Summary of CAR-T kinetic parameters based on best overall response, as measured in the peripheral blood using qPCR
| Parameter . | Statistics . | CR (N = 23) . | PR (N = 8) . | SD (N = 2) . | PD (N = 14) . | Total (N = 47) . |
|---|---|---|---|---|---|---|
| Cmax (copies per μg DNA) | Geo-mean | 6 222.7 | 5 645.9 | 2 067.7 | 1 956.3 | 4 205.4 |
| Geo-CV% | 197.1 | 104.9 | 305.2 | 668.4 | 290.9 | |
| Tmax (d) | Median | 12.2 | 9.9 | 13.4 | 12.0 | 11.9 |
| Min-max | 7-58 | 7-14 | 10-17 | 7-28 | 7-58 | |
| AUC 0-28 d (day × copies per μg DNA) | Geo-mean | 55 968.7 | 53 883.6 | 24 922.9 | 13 284.7 | 35 750.8 |
| Geo-CV% | 218.2 | 140.2 | 130.8 | 1 043.8 | 377.0 | |
| AUC 0-84 d (day × copies per μg DNA) | Geo-mean | 87 617.6 | 87 081.8 | 4 163.9 | 43 630.5 | |
| Geo-CV% | 248.0 | 227.6 | 260.8 | 577.2 | ||
| Tlast (d) | Median | 108.2 | 41.9 | 39.1 | 19.8 | 50.0 |
| Min-max | 16-734 | 14-168 | 28-50 | 7-55 | 7-734 |
| Parameter . | Statistics . | CR (N = 23) . | PR (N = 8) . | SD (N = 2) . | PD (N = 14) . | Total (N = 47) . |
|---|---|---|---|---|---|---|
| Cmax (copies per μg DNA) | Geo-mean | 6 222.7 | 5 645.9 | 2 067.7 | 1 956.3 | 4 205.4 |
| Geo-CV% | 197.1 | 104.9 | 305.2 | 668.4 | 290.9 | |
| Tmax (d) | Median | 12.2 | 9.9 | 13.4 | 12.0 | 11.9 |
| Min-max | 7-58 | 7-14 | 10-17 | 7-28 | 7-58 | |
| AUC 0-28 d (day × copies per μg DNA) | Geo-mean | 55 968.7 | 53 883.6 | 24 922.9 | 13 284.7 | 35 750.8 |
| Geo-CV% | 218.2 | 140.2 | 130.8 | 1 043.8 | 377.0 | |
| AUC 0-84 d (day × copies per μg DNA) | Geo-mean | 87 617.6 | 87 081.8 | 4 163.9 | 43 630.5 | |
| Geo-CV% | 248.0 | 227.6 | 260.8 | 577.2 | ||
| Tlast (d) | Median | 108.2 | 41.9 | 39.1 | 19.8 | 50.0 |
| Min-max | 16-734 | 14-168 | 28-50 | 7-55 | 7-734 |
Time to Cmax is the time to reach peak CAR-T concentration. (Only summarized for patients with PET-positive disease before preconditioning.)
AUC, area under the curve; Tlast, time to last measurable in blood (days); Tmax, time to Cmax (days).