Risk factors for myeloid malignancy development in patients with sickle cell disease
| Risk factor . | Reference . |
|---|---|
| Erythropoietic stress | Ghannam et al21 |
| Inflammation | Platt36 |
| Hypoxia and acidosis | Muz et al37 |
| Transfusion-related immunomodulation | Vamvakas and Blajchman38 |
| Compromised apoptosis | Ribeil39 |
| Endothelial damage | Hebbel et al40 |
| Increased age | Adelman and Figueroa41 |
| Clonal hematopoiesis | Pincez et al25 |
| Risk factor . | Reference . |
|---|---|
| Erythropoietic stress | Ghannam et al21 |
| Inflammation | Platt36 |
| Hypoxia and acidosis | Muz et al37 |
| Transfusion-related immunomodulation | Vamvakas and Blajchman38 |
| Compromised apoptosis | Ribeil39 |
| Endothelial damage | Hebbel et al40 |
| Increased age | Adelman and Figueroa41 |
| Clonal hematopoiesis | Pincez et al25 |