Table 2. Relapse rates according to... | American Society of Hematology

Table 2.

Relapse rates according to complement gene variants and complement antibodies

	N	n	Relapse	Relapse rate, %
Overall	280	—	83	29.6
No variant detected	112	—	12	10.7
Variant detected	168	—	71	42.3
>1 concomitant variants	20	—	10	50.0
CFH-inclusive	—	12	6	50.0
Non CFH-inclusive	—	8	4	50.0
Single-gene variants	148	—	61	41.2
CFH	47	—	27	57.4
Exon 22	—	11	10	90.9
NOS	—	19	7	36.8
Other	—	17	10	58.8
MCP/CD46	35	—	18	51.4
Splice regions	—	12	10	83.3
NOS	—	9	3	33.3
Other	—	14	5	35.7
C3	11	—	5	45.5
CFI	15	—	5	33.3
Anti-CFH antibodies	12	—	2	16.7
Other single variants	13∗	—	4	30.8
Variant NOS	15	—	0	0.00
CFHvariant type†	28	—	—	—
Missense variants	—	18	14	77.8
Non-missense variants	—	10	6	60.0
MCP/CD46variant type†	26	—	—	—
Non-splice region	—	14	5	35.7
Canonical splice region	—	12	10	83.3

	N	n	Relapse	Relapse rate, %
Overall	280	—	83	29.6
No variant detected	112	—	12	10.7
Variant detected	168	—	71	42.3
>1 concomitant variants	20	—	10	50.0
CFH-inclusive	—	12	6	50.0
Non CFH-inclusive	—	8	4	50.0
Single-gene variants	148	—	61	41.2
CFH	47	—	27	57.4
Exon 22	—	11	10	90.9
NOS	—	19	7	36.8
Other	—	17	10	58.8
MCP/CD46	35	—	18	51.4
Splice regions	—	12	10	83.3
NOS	—	9	3	33.3
Other	—	14	5	35.7
C3	11	—	5	45.5
CFI	15	—	5	33.3
Anti-CFH antibodies	12	—	2	16.7
Other single variants	13∗	—	4	30.8
Variant NOS	15	—	0	0.00
CFHvariant type†	28	—	—	—
Missense variants	—	18	14	77.8
Non-missense variants	—	10	6	60.0
MCP/CD46variant type†	26	—	—	—
Non-splice region	—	14	5	35.7
Canonical splice region	—	12	10	83.3

Other single variants are CFHR1-5 deletions without autoantibodies (n = 8) and variants in ADAMTS13 (n = 2), CFB (n = 2), and DGKE (n = 1).

Only includes patients with listed variant as a single variant.