 77 | 8 619 | 9 | 348 | 398 | 52 552 | 17.9 | 6.6 | 11.3 (−0.3 to 22.8) | 7.01 (3.50-14.06) |
| Men, aged 18-54 y | 123 | 12 520 | 5 | 20 | 849 | 89 449 | 5.3 | 0.2 | 5.0 (0.3-9.7) | 22.37 (7.02-71.30) |
| Men, aged ≥55 y | 79 | 8 074 | 7 | 203 | 368 | 45 792 | 10.5 | 4.8 | 5.8 (−2.0 to 13.5) | 5.17 (2.34-11.41) |
| Mortality, respiratory system | ||||||||||
| All | 612 | 63 349 | 7 | 523 | 3 816 | 423 016 | 1.6 | 1.3 | 0.3 (−0.9 to 1.5) | 1.74 (0.81-3.72) |
| Women, aged 18-54 y | 333 | 34 136 | 0 | 29 | 2 201 | 235 222 | 0.0 | 0.1 | −0.1 (−0.2 to −0.1) | — |
| Women, aged ≥55 y | 77 | 8 619 | <5 | 282 | 398 | 52 552 | 5.3 | 5.4 | −0.1 (−6.1 to 6.0) | 1.72 (0.54-5.46) |
| Men, aged 18-54 y | 123 | 12 520 | 0 | 10 | 849 | 89 449 | 0.0 | 0.1 | −0.1 (−0.2 to −0.0) | — |
| Men, aged ≥55 y | 79 | 8 074 | <5 | 202 | 368 | 45 792 | 9.8 | 5.0 | 4.8 (−5.6 to 15.2) | 2.64 (0.94-7.37) |
| Mortality, neoplasms | ||||||||||
| All | 612 | 63 349 | 13 | 638 | 3 816 | 423 016 | 2.5 | 1.5 | 1.0 (−0.4 to 2.4) | 1.98 (1.12-3.49) |
| Women, aged 18-54 y | 333 | 34 136 | <5 | 55 | 2 201 | 235 222 | 1.4 | 0.3 | 1.2 (−0.3 to 2.6) | 3.87 (1.21-12.43) |
| Women, aged ≥55 y | 77 | 8 619 | <5 | 292 | 398 | 52 552 | 6.1 | 5.4 | 0.7 (−5.3 to 6.6) | 1.78 (0.65-4.86) |
| Men, aged 18-54 y | 123 | 12 520 | <5 | 28 | 849 | 89 449 | 2.0 | 0.3 | 1.7 (−1.1 to 4.5) | 6.56 (1.41-30.58) |
| Men, aged ≥55 y | 79 | 8 074 | <5 | 263 | 368 | 45 792 | 4.9 | 5.7 | −0.8 (−6.4 to 4.8) | 0.97 (0.30-3.14) |
Controlled for matching factors (age, sex, and calendar period) by design and adjusted for cancer, recent infection, fracture/trauma, surgery, or pregnancy, previous VTE, myocardial infarction, ischemic and hemorrhagic stroke, major bleeding, other ischemic heart disease, atrial fibrillation, hypertension, diabetes, obesity, peripheral artery disease, chronic liver disease, and chronic pulmonary disease.