Types of hemolytic anemia
| Intrinsic | Membrane/cytoskeletal abnormalities— hereditary spherocytosis Enzyme defects—G6PD, pyruvate kinase deficiency Hgb defects—thalassemia, sickle cell disease |
| Extrinsic | |
| Nonimmune | Increased shear—artificial valves DIC, TTP, HUS Infection—malaria, babesiosis Oxidative stress—dapsone, rasburicase Liver failure—spur cell anemia Hypersplenism |
| Immune | AIHA Cold antibody—cold AIHA: cold agglutinin disease, cold agglutinin syndromea Warm antibody—wAIHAb Mixed |
| Intrinsic | Membrane/cytoskeletal abnormalities— hereditary spherocytosis Enzyme defects—G6PD, pyruvate kinase deficiency Hgb defects—thalassemia, sickle cell disease |
| Extrinsic | |
| Nonimmune | Increased shear—artificial valves DIC, TTP, HUS Infection—malaria, babesiosis Oxidative stress—dapsone, rasburicase Liver failure—spur cell anemia Hypersplenism |
| Immune | AIHA Cold antibody—cold AIHA: cold agglutinin disease, cold agglutinin syndromea Warm antibody—wAIHAb Mixed |