Mucositis during dose escalation
| Dose level . | Patient . | Day 7 . | Day 14 . | Day 21 . | Day 28 . |
|---|---|---|---|---|---|
| Level 1, 6 Gy | 1–1 | Grade 0 | Grade 0 | Grade 0 | Grade 0 |
| 1–2 | Grade 0 | Grade 0 | Grade 0 | Grade 0 | |
| 1–3 | Grade 1 | Grade 0 | Grade 0 | Grade 0 | |
| 1–4 | Grade 1 | Grade 0 | Grade 1 | Grade 0 | |
| 1–5 | Grade 0 | Grade 0 | Grade 0 | Grade 0 | |
| Level 2, 9 Gy | 2–1 | Grade 3 | Grade 2 | Grade 0 | Grade 0 |
| 2–2 | Grade 1 | Grade1 | Grade0 | Grade 0 | |
| 2–3 | Grade 1 | Grade 0 | Grade 0 | Grade 0 | |
| 2–4 | Grade 0 | Grade 0 | Grade 0 | Grade 0 | |
| 2–5 | Grade 1 | Grade 0 | Grade 0 | Grade 0 | |
| 2–6 | Grade 0 | Grade 0 | Grade 0 | Grade 0 | |
| 2–7 | Grade 1 | Grade 1 | Grade 1 | Grade 1 | |
| 2–8 | Grade: 0 | Grade: 0 | Grade 0 | Grade 0 | |
| 2–9 | Grade 0 | Grade 0 | Grade 0 | Grade 0 | |
| 2–10 | Grade: 3 | Grade 2 | Grade: 0 | Grade 0 | |
| Level 3, 12 Gy | 3–1 | Grade 0 | Grade 0 | Grade 0 | Grade 0 |
| 3–2 | Grade 1 | Grade 0 | Grade 0 | Grade 0 | |
| 3–3 | Grade 3 | Grade 0 | Grade 0 | Grade 0 | |
| 3–4 | Grade 0 | Grade 0 | Grade 1 | Grade 0 | |
| 3–5 | Grade 0 | Grade 0 | Grade 0 | Grade 0 | |
| 3–6 | Grade: 2 | Grade: 3 | Grade: 4 | Grade: 0 |
| Dose level . | Patient . | Day 7 . | Day 14 . | Day 21 . | Day 28 . |
|---|---|---|---|---|---|
| Level 1, 6 Gy | 1–1 | Grade 0 | Grade 0 | Grade 0 | Grade 0 |
| 1–2 | Grade 0 | Grade 0 | Grade 0 | Grade 0 | |
| 1–3 | Grade 1 | Grade 0 | Grade 0 | Grade 0 | |
| 1–4 | Grade 1 | Grade 0 | Grade 1 | Grade 0 | |
| 1–5 | Grade 0 | Grade 0 | Grade 0 | Grade 0 | |
| Level 2, 9 Gy | 2–1 | Grade 3 | Grade 2 | Grade 0 | Grade 0 |
| 2–2 | Grade 1 | Grade1 | Grade0 | Grade 0 | |
| 2–3 | Grade 1 | Grade 0 | Grade 0 | Grade 0 | |
| 2–4 | Grade 0 | Grade 0 | Grade 0 | Grade 0 | |
| 2–5 | Grade 1 | Grade 0 | Grade 0 | Grade 0 | |
| 2–6 | Grade 0 | Grade 0 | Grade 0 | Grade 0 | |
| 2–7 | Grade 1 | Grade 1 | Grade 1 | Grade 1 | |
| 2–8 | Grade: 0 | Grade: 0 | Grade 0 | Grade 0 | |
| 2–9 | Grade 0 | Grade 0 | Grade 0 | Grade 0 | |
| 2–10 | Grade: 3 | Grade 2 | Grade: 0 | Grade 0 | |
| Level 3, 12 Gy | 3–1 | Grade 0 | Grade 0 | Grade 0 | Grade 0 |
| 3–2 | Grade 1 | Grade 0 | Grade 0 | Grade 0 | |
| 3–3 | Grade 3 | Grade 0 | Grade 0 | Grade 0 | |
| 3–4 | Grade 0 | Grade 0 | Grade 1 | Grade 0 | |
| 3–5 | Grade 0 | Grade 0 | Grade 0 | Grade 0 | |
| 3–6 | Grade: 2 | Grade: 3 | Grade: 4 | Grade: 0 |
Mucositis, 1 of the primary DLT, was graded on the World Health Organization Mucositis Scale at days 7, 14, 21, and 28 posttransplant.