Numbers, events, person-years, 10-year risks, and overall (0-10 years) adjusted HRs of CVT recurrence, VTE at other sites, myocardial infarction, ischemic stroke, and all-cause mortality, comparing patients with a first-time diagnosis of CVT and matched individuals from the GP
| . | N . | Events, N . | Person-years, n . | Risk, % . | Adjusted HR (95% CI)∗ . | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| CVT . | GP . | CVT . | GP . | CVT . | GP . | CVT . | GP . | Difference (95% CI) . | ||
| CVT recurrence | ||||||||||
| All | 653 | 65 300 | 37 | — | 3 745 | — | 6.3 | — | — | — |
| Women, aged 18-54 y | 343 | 34 285 | 26 | — | 2 070 | — | 8.3 | — | — | — |
| Women, aged ≥55 y | 95 | 9 515 | 0 | — | 480 | — | - | — | — | — |
| Men, aged 18-54 y | 128 | 12 682 | <10 | — | 819 | — | 8.0 | — | — | — |
| Men, aged ≥55 y | 87 | 8 818 | <5 | — | 375 | — | 2.4 | — | — | — |
| VTE | ||||||||||
| All | 653 | 65 300 | 12 | 346 | 3 934 | 434 537 | 2.4 | 0.8 | 1.6 (0.2-3.0) | 3.95 (2.20-7.11) |
| Women, aged 18-54 y | 343 | 34 285 | 6 | 94 | 2 212 | 235 970 | 2.2 | 0.4 | 1.8 (0.0-3.6) | 6.55 (2.79-15.35) |
| Women, aged ≥55 y | 95 | 9 515 | <5 | 102 | 476 | 57 791 | 2.2 | 1.6 | 0.6 (−2.5 to 3.7) | 2.65 (0.64-10.97) |
| Men, aged 18-54 y | 128 | 12 682 | <5 | 40 | 857 | 90 556 | 3.3 | 0.5 | 2.9 (−0.9 to 6.6) | 7.34 (2.14-25.23) |
| Men, aged ≥55 y | 87 | 8 818 | <5 | 110 | 389 | 50 219 | 1.3 | 2.2 | −0.9 (−3.4 to 1.5) | 1.13 (0.15-8.31) |
| Myocardial infarction | ||||||||||
| All | 653 | 65 300 | 5 | 615 | 3 974 | 433 444 | 0.9 | 1.4 | −0.5 (−1.3, 0.3) | 0.93 (0.38-2.26) |
| Women, aged 18-54 y | 343 | 34 285 | <5 | 69 | 2 245 | 236 093 | 0.4 | 0.3 | 0.0 (−0.7 to 0.8) | 0.50 (0.04-6.12) |
| Women, aged ≥55 y | 95 | 9 515 | <5 | 157 | 480 | 57 565 | 1.1 | 2.4 | −1.2 (−3.5 to 1.0) | 0.99 (0.14-7.12) |
| Men, aged 18-54 y | 128 | 12 682 | <5 | 111 | 865 | 90 242 | 0.0 | 1.3 | −1.3 (−1.5 to −1.0) | — |
| Men, aged ≥55 y | 87 | 8 818 | <5 | 278 | 384 | 49 545 | 3.9 | 5.1 | −1.2 (−5.6 to 3.2) | 1.46 (0.46-4.63) |
| Ischemic stroke | ||||||||||
| All | 653 | 65 300 | 29 | 519 | 3 852 | 434 040 | 5.4 | 1.2 | 4.2 (2.2-6.2) | 7.40 (5.02-10.91) |
| Women, aged 18-54 y | 343 | 34 285 | 5 | 57 | 2 212 | 236 163 | 1.5 | 0.3 | 1.2 (−0.1 to 2.6) | 6.47 (2.27-18.41) |
| Women, aged ≥55 y | 95 | 9 515 | 9 | 198 | 445 | 57 505 | 12.8 | 3.1 | 9.7 (1.6-17.9) | 6.63 (3.32-13.23) |
| Men, aged 18-54 y | 128 | 12 682 | 9 | 54 | 817 | 90 505 | 8.8 | 0.6 | 8.1 (2.5-13.8) | 20.20 (9.51-42.91) |
| Men, aged ≥55 y | 87 | 8 818 | 6 | 210 | 379 | 49 866 | 7.0 | 3.9 | 3.1 (−2.3 to 8.5) | 3.86 (1.66-8.99) |
| Major bleeding | ||||||||||
| All | 653 | 65 300 | 27 | 850 | 3 900 | 432 952 | 5.3 | 1.9 | 3.4 (1.3-5.5) | 3.69 (2.49-5.47) |
| Women, aged 18-54 y | 343 | 34 285 | <5 | 158 | 2 230 | 235 645 | 1.8 | 0.7 | 1.1 (−0.7 to 2.8) | 1.77 (0.63-4.99) |
| Women, aged ≥55 y | 95 | 9 515 | <10 | 289 | 464 | 57 323 | 11.1 | 4.6 | 6.5 (−1.0 to 14.1) | 3.97 (1.93-8.18) |
| Men, aged 18-54 y | 128 | 12 682 | 10 | 101 | 819 | 90 269 | 9.8 | 1.1 | 8.6 (2.6-14.7) | 9.75 (4.87-19.51) |
| Men, aged ≥55 y | 87 | 8 818 | 5 | 302 | 387 | 49 715 | 6.1 | 5.7 | 0.3 (−4.9 to 5.5) | 2.29 (0.92-5.70) |
| All-cause mortality | ||||||||||
| All | 653 | 65 300 | 82 | 3 221 | 3 985 | 435 586 | 15.8 | 7.5 | 8.2 (4.9-11.6) | 3.22 (2.57-4.04) |
| Women, aged 18-54 y | 343 | 34 285 | 17 | 182 | 2 246 | 236 335 | 5.3 | 0.8 | 4.5 (2.0-7.0) | 5.99 (3.45-10.38) |
| Women, aged ≥55 y | 95 | 9 515 | 31 | 1 671 | 480 | 58 062 | 43.1 | 26.7 | 16.4 (3.7-29.1) | 2.82 (1.96-4.05) |
| Men, aged 18-54 y | 128 | 12 682 | 10 | 172 | 865 | 90 696 | 9.7 | 2.1 | 7.6 (1.7-13.5) | 3.96 (1.96-7.99) |
| Men, aged ≥55 y | 87 | 8 818 | 24 | 1 196 | 394 | 50 494 | 39.1 | 23.7 | 15.3 (1.4-29.3) | 2.50 (1.65-3.79) |
| . | N . | Events, N . | Person-years, n . | Risk, % . | Adjusted HR (95% CI)∗ . | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| CVT . | GP . | CVT . | GP . | CVT . | GP . | CVT . | GP . | Difference (95% CI) . | ||
| CVT recurrence | ||||||||||
| All | 653 | 65 300 | 37 | — | 3 745 | — | 6.3 | — | — | — |
| Women, aged 18-54 y | 343 | 34 285 | 26 | — | 2 070 | — | 8.3 | — | — | — |
| Women, aged ≥55 y | 95 | 9 515 | 0 | — | 480 | — | - | — | — | — |
| Men, aged 18-54 y | 128 | 12 682 | <10 | — | 819 | — | 8.0 | — | — | — |
| Men, aged ≥55 y | 87 | 8 818 | <5 | — | 375 | — | 2.4 | — | — | — |
| VTE | ||||||||||
| All | 653 | 65 300 | 12 | 346 | 3 934 | 434 537 | 2.4 | 0.8 | 1.6 (0.2-3.0) | 3.95 (2.20-7.11) |
| Women, aged 18-54 y | 343 | 34 285 | 6 | 94 | 2 212 | 235 970 | 2.2 | 0.4 | 1.8 (0.0-3.6) | 6.55 (2.79-15.35) |
| Women, aged ≥55 y | 95 | 9 515 | <5 | 102 | 476 | 57 791 | 2.2 | 1.6 | 0.6 (−2.5 to 3.7) | 2.65 (0.64-10.97) |
| Men, aged 18-54 y | 128 | 12 682 | <5 | 40 | 857 | 90 556 | 3.3 | 0.5 | 2.9 (−0.9 to 6.6) | 7.34 (2.14-25.23) |
| Men, aged ≥55 y | 87 | 8 818 | <5 | 110 | 389 | 50 219 | 1.3 | 2.2 | −0.9 (−3.4 to 1.5) | 1.13 (0.15-8.31) |
| Myocardial infarction | ||||||||||
| All | 653 | 65 300 | 5 | 615 | 3 974 | 433 444 | 0.9 | 1.4 | −0.5 (−1.3, 0.3) | 0.93 (0.38-2.26) |
| Women, aged 18-54 y | 343 | 34 285 | <5 | 69 | 2 245 | 236 093 | 0.4 | 0.3 | 0.0 (−0.7 to 0.8) | 0.50 (0.04-6.12) |
| Women, aged ≥55 y | 95 | 9 515 | <5 | 157 | 480 | 57 565 | 1.1 | 2.4 | −1.2 (−3.5 to 1.0) | 0.99 (0.14-7.12) |
| Men, aged 18-54 y | 128 | 12 682 | <5 | 111 | 865 | 90 242 | 0.0 | 1.3 | −1.3 (−1.5 to −1.0) | — |
| Men, aged ≥55 y | 87 | 8 818 | <5 | 278 | 384 | 49 545 | 3.9 | 5.1 | −1.2 (−5.6 to 3.2) | 1.46 (0.46-4.63) |
| Ischemic stroke | ||||||||||
| All | 653 | 65 300 | 29 | 519 | 3 852 | 434 040 | 5.4 | 1.2 | 4.2 (2.2-6.2) | 7.40 (5.02-10.91) |
| Women, aged 18-54 y | 343 | 34 285 | 5 | 57 | 2 212 | 236 163 | 1.5 | 0.3 | 1.2 (−0.1 to 2.6) | 6.47 (2.27-18.41) |
| Women, aged ≥55 y | 95 | 9 515 | 9 | 198 | 445 | 57 505 | 12.8 | 3.1 | 9.7 (1.6-17.9) | 6.63 (3.32-13.23) |
| Men, aged 18-54 y | 128 | 12 682 | 9 | 54 | 817 | 90 505 | 8.8 | 0.6 | 8.1 (2.5-13.8) | 20.20 (9.51-42.91) |
| Men, aged ≥55 y | 87 | 8 818 | 6 | 210 | 379 | 49 866 | 7.0 | 3.9 | 3.1 (−2.3 to 8.5) | 3.86 (1.66-8.99) |
| Major bleeding | ||||||||||
| All | 653 | 65 300 | 27 | 850 | 3 900 | 432 952 | 5.3 | 1.9 | 3.4 (1.3-5.5) | 3.69 (2.49-5.47) |
| Women, aged 18-54 y | 343 | 34 285 | <5 | 158 | 2 230 | 235 645 | 1.8 | 0.7 | 1.1 (−0.7 to 2.8) | 1.77 (0.63-4.99) |
| Women, aged ≥55 y | 95 | 9 515 | <10 | 289 | 464 | 57 323 | 11.1 | 4.6 | 6.5 (−1.0 to 14.1) | 3.97 (1.93-8.18) |
| Men, aged 18-54 y | 128 | 12 682 | 10 | 101 | 819 | 90 269 | 9.8 | 1.1 | 8.6 (2.6-14.7) | 9.75 (4.87-19.51) |
| Men, aged ≥55 y | 87 | 8 818 | 5 | 302 | 387 | 49 715 | 6.1 | 5.7 | 0.3 (−4.9 to 5.5) | 2.29 (0.92-5.70) |
| All-cause mortality | ||||||||||
| All | 653 | 65 300 | 82 | 3 221 | 3 985 | 435 586 | 15.8 | 7.5 | 8.2 (4.9-11.6) | 3.22 (2.57-4.04) |
| Women, aged 18-54 y | 343 | 34 285 | 17 | 182 | 2 246 | 236 335 | 5.3 | 0.8 | 4.5 (2.0-7.0) | 5.99 (3.45-10.38) |
| Women, aged ≥55 y | 95 | 9 515 | 31 | 1 671 | 480 | 58 062 | 43.1 | 26.7 | 16.4 (3.7-29.1) | 2.82 (1.96-4.05) |
| Men, aged 18-54 y | 128 | 12 682 | 10 | 172 | 865 | 90 696 | 9.7 | 2.1 | 7.6 (1.7-13.5) | 3.96 (1.96-7.99) |
| Men, aged ≥55 y | 87 | 8 818 | 24 | 1 196 | 394 | 50 494 | 39.1 | 23.7 | 15.3 (1.4-29.3) | 2.50 (1.65-3.79) |
Controlled for matching factors (age, sex, and calendar period) by design and adjusted for cancer, recent infection, fracture/trauma, surgery, or pregnancy, previous VTE, myocardial infarction, ischemic and hemorrhagic stroke, major bleeding, other ischemic heart disease, atrial fibrillation, hypertension, diabetes, obesity, peripheral artery disease, chronic liver disease, and chronic pulmonary disease.