Thromboprophylaxis to prevent first-time VTE recommendations in the antepartum and postpartum states for given thrombophilias with or without family history of thrombosis in ≥1 first-degree relative if applicable29
| Thrombophilia . | Family history of thrombosis . | Antepartum . | Postpartum . |
|---|---|---|---|
| Protein C or S deficiency | Yes | Not recommended | Recommended |
| No | Not recommended | Not recommended | |
| Antithrombin deficiency | Yes | Recommended | Recommended (strong) |
| No | Not recommended | Not recommended | |
| Factor V Leiden (FVL), heterozygous | NA | Not recommended | Not recommended |
| Prothrombin gene mutation (PGM), heterozygous | NA | Not recommended | Not recommended |
| PGM (homozygous) | NA | Not recommended | Recommended |
| FVL (homozygous), combined mutation | NA | Recommended | Recommended |
| Thrombophilia . | Family history of thrombosis . | Antepartum . | Postpartum . |
|---|---|---|---|
| Protein C or S deficiency | Yes | Not recommended | Recommended |
| No | Not recommended | Not recommended | |
| Antithrombin deficiency | Yes | Recommended | Recommended (strong) |
| No | Not recommended | Not recommended | |
| Factor V Leiden (FVL), heterozygous | NA | Not recommended | Not recommended |
| Prothrombin gene mutation (PGM), heterozygous | NA | Not recommended | Not recommended |
| PGM (homozygous) | NA | Not recommended | Recommended |
| FVL (homozygous), combined mutation | NA | Recommended | Recommended |
NA, not applicable.