Table 2.

Bleeding incidence rates during anticoagulant therapy

No. of patientsBleeds per 100 patient-years (95% CI)
Major bleeding, mo 
0-3 981 21.4 (16.1-28.4) 
0-1 981 44.9 (32.2-62.5) 
1-3 910 8.9 (5.2-15.3) 
3-36 827 5.4 (4.1-7.1) 
3-12 827 7.5 (5.3-10.6) 
12-36 418 3.7 (2.4-5.8) 
Clinically relevant nonmajor bleeding, mo 
0-3 981 22.3 (16.9-29.4) 
0-1 981 33.2 (22.6-48.7) 
1-3 913 16.5 (11.0-24.5) 
3-36 823 11.0 (9.0-13.5) 
3-12 823 14.8 (11.5-19.0) 
12-36 385 7.8 (5.6-10.8) 
No. of patientsBleeds per 100 patient-years (95% CI)
Major bleeding, mo 
0-3 981 21.4 (16.1-28.4) 
0-1 981 44.9 (32.2-62.5) 
1-3 910 8.9 (5.2-15.3) 
3-36 827 5.4 (4.1-7.1) 
3-12 827 7.5 (5.3-10.6) 
12-36 418 3.7 (2.4-5.8) 
Clinically relevant nonmajor bleeding, mo 
0-3 981 22.3 (16.9-29.4) 
0-1 981 33.2 (22.6-48.7) 
1-3 913 16.5 (11.0-24.5) 
3-36 823 11.0 (9.0-13.5) 
3-12 823 14.8 (11.5-19.0) 
12-36 385 7.8 (5.6-10.8) 

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