Patient characteristics
| Number | 163 |
| NIH | 86 |
| CNH | 77 |
| Gender (n, %) | |
| Male | 98 (60%) |
| Female | 65 (40%) |
| Genotype (n, %) | |
| SS | 148 (91%) |
| SB0 | 8 (5%) |
| SB+ | 3 (2%) |
| SC | 4 (2%) |
| Average age at transplant (mean, median [IQR], range) | |
| All | 21.2, 19(22.5), 7 mo-64 y |
| NIH | 31.3, 31(12.8), 10-64 y |
| CNH | 9.8, 9(9), 7 mo-25 y |
| Comorbid conditions (n, %) | |
| Recurrent pain | 89 (55%) |
| Recurrent ACS | 60 (37%) |
| Iron overload | 28 (17%) |
| Renal disease | 29 (18%) |
| Silent cerebral infarct | 23 (14%) |
| Elevated TRV | 23 (14%) |
| Hepatopathy | 22 (13%) |
| Stroke | 21 (13%) |
| Osteonecrosis | 21 (13%) |
| Abnormal TCD | 18 (11%) |
| Recurrent splenic sequestration | 13 (21%) |
| Pulmonary HTN | 12 (7%) |
| Recurrent priapism | 12 (19%) |
| Alloimmunization | 9 (6%) |
| Severe anemia | 8 (5%) |
| Retinopathy | 8 (5%) |
| PE/DVT | 7 (4%) |
| Sepsis | 7 (4%) |
| Cardiac disease | 5 (3%) |
| Other∗ | 3 (2%) |
| Conditioning (n, %) | |
| Myeloablative | 40 (25%) |
| Nonmyeloablative | 123 (75%) |
| Donor (n, %) | |
| Matched sibling | 118 (72%) |
| Haploidentical | 29 (18%) |
| Matched unrelated donor | 7 (4%) |
| Cord blood | 9 (6%) |
| Number | 163 |
| NIH | 86 |
| CNH | 77 |
| Gender (n, %) | |
| Male | 98 (60%) |
| Female | 65 (40%) |
| Genotype (n, %) | |
| SS | 148 (91%) |
| SB0 | 8 (5%) |
| SB+ | 3 (2%) |
| SC | 4 (2%) |
| Average age at transplant (mean, median [IQR], range) | |
| All | 21.2, 19(22.5), 7 mo-64 y |
| NIH | 31.3, 31(12.8), 10-64 y |
| CNH | 9.8, 9(9), 7 mo-25 y |
| Comorbid conditions (n, %) | |
| Recurrent pain | 89 (55%) |
| Recurrent ACS | 60 (37%) |
| Iron overload | 28 (17%) |
| Renal disease | 29 (18%) |
| Silent cerebral infarct | 23 (14%) |
| Elevated TRV | 23 (14%) |
| Hepatopathy | 22 (13%) |
| Stroke | 21 (13%) |
| Osteonecrosis | 21 (13%) |
| Abnormal TCD | 18 (11%) |
| Recurrent splenic sequestration | 13 (21%) |
| Pulmonary HTN | 12 (7%) |
| Recurrent priapism | 12 (19%) |
| Alloimmunization | 9 (6%) |
| Severe anemia | 8 (5%) |
| Retinopathy | 8 (5%) |
| PE/DVT | 7 (4%) |
| Sepsis | 7 (4%) |
| Cardiac disease | 5 (3%) |
| Other∗ | 3 (2%) |
| Conditioning (n, %) | |
| Myeloablative | 40 (25%) |
| Nonmyeloablative | 123 (75%) |
| Donor (n, %) | |
| Matched sibling | 118 (72%) |
| Haploidentical | 29 (18%) |
| Matched unrelated donor | 7 (4%) |
| Cord blood | 9 (6%) |
Other: Lupus (n = 1), Wiskott Aldrich Syndrome (n = 1), returning to Africa (n = 1)