Table 1. Suggested diagnostic evaluation... | American Society of Hematology

Table 1.

Suggested diagnostic evaluation for CAIHA

Suggested adult CAIHA workup
Hematologic testing	Required for pediatrics
CBC^a	Yes
Peripheral smear^a	Yes
DAT^a	Yes
Hemolysis screen^a	Yes
LDH, haptoglobin, bilirubin, reticulocyte count, urinalysis
Cold agglutinin titer^a
Thermal amplitude
C3 and C4 levels	Based on clinical scenario
Immunoglobulin quanitification	Based on clinical scenario
Serum protein electrophoresis + immunofixation^a
Bone marrow studies^a
Histologic examination
Flow cytometry
Infectious workup
Mycoplasma	Recommended
Viral testing: HIV, HBV. HCV, EBV	Recommended
Autoimmune screening
Antinuclear antibodies^a	Based on clinical scenario
dsDNA	Based on clinical scenario
Malignancy screening^a
CT chest abdomen and pelvis

Suggested adult CAIHA workup
Hematologic testing	Required for pediatrics
CBC^a	Yes
Peripheral smear^a	Yes
DAT^a	Yes
Hemolysis screen^a	Yes
LDH, haptoglobin, bilirubin, reticulocyte count, urinalysis
Cold agglutinin titer^a
Thermal amplitude
C3 and C4 levels	Based on clinical scenario
Immunoglobulin quanitification	Based on clinical scenario
Serum protein electrophoresis + immunofixation^a
Bone marrow studies^a
Histologic examination
Flow cytometry
Infectious workup
Mycoplasma	Recommended
Viral testing: HIV, HBV. HCV, EBV	Recommended
Autoimmune screening
Antinuclear antibodies^a	Based on clinical scenario
dsDNA	Based on clinical scenario
Malignancy screening^a
CT chest abdomen and pelvis

Minimum required for diagnosis of CAD vs CAS; other studies based on clinical scenario.

EBV, Epstein-Barr virus; HBV, hepatitis B virus; HCV, hepatitis C virus.