HLA matching in umbilical cord blood allogeneic hematopoietic cell transplantation
| Reference . | Consensus guidelines . |
|---|---|
| Dehn et al20 (2019) | ≥4/6 HLA-A and -B antigen match, HLA-DRB1 high-resolution match, ≥4/8 high-resolution match meeting minimum cryopreserved cell dose for single unit alloHCT of TNC ≥2.5 × 107/kg and CD34+ cells ≥1.5 × 105/kg and double-unit alloHCT TNC ≥1.5 × 107/kg and CD34+ cells ≥1.0 × 105/kg per unit |
| Politikos et al9 (2020) | ≥4/6 HLA-A and -B antigen match, HLA-DRB1 high-resolution match, ≥4/8 high-resolution match meeting minimum cryopreserved cell dose for single-unit alloHCT of TNC ≥3.0 × 107/kg and CD34+ cells ≥2.0 × 105/kg and double-unit alloHCT CD34+ cells ≥1.5 × 105/kg per unit |
| Reference . | Consensus guidelines . |
|---|---|
| Dehn et al20 (2019) | ≥4/6 HLA-A and -B antigen match, HLA-DRB1 high-resolution match, ≥4/8 high-resolution match meeting minimum cryopreserved cell dose for single unit alloHCT of TNC ≥2.5 × 107/kg and CD34+ cells ≥1.5 × 105/kg and double-unit alloHCT TNC ≥1.5 × 107/kg and CD34+ cells ≥1.0 × 105/kg per unit |
| Politikos et al9 (2020) | ≥4/6 HLA-A and -B antigen match, HLA-DRB1 high-resolution match, ≥4/8 high-resolution match meeting minimum cryopreserved cell dose for single-unit alloHCT of TNC ≥3.0 × 107/kg and CD34+ cells ≥2.0 × 105/kg and double-unit alloHCT CD34+ cells ≥1.5 × 105/kg per unit |
TNC, total nucleated cell count.