Most common adverse events with new agents
| Drug . | AEs . | SAEs . | Drug discontinuation . |
|---|---|---|---|
| Lenalidomide | Neutropenia, diarrhea, constipation, cough, fatigue, pyrexia, leukopenia, URI, anemia | Pneumonia, febrile neutropenia, neutropenia, pulmonary embolism, sepsis, pyrexia | 14 due to AEs (neutropenia most common reason) |
| Copanlisib | Hyperglycemia, diarrhea, hypertension (transient), neutropenia | Pneumonia, pyrexia, hypergyclemia, pneumonitis | 38 patients due to AEs (pneumonitis and neutropenia most common) |
| Tazemetostat | Nausea, diarrhea, alopecia, cough, asthenia, fatigue, URI, bronchitis | Neutropenia, pancytopenia, transient global amnesia, arrhythmia, myelodysplastic syndrome | 8 patients due to AEs no common AE noted |
| Axi-cel | CRS, pyrexia, hypotension, headache, fatigue, nausea, anemia, ICANS, neutropenia, sinus tachycardia, tremor, chills, vomiting, diarrhea, anorexia, hypoxia, confused state, cough, encephalopathy, dizziness | Pyrexia, encephalopathy, pneumonia, confused state, hypotension, hypoxia, somnolence, febrile neutropenia aphasia, embolism, headache, neutropenia, urinary tract infection, agitation, aspartate aminotransferase increased | N/A |
| Tisa-cel | CRS, neutropenia, anemia, leukopenia, thrombocytopenia, neutropenia, febrile neutropenia, ICANS, headache, dizziness, diarrhea, infections, constipation, nausea, vomiting | Neutropenia, leukopenia, anemia, febrile neutropenia, thrombocytopenia, GI disorders | N/A |
| Drug . | AEs . | SAEs . | Drug discontinuation . |
|---|---|---|---|
| Lenalidomide | Neutropenia, diarrhea, constipation, cough, fatigue, pyrexia, leukopenia, URI, anemia | Pneumonia, febrile neutropenia, neutropenia, pulmonary embolism, sepsis, pyrexia | 14 due to AEs (neutropenia most common reason) |
| Copanlisib | Hyperglycemia, diarrhea, hypertension (transient), neutropenia | Pneumonia, pyrexia, hypergyclemia, pneumonitis | 38 patients due to AEs (pneumonitis and neutropenia most common) |
| Tazemetostat | Nausea, diarrhea, alopecia, cough, asthenia, fatigue, URI, bronchitis | Neutropenia, pancytopenia, transient global amnesia, arrhythmia, myelodysplastic syndrome | 8 patients due to AEs no common AE noted |
| Axi-cel | CRS, pyrexia, hypotension, headache, fatigue, nausea, anemia, ICANS, neutropenia, sinus tachycardia, tremor, chills, vomiting, diarrhea, anorexia, hypoxia, confused state, cough, encephalopathy, dizziness | Pyrexia, encephalopathy, pneumonia, confused state, hypotension, hypoxia, somnolence, febrile neutropenia aphasia, embolism, headache, neutropenia, urinary tract infection, agitation, aspartate aminotransferase increased | N/A |
| Tisa-cel | CRS, neutropenia, anemia, leukopenia, thrombocytopenia, neutropenia, febrile neutropenia, ICANS, headache, dizziness, diarrhea, infections, constipation, nausea, vomiting | Neutropenia, leukopenia, anemia, febrile neutropenia, thrombocytopenia, GI disorders | N/A |
GI, gastrointestinal; N/A, not available; SAE, serious adverse event; URI, upper respiratory infection.