Randomized controlled trials of haplo-SCT vs CBT
| Study title . | Clinical trial identifier . | Institution/country . | Patients, N . | Allocation . | Study period . | Primary outcome measures . | Indication . | Status . | Primary investigator . | References . |
|---|---|---|---|---|---|---|---|---|---|---|
| Haplo SCT vs Haplo-cord SCT for Patients With Hematological Disorders | NCT03719534 | First Affiliated Hospital of Soochow University Suzhou, Jiangsu, China | 100 child, adult | Randomized | 1 June 2017- 31 December 2022 | Estimated OS at 3 y post SCT | Hematologic diseases | Recruiting | Jia Chen M. | |
| A Randomized Multicenter Study Comparing Unrelated Umbilical-cord Blood Transplant Versus Human Leukocyte Antigen (HLA)-Haploidentical Related Hematopoietic Stem Cell Transplant for Adult Patients With Hematologic Malignancies | NCT02386332 | Instituto de Investigacion Sanitaria La Fe, Valencia, Spain | 206 adults, ≥18 and ≤55 y | 11 March 2015-March 2020 | DFS (time frame: 2 y) | Hematologic malignancies | Unknown | Sanz MA | Sanz et al18 | |
| A Multi-Center, Phase III, Randomized Trial of RIC and Transplantation of (dUCB) Versus HLA-Haplo Related Bone Marrow for Patients With Hematologic Malignancies | NCT01597778 | CIBMTR, Medical College of Wisconsin, US University of Alabama at Birmingham, Birmingham, AL, US Arizona Cancer Center, Phoenix, AZ, US City of Hope National Medical Center, Duarte, CA, US (and 35 more) | 368 adult, older adult (18 y to 70 y) | Randomized | 12 May 2012-11 September 2020 | Percentage of participants with PFS (time frame: 2 y) | AML ALL Burkitt lymphoma Follicular lymphoma Hodgkin lymphoma Mantle cell lymphoma Non-Hodgkin lymphoma | Completed | Horowitz M | Fuchs et al15 Brunstein et al16 |
| An Observational Cohort Study on Transplant-Related Mortality in Patients Receiving Either a Hematopoietic Stem Cell Transplantation Without ATIR or an Umbilical Cord Blood Transplantation | NCT02188290 | Ohio State University Comprehensive Cancer Center, Columbus, OH, US Algemeen Ziekenhuis Sint-Jan, Brugge, Belgium Institut Jules Bordet, Brussels, Belgium Universitair Ziekenhuis Gasthuisberg, Leuven, Belgium Hamilton Niagara Regional Haemophilia Centre, Hamilton, Ontario, Canada (and 5 more) | 178 adult, older adult (18 y to 65 y) | Retrospective | September 2014- 6 October 2015 | Transplant-related mortality (time frame: up to 12 mo after transplantation) | AML ALL MDS | Completed | Rovers J |
| Study title . | Clinical trial identifier . | Institution/country . | Patients, N . | Allocation . | Study period . | Primary outcome measures . | Indication . | Status . | Primary investigator . | References . |
|---|---|---|---|---|---|---|---|---|---|---|
| Haplo SCT vs Haplo-cord SCT for Patients With Hematological Disorders | NCT03719534 | First Affiliated Hospital of Soochow University Suzhou, Jiangsu, China | 100 child, adult | Randomized | 1 June 2017- 31 December 2022 | Estimated OS at 3 y post SCT | Hematologic diseases | Recruiting | Jia Chen M. | |
| A Randomized Multicenter Study Comparing Unrelated Umbilical-cord Blood Transplant Versus Human Leukocyte Antigen (HLA)-Haploidentical Related Hematopoietic Stem Cell Transplant for Adult Patients With Hematologic Malignancies | NCT02386332 | Instituto de Investigacion Sanitaria La Fe, Valencia, Spain | 206 adults, ≥18 and ≤55 y | 11 March 2015-March 2020 | DFS (time frame: 2 y) | Hematologic malignancies | Unknown | Sanz MA | Sanz et al18 | |
| A Multi-Center, Phase III, Randomized Trial of RIC and Transplantation of (dUCB) Versus HLA-Haplo Related Bone Marrow for Patients With Hematologic Malignancies | NCT01597778 | CIBMTR, Medical College of Wisconsin, US University of Alabama at Birmingham, Birmingham, AL, US Arizona Cancer Center, Phoenix, AZ, US City of Hope National Medical Center, Duarte, CA, US (and 35 more) | 368 adult, older adult (18 y to 70 y) | Randomized | 12 May 2012-11 September 2020 | Percentage of participants with PFS (time frame: 2 y) | AML ALL Burkitt lymphoma Follicular lymphoma Hodgkin lymphoma Mantle cell lymphoma Non-Hodgkin lymphoma | Completed | Horowitz M | Fuchs et al15 Brunstein et al16 |
| An Observational Cohort Study on Transplant-Related Mortality in Patients Receiving Either a Hematopoietic Stem Cell Transplantation Without ATIR or an Umbilical Cord Blood Transplantation | NCT02188290 | Ohio State University Comprehensive Cancer Center, Columbus, OH, US Algemeen Ziekenhuis Sint-Jan, Brugge, Belgium Institut Jules Bordet, Brussels, Belgium Universitair Ziekenhuis Gasthuisberg, Leuven, Belgium Hamilton Niagara Regional Haemophilia Centre, Hamilton, Ontario, Canada (and 5 more) | 178 adult, older adult (18 y to 65 y) | Retrospective | September 2014- 6 October 2015 | Transplant-related mortality (time frame: up to 12 mo after transplantation) | AML ALL MDS | Completed | Rovers J |
Data used with permission from ClinicalTrials.gov.
ATIR, haploidentical, naive cell-enriched T-cell product, depleted of recipient-alloreactive T cells.40