Multiple myeloma diagnostic criteria
| Clonal bone marrow plasma cells | ≥10% |
| OR | |
| Biopsy-proven plasmacytoma | |
| AND | |
| “CRAB” | Hypercalcemia: Serum calcium >11 mg/dL or >1 mg/dL above ULN |
| Renal insufficiency: Serum creatinine >2 mg/dL or CrCl <40 mL/min | |
| Anemia: Hemoglobin <10 g/dL or >2 g/dL below LLN | |
| Bone lesions: ≥1 osteolytic lesion (on WBLDCT or PET scan) | |
| OR | |
| “SLiM” criteria | ≥60% clonal bone marrow plasma cells |
| Involved to uninvolved FLC ratio ≥100 and involved FLC ≥10 mg/dL | |
| >1 focal lesion on MRI ≥5 mm in size |
| Clonal bone marrow plasma cells | ≥10% |
| OR | |
| Biopsy-proven plasmacytoma | |
| AND | |
| “CRAB” | Hypercalcemia: Serum calcium >11 mg/dL or >1 mg/dL above ULN |
| Renal insufficiency: Serum creatinine >2 mg/dL or CrCl <40 mL/min | |
| Anemia: Hemoglobin <10 g/dL or >2 g/dL below LLN | |
| Bone lesions: ≥1 osteolytic lesion (on WBLDCT or PET scan) | |
| OR | |
| “SLiM” criteria | ≥60% clonal bone marrow plasma cells |
| Involved to uninvolved FLC ratio ≥100 and involved FLC ≥10 mg/dL | |
| >1 focal lesion on MRI ≥5 mm in size |
FLC, free light chain; MRI, magnetic resonance imaging; PET, positron emission topography; WBLDCT, whole-body low-dose computed tomography.