Overview of patient HLH criteria
| . | Patient . | Norm . | HLH criteria . |
|---|---|---|---|
| Fever | Yes | <38.5°C | Yes |
| Splenomegaly | Yes | — | Yes |
| Hemoglobin, g/L | 80∗ | 92-150 | <90 |
| Platelets × 109/L | 140∗ | 150-500 | <150 |
| Neutrophil count × 109/L | 1.5 | 1.3-7.9 | <1 |
| Ferritin, μg/L | 1465 | 7-140 | >500 |
| Triglycerides, mg/dL | 205∗ | 70-180 | >265 |
| Soluble Il2 receptor, U/mL | 7119 | <623 | >2400 |
| Fibrinogen, g/L | 1.9 | 1.5-3.5 | <1.5 |
| D dimers, mg/L | 1.8 | <0.5 | — |
| Bone marrow aspirate | Not done | — | Hemophagocytosis |
| HLA-DR expression of T cells†, % | 25 | 2-8 | — |
| . | Patient . | Norm . | HLH criteria . |
|---|---|---|---|
| Fever | Yes | <38.5°C | Yes |
| Splenomegaly | Yes | — | Yes |
| Hemoglobin, g/L | 80∗ | 92-150 | <90 |
| Platelets × 109/L | 140∗ | 150-500 | <150 |
| Neutrophil count × 109/L | 1.5 | 1.3-7.9 | <1 |
| Ferritin, μg/L | 1465 | 7-140 | >500 |
| Triglycerides, mg/dL | 205∗ | 70-180 | >265 |
| Soluble Il2 receptor, U/mL | 7119 | <623 | >2400 |
| Fibrinogen, g/L | 1.9 | 1.5-3.5 | <1.5 |
| D dimers, mg/L | 1.8 | <0.5 | — |
| Bone marrow aspirate | Not done | — | Hemophagocytosis |
| HLA-DR expression of T cells†, % | 25 | 2-8 | — |
The patient displayed moderate immune dysregulation in the context of a cytomegalovirus infection, meeting 4 (bold print) out of 8 HLH criteria.
HLA-DR, Human Leukocyte Antigen–DR isotype.
Parameters were outside the norm not formally fulfilling the cutoff of the respective criterion.
T cells were substantially activated (elevated HLA-DR expression and soluble IL2 receptor), exceeding appropriate antiviral response.