Comparative analyses of full and MRD-negative phase 2 with CIBMTR cohorts for GVHD, relapse, and TRM
| Outcome . | HR . | 95% CI, lower limit . | 95% CI, upper limit . | P . | Overall P . | n . |
|---|---|---|---|---|---|---|
| KIR cohort and CIBMTR cohort | ||||||
| aGVHD 2-4 | ||||||
| Donor type | ||||||
| Haploidentical | 1.00 | — | — | — | .0001 | 46 |
| HLA-identical sibling | 2.186 | 0.834 | 5.729 | .1117 | 104 | |
| Well-matched URD | 4.093 | 1.626 | 10.302 | .0028 | 119 | |
| Partially matched URD | 4.587 | 1.713 | 12.286 | .0024 | 45 | |
| CB | 4.907 | 2.00 | 12.039 | .0005 | 254 | |
| aGVHD 3-4 | ||||||
| Donor type | ||||||
| Haploidentical | 1.00 | — | — | — | .0062 | 46 |
| HLA-identical sibling | 2.633 | 0.316 | 21.95 | .371 | 104 | |
| Well-matched URD | 10.214 | 1.37 | 76.172 | .0234 | 119 | |
| Partially matched URD | 11.374 | 1.458 | 88.731 | .0204 | 45 | |
| CB | 8.129 | 1.11 | 59.526 | .0391 | 254 | |
| Race | ||||||
| White | 1.00 | — | — | — | .045 | 360 |
| Black | 2.087 | 1.206 | 3.61 | .0086 | 79 | |
| Others | 0.963 | 0.47 | 1.972 | .9183 | 75 | |
| Data missing | 0.834 | 0.33 | 2.109 | .7008 | 54 | |
| Disease | ||||||
| AML | 1.00 | — | — | — | .016 | 272 |
| ALL | 1.75 | 1.11 | 2.76 | .016 | 296 | |
| cGVHD | ||||||
| Donor type | ||||||
| Haploidentical | 1.00 | — | — | — | <.0001 | 46 |
| HLA-identical sibling | 2.932 | 1.079 | 7.966 | .0349 | 521 | |
| Well-matched URD | 4.508 | 1.668 | 12.181 | .003 | 659 | |
| Partially matched URD | 5.108 | 1.862 | 14.01 | .0015 | 212 | |
| CB | 3.362 | 1.233 | 9.166 | .0178 | 408 | |
| Ethnicity | .0004 | |||||
| Hispanic | 1.00 | — | — | — | 568 | |
| Non-Hispanic | 0.657 | 0.53 | 0.814 | .0001 | 1200 | |
| Data missing | 0.627 | 0.377 | 1.041 | .071 | 78 | |
| Race | ||||||
| White | 1.00 | — | — | — | <.0001 | 1340 |
| Black | 2.115 | 1.567 | 2.856 | <.0001 | 145 | |
| Others | 1.633 | 1.21 | 2.204 | .0013 | 159 | |
| Data missing | 0.863 | 0.615 | 1.211 | .3938 | 202 | |
| Relapse | ||||||
| Donor type | ||||||
| Haploidentical | 1.00 | — | — | — | .1447 | 46 |
| HLA-identical sibling | 1.794 | 0.84 | 3.835 | .1313 | 526 | |
| Well-matched URD | 1.519 | 0.712 | 3.241 | .28 | 665 | |
| Partially matched URD | 1.261 | 0.565 | 2.814 | .5706 | 216 | |
| CB | 1.738 | 0.808 | 3.737 | .157 | 412 | |
| Disease | ||||||
| AML | 1.00 | — | — | — | <.0001 | 876 |
| ALL | 0.626 | 0.519 | 0.755 | <.0001 | 989 | |
| TRM | ||||||
| Donor type | ||||||
| Haploidentical | 1.00 | — | — | — | <.0001 | 46 |
| HLA-identical sibling | 0.749 | 0.263 | 2.135 | .5885 | 526 | |
| Well-matched URD | 1.223 | 0.441 | 3.393 | .6995 | 665 | |
| Partially matched URD | 2.93 | 1.047 | 8.2 | .0406 | 216 | |
| CB | 1.743 | 0.629 | 4.831 | .2855 | 412 | |
| Ethnicity | ||||||
| Hispanic | 1.00 | — | — | — | .0223 | 569 |
| Non-Hispanic | 0.658 | 0.483 | 0.897 | .008 | 1215 | |
| Data missing | 0.563 | 0.243 | 1.302 | .1791 | 81 | |
| Disease | ||||||
| AML | 1.00 | — | — | — | .0155 | 876 |
| ALL | 1.465 | 1.075 | 1.995 | .0155 | 989 | |
| KPS | ||||||
| ≥90% | 1.00 | — | — | — | <.0001 | 1606 |
| <90% | 2.039 | 1.44 | 2.885 | <.0001 | 259 | |
| MRD− KIR cohort and MRD− CIBMTR cohort | ||||||
| Donor type | ||||||
| Haploidentical | 1.00 | — | — | — | .0016 | 42 |
| HLA-identical sibling | 2.125 | 0.789 | 5.725 | .1359 | 74 | |
| Well-matched URD | 3.87 | 1.516 | 9.879 | .0047 | 86 | |
| Partially matched URD | 2.826 | 0.925 | 8.64 | .0684 | 27 | |
| CB | 4.485 | 1.812 | 11.099 | .0012 | 177 | |
| Donor type | ||||||
| Haploidentical | 1.00 | — | — | — | .004 | 42 |
| HLA-identical sibling | 1.817 | 0.189 | 17.477 | .6052 | 74 | |
| Well-matched URD | 12.588 | 1.688 | 93.848 | .0135 | 86 | |
| Partially matched URD | 7.675 | 0.856 | 68.855 | .0687 | 27 | |
| CB | 7.345 | 0.993 | 54.355 | .0509 | 177 | |
| Disease | ||||||
| AML | 1.00 | — | — | — | .0213 | 188 |
| ALL | 1.93 | 1.103 | 3.379 | .0213 | 218 | |
| Donor type | ||||||
| Haploidentical | 1.00 | — | — | — | .0002 | 42 |
| HLA-identical sibling | 2.525 | 0.922 | 6.919 | .0716 | 374 | |
| Well-matched URD | 4.224 | 1.556 | 11.469 | .0047 | 471 | |
| Partially matched URD | 4.617 | 1.66 | 12.844 | .0034 | 147 | |
| CB | 3.19 | 1.161 | 8.764 | .0245 | 296 | |
| Ethnicity | .0013 | |||||
| Hispanic | 1.00 | — | — | — | 401 | |
| Non-Hispanic | 0.647 | 0.499 | 0.839 | .001 | 874 | |
| Data missing | 0.455 | 0.229 | 0.905 | .0247 | 55 | |
| Race | ||||||
| White | 1.00 | — | — | — | .0001 | 965 |
| Black | 2.059 | 1.432 | 2.96 | <.0001 | 104 | |
| Others | 1.737 | 1.205 | 2.503 | .0031 | 108 | |
| Data missing | 1.015 | 0.692 | 1.487 | .9405 | 153 | |
| Donor type | ||||||
| Haploidentical | 1.00 | — | — | — | .0604 | 42 |
| HLA-identical sibling | 2.642 | 0.971 | 7.191 | .0572 | 378 | |
| Well-matched URD | 2.219 | 0.816 | 6.033 | .1183 | 478 | |
| Partially matched URD | 1.499 | 0.514 | 4.37 | .4588 | 149 | |
| CB | 2.506 | 0.914 | 6.869 | .0741 | 298 | |
| Disease | ||||||
| AML | 1.00 | — | — | — | <.0001 | 609 |
| ALL | 0.554 | 0.438 | 0.7 | <.0001 | 736 | |
| Donor type | ||||||
| Haploidentical | 1.00 | — | — | — | <.0001 | 42 |
| HLA-identical sibling | 0.575 | 0.193 | 1.71 | .3195 | 378 | |
| Well-matched URD | 1.022 | 0.363 | 2.873 | .9677 | 478 | |
| Partially matched URD | 3.105 | 1.097 | 8.794 | .0329 | 149 | |
| CB | 1.545 | 0.548 | 4.356 | .4104 | 298 | |
| Disease | ||||||
| AML | 1.00 | — | — | — | .0029 | 609 |
| ALL | 1.771 | 1.216 | 2.58 | .0029 | 736 | |
| KPS | ||||||
| ≥90% | 1.00 | — | — | — | .0003 | 1164 |
| <90% | 2.141 | 1.419 | 3.231 | .0003 | 181 |
| Outcome . | HR . | 95% CI, lower limit . | 95% CI, upper limit . | P . | Overall P . | n . |
|---|---|---|---|---|---|---|
| KIR cohort and CIBMTR cohort | ||||||
| aGVHD 2-4 | ||||||
| Donor type | ||||||
| Haploidentical | 1.00 | — | — | — | .0001 | 46 |
| HLA-identical sibling | 2.186 | 0.834 | 5.729 | .1117 | 104 | |
| Well-matched URD | 4.093 | 1.626 | 10.302 | .0028 | 119 | |
| Partially matched URD | 4.587 | 1.713 | 12.286 | .0024 | 45 | |
| CB | 4.907 | 2.00 | 12.039 | .0005 | 254 | |
| aGVHD 3-4 | ||||||
| Donor type | ||||||
| Haploidentical | 1.00 | — | — | — | .0062 | 46 |
| HLA-identical sibling | 2.633 | 0.316 | 21.95 | .371 | 104 | |
| Well-matched URD | 10.214 | 1.37 | 76.172 | .0234 | 119 | |
| Partially matched URD | 11.374 | 1.458 | 88.731 | .0204 | 45 | |
| CB | 8.129 | 1.11 | 59.526 | .0391 | 254 | |
| Race | ||||||
| White | 1.00 | — | — | — | .045 | 360 |
| Black | 2.087 | 1.206 | 3.61 | .0086 | 79 | |
| Others | 0.963 | 0.47 | 1.972 | .9183 | 75 | |
| Data missing | 0.834 | 0.33 | 2.109 | .7008 | 54 | |
| Disease | ||||||
| AML | 1.00 | — | — | — | .016 | 272 |
| ALL | 1.75 | 1.11 | 2.76 | .016 | 296 | |
| cGVHD | ||||||
| Donor type | ||||||
| Haploidentical | 1.00 | — | — | — | <.0001 | 46 |
| HLA-identical sibling | 2.932 | 1.079 | 7.966 | .0349 | 521 | |
| Well-matched URD | 4.508 | 1.668 | 12.181 | .003 | 659 | |
| Partially matched URD | 5.108 | 1.862 | 14.01 | .0015 | 212 | |
| CB | 3.362 | 1.233 | 9.166 | .0178 | 408 | |
| Ethnicity | .0004 | |||||
| Hispanic | 1.00 | — | — | — | 568 | |
| Non-Hispanic | 0.657 | 0.53 | 0.814 | .0001 | 1200 | |
| Data missing | 0.627 | 0.377 | 1.041 | .071 | 78 | |
| Race | ||||||
| White | 1.00 | — | — | — | <.0001 | 1340 |
| Black | 2.115 | 1.567 | 2.856 | <.0001 | 145 | |
| Others | 1.633 | 1.21 | 2.204 | .0013 | 159 | |
| Data missing | 0.863 | 0.615 | 1.211 | .3938 | 202 | |
| Relapse | ||||||
| Donor type | ||||||
| Haploidentical | 1.00 | — | — | — | .1447 | 46 |
| HLA-identical sibling | 1.794 | 0.84 | 3.835 | .1313 | 526 | |
| Well-matched URD | 1.519 | 0.712 | 3.241 | .28 | 665 | |
| Partially matched URD | 1.261 | 0.565 | 2.814 | .5706 | 216 | |
| CB | 1.738 | 0.808 | 3.737 | .157 | 412 | |
| Disease | ||||||
| AML | 1.00 | — | — | — | <.0001 | 876 |
| ALL | 0.626 | 0.519 | 0.755 | <.0001 | 989 | |
| TRM | ||||||
| Donor type | ||||||
| Haploidentical | 1.00 | — | — | — | <.0001 | 46 |
| HLA-identical sibling | 0.749 | 0.263 | 2.135 | .5885 | 526 | |
| Well-matched URD | 1.223 | 0.441 | 3.393 | .6995 | 665 | |
| Partially matched URD | 2.93 | 1.047 | 8.2 | .0406 | 216 | |
| CB | 1.743 | 0.629 | 4.831 | .2855 | 412 | |
| Ethnicity | ||||||
| Hispanic | 1.00 | — | — | — | .0223 | 569 |
| Non-Hispanic | 0.658 | 0.483 | 0.897 | .008 | 1215 | |
| Data missing | 0.563 | 0.243 | 1.302 | .1791 | 81 | |
| Disease | ||||||
| AML | 1.00 | — | — | — | .0155 | 876 |
| ALL | 1.465 | 1.075 | 1.995 | .0155 | 989 | |
| KPS | ||||||
| ≥90% | 1.00 | — | — | — | <.0001 | 1606 |
| <90% | 2.039 | 1.44 | 2.885 | <.0001 | 259 | |
| MRD− KIR cohort and MRD− CIBMTR cohort | ||||||
| Donor type | ||||||
| Haploidentical | 1.00 | — | — | — | .0016 | 42 |
| HLA-identical sibling | 2.125 | 0.789 | 5.725 | .1359 | 74 | |
| Well-matched URD | 3.87 | 1.516 | 9.879 | .0047 | 86 | |
| Partially matched URD | 2.826 | 0.925 | 8.64 | .0684 | 27 | |
| CB | 4.485 | 1.812 | 11.099 | .0012 | 177 | |
| Donor type | ||||||
| Haploidentical | 1.00 | — | — | — | .004 | 42 |
| HLA-identical sibling | 1.817 | 0.189 | 17.477 | .6052 | 74 | |
| Well-matched URD | 12.588 | 1.688 | 93.848 | .0135 | 86 | |
| Partially matched URD | 7.675 | 0.856 | 68.855 | .0687 | 27 | |
| CB | 7.345 | 0.993 | 54.355 | .0509 | 177 | |
| Disease | ||||||
| AML | 1.00 | — | — | — | .0213 | 188 |
| ALL | 1.93 | 1.103 | 3.379 | .0213 | 218 | |
| Donor type | ||||||
| Haploidentical | 1.00 | — | — | — | .0002 | 42 |
| HLA-identical sibling | 2.525 | 0.922 | 6.919 | .0716 | 374 | |
| Well-matched URD | 4.224 | 1.556 | 11.469 | .0047 | 471 | |
| Partially matched URD | 4.617 | 1.66 | 12.844 | .0034 | 147 | |
| CB | 3.19 | 1.161 | 8.764 | .0245 | 296 | |
| Ethnicity | .0013 | |||||
| Hispanic | 1.00 | — | — | — | 401 | |
| Non-Hispanic | 0.647 | 0.499 | 0.839 | .001 | 874 | |
| Data missing | 0.455 | 0.229 | 0.905 | .0247 | 55 | |
| Race | ||||||
| White | 1.00 | — | — | — | .0001 | 965 |
| Black | 2.059 | 1.432 | 2.96 | <.0001 | 104 | |
| Others | 1.737 | 1.205 | 2.503 | .0031 | 108 | |
| Data missing | 1.015 | 0.692 | 1.487 | .9405 | 153 | |
| Donor type | ||||||
| Haploidentical | 1.00 | — | — | — | .0604 | 42 |
| HLA-identical sibling | 2.642 | 0.971 | 7.191 | .0572 | 378 | |
| Well-matched URD | 2.219 | 0.816 | 6.033 | .1183 | 478 | |
| Partially matched URD | 1.499 | 0.514 | 4.37 | .4588 | 149 | |
| CB | 2.506 | 0.914 | 6.869 | .0741 | 298 | |
| Disease | ||||||
| AML | 1.00 | — | — | — | <.0001 | 609 |
| ALL | 0.554 | 0.438 | 0.7 | <.0001 | 736 | |
| Donor type | ||||||
| Haploidentical | 1.00 | — | — | — | <.0001 | 42 |
| HLA-identical sibling | 0.575 | 0.193 | 1.71 | .3195 | 378 | |
| Well-matched URD | 1.022 | 0.363 | 2.873 | .9677 | 478 | |
| Partially matched URD | 3.105 | 1.097 | 8.794 | .0329 | 149 | |
| CB | 1.545 | 0.548 | 4.356 | .4104 | 298 | |
| Disease | ||||||
| AML | 1.00 | — | — | — | .0029 | 609 |
| ALL | 1.771 | 1.216 | 2.58 | .0029 | 736 | |
| KPS | ||||||
| ≥90% | 1.00 | — | — | — | .0003 | 1164 |
| <90% | 2.141 | 1.419 | 3.231 | .0003 | 181 |
Shown are data for factors associated with GVHD, relapse, and TRM (in patients with ALL or AML). Bold P-values indicate statistically significant results. KPS, Karnofsky, performance score.