Table 2.

Unadjusted and adjusted 90-day post hospital VTE incidence by SARS-CoV-2 positivity and study period (n=63 920)

SARS-CoV-2 periodSARS-CoV-2 (−) n=50 393COVID-19 Vaccine breakthrough n=3443COVID-19 Unvaccinated n=10 084
(Reference)UnadjustedAdjusted
HR (95% CI)
UnadjustedAdjusted
HR (95% CI)
Pre-Delta n=25 415 0.7% (144/20 644) 3.0% (1/33) 2.9 (0.4-20.9)  1.3% (60/4738) 2.1 (1.6-2.8)  
Delta n=19 296 0.7% (100/14 531) 1.7% (17/1029) 2.2 (1.3-3.6)  2.1% (79/3736) 4.1 (3.1-5.3)§  
Omicron n=19 209 0.7% (99/15 218) 0.9% (22/2381) 1.5 (1.0-2.3)  1.3% (21/1610) 2.2 (1.4-3.4)  
SARS-CoV-2 periodSARS-CoV-2 (−) n=50 393COVID-19 Vaccine breakthrough n=3443COVID-19 Unvaccinated n=10 084
(Reference)UnadjustedAdjusted
HR (95% CI)
UnadjustedAdjusted
HR (95% CI)
Pre-Delta n=25 415 0.7% (144/20 644) 3.0% (1/33) 2.9 (0.4-20.9)  1.3% (60/4738) 2.1 (1.6-2.8)  
Delta n=19 296 0.7% (100/14 531) 1.7% (17/1029) 2.2 (1.3-3.6)  2.1% (79/3736) 4.1 (3.1-5.3)§  
Omicron n=19 209 0.7% (99/15 218) 0.9% (22/2381) 1.5 (1.0-2.3)  1.3% (21/1610) 2.2 (1.4-3.4)  

HRs with 95% CI and P-values presented for Cox regression of 90-day post hospital VTE in COVID-19 subgroups relative to SARS-CoV-2 negative patients.

P = .287.

P < .001.

P = .002.

§

P < .001.

P = .083.

P < .001.

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