Prognostication tools in HSCT: classification and recommendations for clinical use
| . | Prognostication sector . | Prognostication area . | Model/factor . | Specific diseases . |
|---|---|---|---|---|
| Required | Patient factors | Comorbidity burden | HCT-CI | — |
| Performance status | KPS | — | ||
| Disease factors | Disease risk index | R-DRI | — | |
| Transplant factors | Donor | Type and HLA-matching | — | |
| Regimens | Conditioning intensity and GVHD prophylaxis | — | ||
| Physician | Subjective | Educated and experience-based perception | — | |
| Highly recommended | Patient factors | Gait speed | 4-meter walk test | — |
| Disease factors | Disease-specific models | ELN-2022 | AML | |
| IPSS-M | MDS | |||
| MIPSS70+ | Primary MF | |||
| CPSS-Mol | CMML | |||
| MRD | PCR or multiparameter flow cytometry | AML or ALL | ||
| Considered | Patient factors | Age | Calendar | — |
| Geriatric assessment | IADL | — | ||
| ADL | — | |||
| Depression | — | |||
| Cognitive impairments | — | |||
| Social vulnerability | — | |||
| Mixed factors | Global models | Revised PAM | — | |
| Modified EBMT | — | |||
| EASIX | — | |||
| Academic interest | Patient factors | Combination models | HCT-CI/IADL | — |
| Mixed factors | HCT-CR | — | ||
| HCT-CI/EBMT | — | |||
| Mixed factors | Global models | TRM | — | |
| AML-CM | — | |||
| NRM-J | — |
| . | Prognostication sector . | Prognostication area . | Model/factor . | Specific diseases . |
|---|---|---|---|---|
| Required | Patient factors | Comorbidity burden | HCT-CI | — |
| Performance status | KPS | — | ||
| Disease factors | Disease risk index | R-DRI | — | |
| Transplant factors | Donor | Type and HLA-matching | — | |
| Regimens | Conditioning intensity and GVHD prophylaxis | — | ||
| Physician | Subjective | Educated and experience-based perception | — | |
| Highly recommended | Patient factors | Gait speed | 4-meter walk test | — |
| Disease factors | Disease-specific models | ELN-2022 | AML | |
| IPSS-M | MDS | |||
| MIPSS70+ | Primary MF | |||
| CPSS-Mol | CMML | |||
| MRD | PCR or multiparameter flow cytometry | AML or ALL | ||
| Considered | Patient factors | Age | Calendar | — |
| Geriatric assessment | IADL | — | ||
| ADL | — | |||
| Depression | — | |||
| Cognitive impairments | — | |||
| Social vulnerability | — | |||
| Mixed factors | Global models | Revised PAM | — | |
| Modified EBMT | — | |||
| EASIX | — | |||
| Academic interest | Patient factors | Combination models | HCT-CI/IADL | — |
| Mixed factors | HCT-CR | — | ||
| HCT-CI/EBMT | — | |||
| Mixed factors | Global models | TRM | — | |
| AML-CM | — | |||
| NRM-J | — |
CPSS-Mol, Chronic Myelomonocytic Leukemia–Specific Prognostic Scoring System with Molecular Features; IPSS-M, International Prognostic Scoring System (Molecular); MF, myelofibrosis; MIPSS70+, Mutation and Karyotype-Enhanced International Prognostic Scoring System; PCR, polymerase chain reaction.