Main classes of mutations in follicular lymphoma
| Mutational class . | Frequency . | Mutated/altered genes . |
|---|---|---|
| Epigenetic modifiers | >90% | KMT2D, CREBBP, EZH2, EP300, HIST1H1B-E |
| Immune regulation | ~28%-40%; 6% | TNFRSF14, CTSS |
| mTOR signaling | >30% | RRAGC, ATP6V1B2, ATP6AP1, SESTRIN1 |
| Cell cycle regulators | ~10%-15% | CDKN2A/B, CCND3, MYC, TP53 |
| Jak/STAT signaling | ~20% | STAT6, SOCS1 |
| NFκB signaling | >15% | CARD11, TNFAIP3, CD79A/B, MYD88 |
| Mutational class . | Frequency . | Mutated/altered genes . |
|---|---|---|
| Epigenetic modifiers | >90% | KMT2D, CREBBP, EZH2, EP300, HIST1H1B-E |
| Immune regulation | ~28%-40%; 6% | TNFRSF14, CTSS |
| mTOR signaling | >30% | RRAGC, ATP6V1B2, ATP6AP1, SESTRIN1 |
| Cell cycle regulators | ~10%-15% | CDKN2A/B, CCND3, MYC, TP53 |
| Jak/STAT signaling | ~20% | STAT6, SOCS1 |
| NFκB signaling | >15% | CARD11, TNFAIP3, CD79A/B, MYD88 |