Helical parameters for VWF tubules
| VWF variant . | Axial rise per subunit (Å) . | Helical twist (°) . | Pitch (Å) . | Reference . |
|---|---|---|---|---|
| In cells∗ | 27.7 | 83.1 | 120 | 16 |
| D1D2-D′D3 | 26.2 | 85.6 | 110 | 13† |
| D1D2-D′D3 | 28.5 | 86.0 | 119 | 14 |
| D1D2-D′D3 | 29.4 | 86.8 | 122 | 15 |
| D1D2-D′D3A1∗ | 27.6 | 83.1 | 120 | This work |
| D1D2-D′D3A1A2A3 | 27.6 | 82.6 | 120 | This work |
| D1D2D′D3A1 R763G | 28.1 | 82.6 | 122 | This work |
| VWF variant . | Axial rise per subunit (Å) . | Helical twist (°) . | Pitch (Å) . | Reference . |
|---|---|---|---|---|
| In cells∗ | 27.7 | 83.1 | 120 | 16 |
| D1D2-D′D3 | 26.2 | 85.6 | 110 | 13† |
| D1D2-D′D3 | 28.5 | 86.0 | 119 | 14 |
| D1D2-D′D3 | 29.4 | 86.8 | 122 | 15 |
| D1D2-D′D3A1∗ | 27.6 | 83.1 | 120 | This work |
| D1D2-D′D3A1A2A3 | 27.6 | 82.6 | 120 | This work |
| D1D2D′D3A1 R763G | 28.1 | 82.6 | 122 | This work |
These rows emphasize the close agreement between the high-resolution VWF tubule structure reported in this work and the parameters measured from full-length VWF tubules in WPBs in endothelial cells.
Heterogeneity in pitch was observed in this study. Values in this table correspond to the major bin used for reconstructing the VWF low-resolution structure.