Assay kits used by the participating laboratories in each country and corresponding interlaboratory variability
| Assay kit . | Australia . | Canada . | Czech Republic . | France . | Germany . | Italy . | The Netherlands . | South Africa . | Sweden . | United Kingdom . | United States . | Total Labs . | Interlaboratory CV (%)∗ . | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| rR338L-FIX . | WHO (Fifth IS) . | SSC lot #4 . | |||||||||||||
| PTT Automate | 1 | — | — | 1 | — | — | — | 1 | — | — | — | 3 | 10 | 2 | 5 |
| TriniCLOT aPTT S | 1 | — | — | — | — | — | — | — | — | — | — | 1 | 1∗ | 2∗ | 2∗ |
| TriniCLOT aPTT HS | — | — | — | 1 | — | — | — | — | — | 2 | — | 3 | 7 | 6 | 8 |
| Cephascreen | — | — | 1 | 1 | — | — | 1 | — | — | — | — | 3 | 17 | 8 | 12 |
| APTT-SP | 1 | — | — | — | — | — | — | — | — | 2 | — | 3 | 13 | 16 | 25 |
| PPT-LA | — | — | — | — | — | — | 1 | — | — | — | — | 1 | 18∗ | 19∗ | 21∗ |
| CK Prest | — | — | — | 3 | — | — | — | — | — | 1 | — | 4 | 3 | 5 | 4 |
| SynthASil | 1 | 1 | — | 1 | — | 1 | — | — | — | 3 | 3 | 10 | 6 | 11 | 8 |
| ACTIN-FS | 2 | 2 | — | 1 | — | — | — | — | — | 6 | — | 11 | 11 | 11 | 11 |
| Actin | — | — | — | — | — | — | — | — | — | 1 | — | 1 | 11∗ | 8∗ | 6∗ |
| Pathromtin | — | — | 3 | — | 1 | — | — | — | — | 3 | — | 7 | 7 | 10 | 11 |
| SynthAFax | — | 2 | — | — | — | — | — | — | — | 7 | 1 | 10 | 11 | 8 | 7 |
| Actin-FSL | 1 | — | 1 | — | — | — | — | — | — | 3 | 2 | 7 | 9 | 7 | 11 |
| ROX FIX (Rossix)† | — | 1 | — | 1 | 1 | 1 | — | — | 1 | 4 | 2 | 11 | 23 | 13 | 9 |
| Biophen FIX (Hyphen)† | 1 | 1 | 1 | 1 | — | — | 1 | — | — | 3 | — | 8 | 15 | 8 | 7 |
| Assay kit . | Australia . | Canada . | Czech Republic . | France . | Germany . | Italy . | The Netherlands . | South Africa . | Sweden . | United Kingdom . | United States . | Total Labs . | Interlaboratory CV (%)∗ . | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| rR338L-FIX . | WHO (Fifth IS) . | SSC lot #4 . | |||||||||||||
| PTT Automate | 1 | — | — | 1 | — | — | — | 1 | — | — | — | 3 | 10 | 2 | 5 |
| TriniCLOT aPTT S | 1 | — | — | — | — | — | — | — | — | — | — | 1 | 1∗ | 2∗ | 2∗ |
| TriniCLOT aPTT HS | — | — | — | 1 | — | — | — | — | — | 2 | — | 3 | 7 | 6 | 8 |
| Cephascreen | — | — | 1 | 1 | — | — | 1 | — | — | — | — | 3 | 17 | 8 | 12 |
| APTT-SP | 1 | — | — | — | — | — | — | — | — | 2 | — | 3 | 13 | 16 | 25 |
| PPT-LA | — | — | — | — | — | — | 1 | — | — | — | — | 1 | 18∗ | 19∗ | 21∗ |
| CK Prest | — | — | — | 3 | — | — | — | — | — | 1 | — | 4 | 3 | 5 | 4 |
| SynthASil | 1 | 1 | — | 1 | — | 1 | — | — | — | 3 | 3 | 10 | 6 | 11 | 8 |
| ACTIN-FS | 2 | 2 | — | 1 | — | — | — | — | — | 6 | — | 11 | 11 | 11 | 11 |
| Actin | — | — | — | — | — | — | — | — | — | 1 | — | 1 | 11∗ | 8∗ | 6∗ |
| Pathromtin | — | — | 3 | — | 1 | — | — | — | — | 3 | — | 7 | 7 | 10 | 11 |
| SynthAFax | — | 2 | — | — | — | — | — | — | — | 7 | 1 | 10 | 11 | 8 | 7 |
| Actin-FSL | 1 | — | 1 | — | — | — | — | — | — | 3 | 2 | 7 | 9 | 7 | 11 |
| ROX FIX (Rossix)† | — | 1 | — | 1 | 1 | 1 | — | — | 1 | 4 | 2 | 11 | 23 | 13 | 9 |
| Biophen FIX (Hyphen)† | 1 | 1 | 1 | 1 | — | — | 1 | — | — | 3 | — | 8 | 15 | 8 | 7 |
CV, coefficient of variation; FIX, factor IX; FIX:C, FIX activity; IS, International Standard; r, recombinant; SSC, Scientific and Standardization Committee of the International Society on Thrombosis and Haemostasis; WHO, World Health Organization.
CV% in these cases are intralaboratory CV.
Denotes assays that were only performed at 1 laboratory.
Highlights chromogenic FIX:C assays.