Top 10 increased platelet proteins in releasate of resting ERp5 knockout platelets
| . | Protein . | Name . | Log FC . | Average expression . | P . | Adjusted P . | Function . | Intracellular location . |
|---|---|---|---|---|---|---|---|---|
| 1 | Smtn | Smoothelin | 2.3 | 25.9 | .0004 | .1376 | Structural protein, stress fibers | Cytoskeleton |
| 2 | Vapb | Vesicle-associated membrane protein–associated protein B | 2.0 | 26.1 | .0007 | .1376 | Vesicle trafficking | Vesicular membranes, cytoplasm |
| 3 | Hyou1 | Hypoxia upregulated protein 1 | 1.8 | 30.2 | .0008 | .1376 | Hypoxia upregulated, ER stress | ER |
| 4 | Eif3b | Eukaryotic translation initiation factor 3 subunit B | 3.0 | 26.7 | .0009 | .1376 | Initiation of messenger RNA translation | Cytoplasm |
| 5 | Psmc2 | 26S protease regulatory subunit 7 | 1.8 | 27.0 | .001 | .1376 | Adenosine triphosphate–dependent degradation of ubiquitinated proteins | cytoplasm |
| 6 | Pdia4 (ERp72) | Protein disulfide isomerase A4 | 1.4 | 31.3 | .0012 | .1376 | Disulfide isomerase | ER |
| 7 | Tmed3 | Transmembrane emp24 domain-containing protein 3 | 1.7 | 26.1 | .0013 | .1376 | Vesicular protein trafficking | ER, Golgi |
| 8 | Srm | Spermidine synthase | 1.5 | 27.5 | .0014 | .1376 | Polyamine biosynthesis | Cytoplasm |
| 9 | Cul1 | Cullin-1 | 2.5 | 23.6 | .0015 | .1376 | Protein ubiquitination | Cytoplasm |
| 10 | Cdv3 | Protein Cdv3 | 1.6 | 26.5 | .0016 | .1376 | Unknown, related to platelet activation37 | Cytoplasm |
| . | Protein . | Name . | Log FC . | Average expression . | P . | Adjusted P . | Function . | Intracellular location . |
|---|---|---|---|---|---|---|---|---|
| 1 | Smtn | Smoothelin | 2.3 | 25.9 | .0004 | .1376 | Structural protein, stress fibers | Cytoskeleton |
| 2 | Vapb | Vesicle-associated membrane protein–associated protein B | 2.0 | 26.1 | .0007 | .1376 | Vesicle trafficking | Vesicular membranes, cytoplasm |
| 3 | Hyou1 | Hypoxia upregulated protein 1 | 1.8 | 30.2 | .0008 | .1376 | Hypoxia upregulated, ER stress | ER |
| 4 | Eif3b | Eukaryotic translation initiation factor 3 subunit B | 3.0 | 26.7 | .0009 | .1376 | Initiation of messenger RNA translation | Cytoplasm |
| 5 | Psmc2 | 26S protease regulatory subunit 7 | 1.8 | 27.0 | .001 | .1376 | Adenosine triphosphate–dependent degradation of ubiquitinated proteins | cytoplasm |
| 6 | Pdia4 (ERp72) | Protein disulfide isomerase A4 | 1.4 | 31.3 | .0012 | .1376 | Disulfide isomerase | ER |
| 7 | Tmed3 | Transmembrane emp24 domain-containing protein 3 | 1.7 | 26.1 | .0013 | .1376 | Vesicular protein trafficking | ER, Golgi |
| 8 | Srm | Spermidine synthase | 1.5 | 27.5 | .0014 | .1376 | Polyamine biosynthesis | Cytoplasm |
| 9 | Cul1 | Cullin-1 | 2.5 | 23.6 | .0015 | .1376 | Protein ubiquitination | Cytoplasm |
| 10 | Cdv3 | Protein Cdv3 | 1.6 | 26.5 | .0016 | .1376 | Unknown, related to platelet activation37 | Cytoplasm |
Protein function data have been sourced from UniProt and PubMed.
Log FC, log fold change.