Table 4.

Multivariable logistic regression analysis of predictors for CM-TMA recurrence after eculizumab discontinuation

Odds ratio (95% CI)Level P valueOverall P value
Age, per 10-y decrease 1.248 (1.024-1.523) — .029 
Transplant (vs native) 4.287 (1.428-12.866) — .009 
Variant of highest pathogenicity   < .001 
CFH (vs none) 14.561 (5.659-37.469) < .001  
C3 (vs none) 9.385 (2.586-34.069) < .001  
MCP/CD46 (vs none) 6.413 (2.413-17.047) < .001  
Other/variant not specified (vs none) 2.002 (0.753-5.318) .164  
Odds ratio (95% CI)Level P valueOverall P value
Age, per 10-y decrease 1.248 (1.024-1.523) — .029 
Transplant (vs native) 4.287 (1.428-12.866) — .009 
Variant of highest pathogenicity   < .001 
CFH (vs none) 14.561 (5.659-37.469) < .001  
C3 (vs none) 9.385 (2.586-34.069) < .001  
MCP/CD46 (vs none) 6.413 (2.413-17.047) < .001  
Other/variant not specified (vs none) 2.002 (0.753-5.318) .164  
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