HLA matching in matched unrelated donor allogeneic hematopoietic cell transplantation
| Reference . | Consensus guidelines . | |||
|---|---|---|---|---|
| Dehn et al20 (2019) | 1. 8/8 match at ARD level for HLA-A, B, C, DRB1 2. Younger donor age 3. Match or permissive HLA-DPB1 TCE 4. Minimize mismatches at HLA-DRB3/4/5 and DQB1 5. Avoid DSA targets including DQA1 and DPA1 | |||
| New research published, since release of guidelines | ||||
| Reference | Population | Study type | Comparison | Key findings |
| Mayor et al4 (2021), ultra-high resolution | N = 5140 10/10 MUD, first alloHCT for ALL, AML, or MDS. Myeloablative or RIC | Observational—multicenter | 12/12 Ultra-high resolution vs ≤11/12 | UHR matching associated with lower risk of acute GVHD II-IV, no associations with survival outcomes |
| Arrieta-Bolaños et al28 (2022), TCE core | N = 5140 10/10 MUD, first alloHCT for ALL, AML, or MDS. Myeloablative or RIC | Observational—multicenter | 10/10 MUD HLA-DPB1 permissive core alleles vs noncore alleles vs nonpermissive | 10/10 MUD HLA-DPB1 TCE3 permissive core associated with reduced risk of acute GVHD II-IV and TRM compared to nonpermissive mismatches |
| Reference . | Consensus guidelines . | |||
|---|---|---|---|---|
| Dehn et al20 (2019) | 1. 8/8 match at ARD level for HLA-A, B, C, DRB1 2. Younger donor age 3. Match or permissive HLA-DPB1 TCE 4. Minimize mismatches at HLA-DRB3/4/5 and DQB1 5. Avoid DSA targets including DQA1 and DPA1 | |||
| New research published, since release of guidelines | ||||
| Reference | Population | Study type | Comparison | Key findings |
| Mayor et al4 (2021), ultra-high resolution | N = 5140 10/10 MUD, first alloHCT for ALL, AML, or MDS. Myeloablative or RIC | Observational—multicenter | 12/12 Ultra-high resolution vs ≤11/12 | UHR matching associated with lower risk of acute GVHD II-IV, no associations with survival outcomes |
| Arrieta-Bolaños et al28 (2022), TCE core | N = 5140 10/10 MUD, first alloHCT for ALL, AML, or MDS. Myeloablative or RIC | Observational—multicenter | 10/10 MUD HLA-DPB1 permissive core alleles vs noncore alleles vs nonpermissive | 10/10 MUD HLA-DPB1 TCE3 permissive core associated with reduced risk of acute GVHD II-IV and TRM compared to nonpermissive mismatches |
ALL, acute lymphoblastic leukemia; AML, acute myeloid leukemia; DSA, donor-specific anti-HLA antibodies; MDS, myelodysplastic syndromes; RIC, reduced intensity conditioning; TRM, transplant-related mortality; UHR, ultrahigh resolution; 8/8, high-resolution match at HLA-A, B, C, and DRB1; 10/10, high-resolution match at HLA-A, B, C, DRB1, and DQB1; 12/12, HLA match at HLA-A, B, C, DRB1, DQB1, and DPB1.