A summary of current knowledge regarding the molecular mechanisms of subsequent neoplasms
| Reference . | Type of subsequent neoplasm . | Genes/genetic variants/molecular pathways associated with subsequent neoplasms . |
|---|---|---|
| Subsequent breast cancer | ||
| Wang et al17 | Radiation-related subsequent breast cancer | Pathogenic/likely pathogenic mutations in 60 cancer predisposition genes |
| Wang et al17 | Subsequent breast cancer without exposure to radiation | Pathogenic/likely pathogenic mutations in 60 cancer predisposition genes |
| Qin et al18 | Radiation-related subsequent breast cancer or breast cancer after exposure to higher doses of anthracyclines | Mutations in homologous recombination genes |
| Morton et al19 | Radiation-related breast cancer | rs4342822, nearest gene PROX1 |
| Best et al20 | SNs (primarily radiation-related breast cancer) | Two variants at chromosome 6q21. The variants compose a risk locus associated with decreased basal expression of PRDM1 and impaired induction of the PRDM1 protein after radiation exposure. |
| Opstal-van Winden et al26 | Radiation-related breast cancer | SNP in the PVT1 oncogene |
| Subsequent sarcoma | ||
| Wang et al17 | Radiation-related subsequent sarcoma | Pathogenic/likely pathogenic mutations in 60 cancer predisposition genes |
| Qin et al18 | Subsequent sarcoma after exposure to high doses of alkylating agents | Mutations in homologous recombination genes |
| Subsequent thyroid cancer | ||
| Qin et al18 | Radiation-related thyroid cancer | Nucleotide excision repair gene mutations |
| Gramatges et al21 | Radiation-related thyroid cancer | Reduced telomere content |
| Richard et al22 | Radiation-related thyroid cancer | The minor allele at protection of telomeres-1 (POT1) rs58722976 was associated with increased risk for subsequent thyroid cancer. |
| Man et al23 | Radiation-related thyroid cancer | Childhood cancer survivors with subsequent thyroid cancer had shorter median lymphocyte telomere length than controls in leukocyte subsets (natural killer cell, naive T cell). |
| Subsequent basal cell carcinoma | ||
| Wang et al17 | Subsequent BBC without exposure to radiation | Pathogenic/likely pathogenic mutations in 60 cancer predisposition genes |
| Sapkota et al24 | Subsequent BBC | Risk locus in HTR2A that was specific to survivors with reduced clinical risk |
| Wang et al29 | Radiation-related brain tumors | SNPs (rs15869 [BRCA2], rs1805389 [LIG4], rs8079544 [TP53], rs25489 [XRCC1], rs1673041 [POLD1], and rs11615 [ERCC1]) |
| Multiple subsequent neoplasms | ||
| Wang et al17 | Multiple subsequent neoplasms without exposure to radiation | Pathogenic/likely pathogenic mutations in 60 cancer predisposition genes |
| Reference . | Type of subsequent neoplasm . | Genes/genetic variants/molecular pathways associated with subsequent neoplasms . |
|---|---|---|
| Subsequent breast cancer | ||
| Wang et al17 | Radiation-related subsequent breast cancer | Pathogenic/likely pathogenic mutations in 60 cancer predisposition genes |
| Wang et al17 | Subsequent breast cancer without exposure to radiation | Pathogenic/likely pathogenic mutations in 60 cancer predisposition genes |
| Qin et al18 | Radiation-related subsequent breast cancer or breast cancer after exposure to higher doses of anthracyclines | Mutations in homologous recombination genes |
| Morton et al19 | Radiation-related breast cancer | rs4342822, nearest gene PROX1 |
| Best et al20 | SNs (primarily radiation-related breast cancer) | Two variants at chromosome 6q21. The variants compose a risk locus associated with decreased basal expression of PRDM1 and impaired induction of the PRDM1 protein after radiation exposure. |
| Opstal-van Winden et al26 | Radiation-related breast cancer | SNP in the PVT1 oncogene |
| Subsequent sarcoma | ||
| Wang et al17 | Radiation-related subsequent sarcoma | Pathogenic/likely pathogenic mutations in 60 cancer predisposition genes |
| Qin et al18 | Subsequent sarcoma after exposure to high doses of alkylating agents | Mutations in homologous recombination genes |
| Subsequent thyroid cancer | ||
| Qin et al18 | Radiation-related thyroid cancer | Nucleotide excision repair gene mutations |
| Gramatges et al21 | Radiation-related thyroid cancer | Reduced telomere content |
| Richard et al22 | Radiation-related thyroid cancer | The minor allele at protection of telomeres-1 (POT1) rs58722976 was associated with increased risk for subsequent thyroid cancer. |
| Man et al23 | Radiation-related thyroid cancer | Childhood cancer survivors with subsequent thyroid cancer had shorter median lymphocyte telomere length than controls in leukocyte subsets (natural killer cell, naive T cell). |
| Subsequent basal cell carcinoma | ||
| Wang et al17 | Subsequent BBC without exposure to radiation | Pathogenic/likely pathogenic mutations in 60 cancer predisposition genes |
| Sapkota et al24 | Subsequent BBC | Risk locus in HTR2A that was specific to survivors with reduced clinical risk |
| Wang et al29 | Radiation-related brain tumors | SNPs (rs15869 [BRCA2], rs1805389 [LIG4], rs8079544 [TP53], rs25489 [XRCC1], rs1673041 [POLD1], and rs11615 [ERCC1]) |
| Multiple subsequent neoplasms | ||
| Wang et al17 | Multiple subsequent neoplasms without exposure to radiation | Pathogenic/likely pathogenic mutations in 60 cancer predisposition genes |