Perinatal outcomes in women with SCD
| Reference, type of study, duration of study, and intervention . | Number of SCD pregnancies . | Outcome (%) . | Number of perinatal deaths . | Number of total births . | Perinatal mortality rate (per 1000 total births) . | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| Intrauterine growth restriction . | Preterm birth . | Low birth weight . | Intrauterine fetal deaths/stillbirths . | Perinatal deaths . | Neonatal deaths . | |||||
| Studies conducted in low-middle-income countries in descending order by year of publication | ||||||||||
| Vodouhe et al18 2022 (Benin) Retrospective case-control study Duration: 4 years 7 months Intervention: None stated | 119 | Not stated | 78.1 | 54.7 | 17.6 | Not stated | 8.4 | 21 | 116 | 181.0 |
| Swarray-Deen et al12 2022 (Accra, Ghana) Prospective study Duration: 3 years 7 months Intervention: Multidisciplinary care strategy | 342 | Not stated | 23.7 | Not stated | 3.2 | 2.7 | 0 | 8 | 332 | 24.0 |
| Olugbenga19 2022 (Southwest Nigeria) Prospective cohort study Duration: 3 years 2 months Intervention: None stated | 49 | 12.2 | 12.2 | 12.2 | 4.1 | Not stated | 0 | 2 | 49 | 37.0 |
| Dangbemey et al20 2020 (Cotonou, Benin) Retrospective study Duration: 11 years Intervention: None stated | 384 | 0.8 | 60.0 | Not stated | 9.1 | 9.0 | Not stated | 31 | 383 | 80.7 |
| Tsiba et al21 2020 (Congo) Retrospective case-control study Duration: 2 years Intervention: None stated | 65 | Not stated | 75.4 | 52.3 | Not stated | Not stated | 21.5 | 14 | 65 | 215.4 |
| Modi et al22 2020 (India) Retrospective case-control study Duration: 1 year Intervention: None stated | 43 | 23.3 | 13.9 | 46.5 | 4.7 | 4.7 | 0 | 2 | 43 | 46.5 |
| Zamane et al23 2019 (Ougadougou, Burkina Faso) Retrospective cross-sectional study Duration: 2 years Intervention: Prophylactic blood transfusion | 168 | Not stated | 23.2 | 16.1 | 6.0 | 6.0 | 8.2 | 13 | Not stated | Not defined |
| Patel et al24 2019 (eastern India) Retrospective descriptive study Duration: 6 months Intervention: None stated | 634 | Not stated | 9.6 | Not stated (only mentioned the babies had lower mean birthweight) | 9.0 | Not stated | 4.9 | 57 | 525 | 108.6 |
| Babah et al25 2019 (Lagos, Nigeria) Prospective case-control study Duration: 1 year 3 months Intervention: Multidisciplinary care strategy | 50 | 16.0 | 28.0 | 38.0 | 2.0 | 2.0 | Not stated | 1 | 50 | 20.0 |
| Diallo et al26 2019 (Dakar, Senegal) Retrospective study Duration: 4 years Intervention: None stated | 24 | 54.2 | 30.8 | Not stated | 35.6 | Not stated | Not stated | 6 | 23 | 260.9 |
| Nwafor et al27 2019 (Abakaliki, Nigeria) Retrospective case-control study Duration: 7 years Intervention: None stated | 164 | Not stated | 30.6 | 25.4 | 15.8. | Not stated | 3.7 | 31 | 160 | 193.8 |
| Oppong et al9 2018 and Asare et al5 2019 (Accra, Ghana) Prospective case-control study Duration: 1 year 8 months Intervention: Multidisciplinary care strategy | 149 | 6.3 | 37.9 | 25.2 | 7.4 | 2.2 | 0 | 11 | Not stated | Not defined |
| Asare et al4 2018 (Accra, Ghana) Retrospective and prospective cohort study Duration: 7 years Intervention: None stated | 43 | Not stated | Not stated | Not stated | 40.0 | 6.1 | 0 | Not stated | Not stated | 60.8 |
| Faye et al28 2017 (Senegal) Prospective cohort study Duration: 15 years Intervention: Blood transfusion (chronic, partial exchange, and simple top-up) | 70 | Not stated | 11.8 | Not stated | Not stated | Not stated | Not stated | Not stated | Not stated | Not defined |
| Gaddikeri et al29 2017 (India) Hospital-based prospective (case control) study Duration: 1 year 9 months Intervention: None stated | 12 | 50.0 | 25.0 | 84.6 | 8.3 | Not stated | 8.3 | Not stated | Not stated | 167.0 |
| Desai et al30 2017 (India) Retrospective cohort study Duration: 4 years 6 months Intervention: None stated | 131 delivery admissions | 2.3 | 45.0 | 70.2 | 9.9 | Not stated | Not stated | 13 | 131 | 99.2 |
| Asare et al8 2017 (Accra, Ghana) Prospective cohort study Duration: 1 year 1 month Intervention: Multidisciplinary care strategy | 90 | Not stated | Not stated | Not stated | 0 | 2.2 | 0 | 2 | 90 | 27.4 |
| Studies conducted in upper-middle-income countries in descending order by year of publication | ||||||||||
| Sousa et al31 2020 (Sao Paulo, Brazil) Retrospective descriptive study Duration: 10 years Intervention: Red blood cell transfusion | 55 | Not stated | 34.4 | Not stated | 3.6 | 2 | 3.6 | 2 | 31 | Not defined |
| Silva et al32 2018 (Brazil) Retrospective cohort study Duration: 8 months Intervention: None stated | 89 | Not stated | 30.3 | 39.3 | 15.0 | Not stated | Not stated | 11 | Not stated | Not defined |
| Studies conducted in high-income countries in descending order by year of publication | ||||||||||
| Della-Moretti et al33 2021 (Ohio, USA) Retrospective study Duration: 2 years Intervention: None stated | 59 | Not stated | 50.0 | 36.0 | Not stated | Not stated | 2.0 | Not stated | Not stated | Not defined |
| Cardoso et al34 2019 (United Kingdom) Retrospective descriptive study Duration: 11 years Intervention: Multidisciplinary care strategy | 16 | Not stated | 87.5 | 37.5 pregnancies | Not stated | 0 | 0 | 0 | 0 | 0 |
| Haseeb et al35 2019 (Saudi Arabia) Retrospective study Duration: 11 years Intervention: None stated | 302 | 19.2 | 19.8 | Not stated (only mentioned the babies had lower mean birthweight) | 3.3 | Not stated | 1.6 | 10 | 302 | 33.1 |
| Vianello et al36 2018 (Italy) Retrospective cross-sectional study Duration: 9 years 5 months Intervention: Erythrocytapheresis at 10.7 ± 5.2 weeks gestation and enoxaparin | 46 | Not stated | 21.7 | 78.3 | 6.5 | Not stated | Not stated | 3 | 26 | 115.4 |
| Ribeil et al37 2018 (France) Retrospective cohort study Duration: 10 years Intervention: Prophylactic blood transfusion and prophylactic oxygen therapy at home | 191 | 4.3 | 34.0 | 7.9 | 1.1 | 2.1 | Not stated | 4 | 188 | 21.3 |
| Sharif et al38 2018 (UK) Retrospective cohort study Duration: 11 years Intervention: On-demand blood transfusion | 38 | 10.5 | 21.0 | Not stated | 2.6 | 2.6 | Not stated | 1 | Not stated | Not defined |
| Chang et al39 2018 (USA) Retrospective cohort study Duration: 12 years Intervention: None stated | 428 | 27.5 | 28.8 | 0 | Not stated | Not stated | 1.7 | Not stated | Not stated | Not defined |
| Koumoutsea et al40 2018 (London, UK) Retrospective study Duration: 7 years Intervention: Exchange blood transfusion | 50 | 22.0 | 38.0 | Not stated | 0 | Not stated | Not stated | 0 | 25 | 0 |
| Reference, type of study, duration of study, and intervention . | Number of SCD pregnancies . | Outcome (%) . | Number of perinatal deaths . | Number of total births . | Perinatal mortality rate (per 1000 total births) . | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| Intrauterine growth restriction . | Preterm birth . | Low birth weight . | Intrauterine fetal deaths/stillbirths . | Perinatal deaths . | Neonatal deaths . | |||||
| Studies conducted in low-middle-income countries in descending order by year of publication | ||||||||||
| Vodouhe et al18 2022 (Benin) Retrospective case-control study Duration: 4 years 7 months Intervention: None stated | 119 | Not stated | 78.1 | 54.7 | 17.6 | Not stated | 8.4 | 21 | 116 | 181.0 |
| Swarray-Deen et al12 2022 (Accra, Ghana) Prospective study Duration: 3 years 7 months Intervention: Multidisciplinary care strategy | 342 | Not stated | 23.7 | Not stated | 3.2 | 2.7 | 0 | 8 | 332 | 24.0 |
| Olugbenga19 2022 (Southwest Nigeria) Prospective cohort study Duration: 3 years 2 months Intervention: None stated | 49 | 12.2 | 12.2 | 12.2 | 4.1 | Not stated | 0 | 2 | 49 | 37.0 |
| Dangbemey et al20 2020 (Cotonou, Benin) Retrospective study Duration: 11 years Intervention: None stated | 384 | 0.8 | 60.0 | Not stated | 9.1 | 9.0 | Not stated | 31 | 383 | 80.7 |
| Tsiba et al21 2020 (Congo) Retrospective case-control study Duration: 2 years Intervention: None stated | 65 | Not stated | 75.4 | 52.3 | Not stated | Not stated | 21.5 | 14 | 65 | 215.4 |
| Modi et al22 2020 (India) Retrospective case-control study Duration: 1 year Intervention: None stated | 43 | 23.3 | 13.9 | 46.5 | 4.7 | 4.7 | 0 | 2 | 43 | 46.5 |
| Zamane et al23 2019 (Ougadougou, Burkina Faso) Retrospective cross-sectional study Duration: 2 years Intervention: Prophylactic blood transfusion | 168 | Not stated | 23.2 | 16.1 | 6.0 | 6.0 | 8.2 | 13 | Not stated | Not defined |
| Patel et al24 2019 (eastern India) Retrospective descriptive study Duration: 6 months Intervention: None stated | 634 | Not stated | 9.6 | Not stated (only mentioned the babies had lower mean birthweight) | 9.0 | Not stated | 4.9 | 57 | 525 | 108.6 |
| Babah et al25 2019 (Lagos, Nigeria) Prospective case-control study Duration: 1 year 3 months Intervention: Multidisciplinary care strategy | 50 | 16.0 | 28.0 | 38.0 | 2.0 | 2.0 | Not stated | 1 | 50 | 20.0 |
| Diallo et al26 2019 (Dakar, Senegal) Retrospective study Duration: 4 years Intervention: None stated | 24 | 54.2 | 30.8 | Not stated | 35.6 | Not stated | Not stated | 6 | 23 | 260.9 |
| Nwafor et al27 2019 (Abakaliki, Nigeria) Retrospective case-control study Duration: 7 years Intervention: None stated | 164 | Not stated | 30.6 | 25.4 | 15.8. | Not stated | 3.7 | 31 | 160 | 193.8 |
| Oppong et al9 2018 and Asare et al5 2019 (Accra, Ghana) Prospective case-control study Duration: 1 year 8 months Intervention: Multidisciplinary care strategy | 149 | 6.3 | 37.9 | 25.2 | 7.4 | 2.2 | 0 | 11 | Not stated | Not defined |
| Asare et al4 2018 (Accra, Ghana) Retrospective and prospective cohort study Duration: 7 years Intervention: None stated | 43 | Not stated | Not stated | Not stated | 40.0 | 6.1 | 0 | Not stated | Not stated | 60.8 |
| Faye et al28 2017 (Senegal) Prospective cohort study Duration: 15 years Intervention: Blood transfusion (chronic, partial exchange, and simple top-up) | 70 | Not stated | 11.8 | Not stated | Not stated | Not stated | Not stated | Not stated | Not stated | Not defined |
| Gaddikeri et al29 2017 (India) Hospital-based prospective (case control) study Duration: 1 year 9 months Intervention: None stated | 12 | 50.0 | 25.0 | 84.6 | 8.3 | Not stated | 8.3 | Not stated | Not stated | 167.0 |
| Desai et al30 2017 (India) Retrospective cohort study Duration: 4 years 6 months Intervention: None stated | 131 delivery admissions | 2.3 | 45.0 | 70.2 | 9.9 | Not stated | Not stated | 13 | 131 | 99.2 |
| Asare et al8 2017 (Accra, Ghana) Prospective cohort study Duration: 1 year 1 month Intervention: Multidisciplinary care strategy | 90 | Not stated | Not stated | Not stated | 0 | 2.2 | 0 | 2 | 90 | 27.4 |
| Studies conducted in upper-middle-income countries in descending order by year of publication | ||||||||||
| Sousa et al31 2020 (Sao Paulo, Brazil) Retrospective descriptive study Duration: 10 years Intervention: Red blood cell transfusion | 55 | Not stated | 34.4 | Not stated | 3.6 | 2 | 3.6 | 2 | 31 | Not defined |
| Silva et al32 2018 (Brazil) Retrospective cohort study Duration: 8 months Intervention: None stated | 89 | Not stated | 30.3 | 39.3 | 15.0 | Not stated | Not stated | 11 | Not stated | Not defined |
| Studies conducted in high-income countries in descending order by year of publication | ||||||||||
| Della-Moretti et al33 2021 (Ohio, USA) Retrospective study Duration: 2 years Intervention: None stated | 59 | Not stated | 50.0 | 36.0 | Not stated | Not stated | 2.0 | Not stated | Not stated | Not defined |
| Cardoso et al34 2019 (United Kingdom) Retrospective descriptive study Duration: 11 years Intervention: Multidisciplinary care strategy | 16 | Not stated | 87.5 | 37.5 pregnancies | Not stated | 0 | 0 | 0 | 0 | 0 |
| Haseeb et al35 2019 (Saudi Arabia) Retrospective study Duration: 11 years Intervention: None stated | 302 | 19.2 | 19.8 | Not stated (only mentioned the babies had lower mean birthweight) | 3.3 | Not stated | 1.6 | 10 | 302 | 33.1 |
| Vianello et al36 2018 (Italy) Retrospective cross-sectional study Duration: 9 years 5 months Intervention: Erythrocytapheresis at 10.7 ± 5.2 weeks gestation and enoxaparin | 46 | Not stated | 21.7 | 78.3 | 6.5 | Not stated | Not stated | 3 | 26 | 115.4 |
| Ribeil et al37 2018 (France) Retrospective cohort study Duration: 10 years Intervention: Prophylactic blood transfusion and prophylactic oxygen therapy at home | 191 | 4.3 | 34.0 | 7.9 | 1.1 | 2.1 | Not stated | 4 | 188 | 21.3 |
| Sharif et al38 2018 (UK) Retrospective cohort study Duration: 11 years Intervention: On-demand blood transfusion | 38 | 10.5 | 21.0 | Not stated | 2.6 | 2.6 | Not stated | 1 | Not stated | Not defined |
| Chang et al39 2018 (USA) Retrospective cohort study Duration: 12 years Intervention: None stated | 428 | 27.5 | 28.8 | 0 | Not stated | Not stated | 1.7 | Not stated | Not stated | Not defined |
| Koumoutsea et al40 2018 (London, UK) Retrospective study Duration: 7 years Intervention: Exchange blood transfusion | 50 | 22.0 | 38.0 | Not stated | 0 | Not stated | Not stated | 0 | 25 | 0 |