Multivariate analysis for risk factors of first bleeding
| Predictors . | Major bleeding . | Clinically relevant nonmajor bleeding . | ||
|---|---|---|---|---|
| Adjusted SHR∗ (95% CI) . | P . | Adjusted SHR∗ (95% CI) . | P . | |
| Patient age, per year | 0.99 (0.96-1.02) | .639 | 1.02 (0.99-1.04) | .155 |
| Male sex | 0.92 (0.59-1.44) | .710 | 1.17 (0.82-1.67) | .391 |
| Arterial hypertension | 0.78 (0.49-1.24) | .291 | 0.96 (0.67-1.37) | .824 |
| Cardiac disease | 1.51 (0.96-2.38) | .075 | 1.14 (0.76-1.70) | .532 |
| Cerebrovascular disease | 0.82 (0.40-1.65) | .575 | 0.91 (0.52-1.62) | .760 |
| Diabetes mellitus | 0.65 (0.34-1.25) | .199 | 1.10 (0.70-1.72) | .681 |
| Chronic renal disease | 1.30 (0.79-2.13) | .299 | 0.99 (0.65-1.51) | .968 |
| Chronic liver disease | 1.65 (0.46-5.87) | .439 | 0.92 (0.18-4.84) | .926 |
| Active cancer | 1.81 (1.12-2.93) | .016 | 1.51 (0.99-2.31) | .056 |
| History of major bleeding | 0.87 (0.45-1.68) | .671 | 1.15 (0.69-1.93) | .588 |
| Recent surgery | 1.41 (0.82-2.45) | .215 | 0.94 (0.53-1.67) | .824 |
| Low physical activity | 1.88 (1.19-2.98) | .007 | 1.00 (0.70-1.44) | .990 |
| High risk of falls | 1.12 (0.71-1.76) | .629 | 2.04 (1.39-3.00) | <.001 |
| Anemia | 1.54 (0.99-2.41) | .056 | 1.23 (0.86-1.75) | .254 |
| Thrombocytopenia | 0.90 (0.49-1.65) | .740 | 1.38 (0.89-2.14) | .156 |
| Concomitant antiplatelet/NSAID therapy | 1.35 (0.85-2.16) | .203 | 1.43 (0.99-2.05) | .055 |
| Predictors . | Major bleeding . | Clinically relevant nonmajor bleeding . | ||
|---|---|---|---|---|
| Adjusted SHR∗ (95% CI) . | P . | Adjusted SHR∗ (95% CI) . | P . | |
| Patient age, per year | 0.99 (0.96-1.02) | .639 | 1.02 (0.99-1.04) | .155 |
| Male sex | 0.92 (0.59-1.44) | .710 | 1.17 (0.82-1.67) | .391 |
| Arterial hypertension | 0.78 (0.49-1.24) | .291 | 0.96 (0.67-1.37) | .824 |
| Cardiac disease | 1.51 (0.96-2.38) | .075 | 1.14 (0.76-1.70) | .532 |
| Cerebrovascular disease | 0.82 (0.40-1.65) | .575 | 0.91 (0.52-1.62) | .760 |
| Diabetes mellitus | 0.65 (0.34-1.25) | .199 | 1.10 (0.70-1.72) | .681 |
| Chronic renal disease | 1.30 (0.79-2.13) | .299 | 0.99 (0.65-1.51) | .968 |
| Chronic liver disease | 1.65 (0.46-5.87) | .439 | 0.92 (0.18-4.84) | .926 |
| Active cancer | 1.81 (1.12-2.93) | .016 | 1.51 (0.99-2.31) | .056 |
| History of major bleeding | 0.87 (0.45-1.68) | .671 | 1.15 (0.69-1.93) | .588 |
| Recent surgery | 1.41 (0.82-2.45) | .215 | 0.94 (0.53-1.67) | .824 |
| Low physical activity | 1.88 (1.19-2.98) | .007 | 1.00 (0.70-1.44) | .990 |
| High risk of falls | 1.12 (0.71-1.76) | .629 | 2.04 (1.39-3.00) | <.001 |
| Anemia | 1.54 (0.99-2.41) | .056 | 1.23 (0.86-1.75) | .254 |
| Thrombocytopenia | 0.90 (0.49-1.65) | .740 | 1.38 (0.89-2.14) | .156 |
| Concomitant antiplatelet/NSAID therapy | 1.35 (0.85-2.16) | .203 | 1.43 (0.99-2.05) | .055 |
Adjustments were done for all other variables and competing risk of death.