Diagnostic criteria for smoldering multiple myeloma according to International Myeloma Working Group 2014 criteria2
| Smoldering multiple myeloma diagnosis . |
|---|
| Bone marrow clonal plasma cells 10%-60% |
| M-protein in serum ≥30 g/L or urinary M-protein ≥0.5 g per 24 hours |
| No evidence of other B-cell proliferative disorder |
| No myeloma-related organ or tissue impairment or bone lesions |
| Myeloma-defining events |
| Evidence of end-organ or tissue impairment |
| • Hypercalcemia |
| • Renal insufficiency |
| • Anemia |
| • Osteolytic bone lesions |
| Biomarkers of malignancy |
| • Clonal bone marrow plasma cell percentage ≥60% |
| • Involved: uninvolved serum free light chain ratio ≥100 |
| • >1 focal lesion on MRI studies |
| Smoldering multiple myeloma diagnosis . |
|---|
| Bone marrow clonal plasma cells 10%-60% |
| M-protein in serum ≥30 g/L or urinary M-protein ≥0.5 g per 24 hours |
| No evidence of other B-cell proliferative disorder |
| No myeloma-related organ or tissue impairment or bone lesions |
| Myeloma-defining events |
| Evidence of end-organ or tissue impairment |
| • Hypercalcemia |
| • Renal insufficiency |
| • Anemia |
| • Osteolytic bone lesions |
| Biomarkers of malignancy |
| • Clonal bone marrow plasma cell percentage ≥60% |
| • Involved: uninvolved serum free light chain ratio ≥100 |
| • >1 focal lesion on MRI studies |