Studies examining the impact of aging on plasma VWF levels in type 1 VWD cohorts
| Study . | n . | Baseline plasma VWF levels . | Age at diagnosis (range), y . | Duration of follow-up, mean (range), y . | Baseline plasma VWF levels, mean, IU/dL . | Change in plasma VWF levels, IU/dL/y . | Last plasma VWF level >50 IU/dL, n (%) . | |
|---|---|---|---|---|---|---|---|---|
| <30 IU/dL . | 30-50 IU/dL . | |||||||
| Abou-Ismail et al34 | 126 | 46 | 80 | Mean 27.7 ± 16.2 (SD) | 10.5 (5-20) | VWF:Ag 40.6 VWF:RCo 36.7 | VWF:Ag 2.4 VWF:RCo 1.4 | 35/126 (27.8) |
| Borghi et al26 | 195 | 52 | Median 28.7 (0.4-74.5) | 6.6 (0.4-24.7) | VWF:Ag 23 VWF:RCo 18 | VWF:Ag 0.62 VWF:RCo 0.47 | 117/195 (60) | |
| 143 | VWF:Ag 47 VWF:RCo 43 | |||||||
| Lavin et al.25 | 64 | 0 | 64 | Mean 36.4 (15-66) | 8.5 (5-17) | VWF:Ag 47.8 VWF:RCo 39.4 | VWF:Ag 1.9 VWF:RCo 1.5 | 29/64 (45) |
| Rydz et al33 | 31 | 8 | 23 | Mean 30 (16-60) | 11 (5-26) | VWF:Ag 44 VWF:RCo 34 | VWF:Ag 3.0 VWF:RCo 2.0 | 18/31 (58) |
| Sanders et al24 | 40 | 40 | Only age at study inclusion reported | VWF:Ag 0.35 VWF:RCo 0.95 | ||||
| Study . | n . | Baseline plasma VWF levels . | Age at diagnosis (range), y . | Duration of follow-up, mean (range), y . | Baseline plasma VWF levels, mean, IU/dL . | Change in plasma VWF levels, IU/dL/y . | Last plasma VWF level >50 IU/dL, n (%) . | |
|---|---|---|---|---|---|---|---|---|
| <30 IU/dL . | 30-50 IU/dL . | |||||||
| Abou-Ismail et al34 | 126 | 46 | 80 | Mean 27.7 ± 16.2 (SD) | 10.5 (5-20) | VWF:Ag 40.6 VWF:RCo 36.7 | VWF:Ag 2.4 VWF:RCo 1.4 | 35/126 (27.8) |
| Borghi et al26 | 195 | 52 | Median 28.7 (0.4-74.5) | 6.6 (0.4-24.7) | VWF:Ag 23 VWF:RCo 18 | VWF:Ag 0.62 VWF:RCo 0.47 | 117/195 (60) | |
| 143 | VWF:Ag 47 VWF:RCo 43 | |||||||
| Lavin et al.25 | 64 | 0 | 64 | Mean 36.4 (15-66) | 8.5 (5-17) | VWF:Ag 47.8 VWF:RCo 39.4 | VWF:Ag 1.9 VWF:RCo 1.5 | 29/64 (45) |
| Rydz et al33 | 31 | 8 | 23 | Mean 30 (16-60) | 11 (5-26) | VWF:Ag 44 VWF:RCo 34 | VWF:Ag 3.0 VWF:RCo 2.0 | 18/31 (58) |
| Sanders et al24 | 40 | 40 | Only age at study inclusion reported | VWF:Ag 0.35 VWF:RCo 0.95 | ||||