Most frequent BCP-ALL subtypes in AYA
| Entity . | Description . | Prevalence (AYA) . | Prognosis . |
|---|---|---|---|
| BCR::ABL1 | t(9;22)(q34;q11) | 5%-20% | Int |
| Ph-like | 1) Jak/STAT activation (CRLF2-r) | 25%-30% | Unf |
| 2) ABL-class fusions | |||
| 3) Others (NTRK3-, FGFR1-, FLT3-, TYK2-r) | |||
| Hyperdiploid | 51-67 chr. | 11% | Fav |
| Hypodiploid | Low: 32-39 chr | 10%-15% | Unf |
| Near haploid: 24-31 chr | <3% | Unf | |
| KMT2A-r | t(v;11q23.3) | 8% | Unf |
| DUX4-r | Associated with ERG deletion | 8% | Fav |
| PAX5alt | Diverse PAX5 alterations | 8% | Int |
| PAX5-P80R | Biallelic alterations | 5% | Fav |
| iAMP21 | Intrachromosomic amplification | <5% | Unf |
| ZNF384-r | partner genes: EP300, TCF3, CREBBP | <5% | Int |
| MEF2D-r | partner genes: BCL9, HNRNPUL1 | <5% | Unf |
| TCF3::PBX1 | t(1;19)(q23;p13.3) | <5% | Int |
| ETV6::RUNX1 | t(12;21) (p12;q22) | <5% | Fav |
| MYC-r/BCL2-r | <5% | Unf | |
| CDX2/UBTF::ATXN7L3 | CDX2 cis-deregulation | <5% | Unf |
| TCF3::HLF | t(17;19)(q22;p13) | <1% | Unf |
| IGH::IL3 | t(5;14)(q31.1;q32.3) | <1% | Unf |
| Entity . | Description . | Prevalence (AYA) . | Prognosis . |
|---|---|---|---|
| BCR::ABL1 | t(9;22)(q34;q11) | 5%-20% | Int |
| Ph-like | 1) Jak/STAT activation (CRLF2-r) | 25%-30% | Unf |
| 2) ABL-class fusions | |||
| 3) Others (NTRK3-, FGFR1-, FLT3-, TYK2-r) | |||
| Hyperdiploid | 51-67 chr. | 11% | Fav |
| Hypodiploid | Low: 32-39 chr | 10%-15% | Unf |
| Near haploid: 24-31 chr | <3% | Unf | |
| KMT2A-r | t(v;11q23.3) | 8% | Unf |
| DUX4-r | Associated with ERG deletion | 8% | Fav |
| PAX5alt | Diverse PAX5 alterations | 8% | Int |
| PAX5-P80R | Biallelic alterations | 5% | Fav |
| iAMP21 | Intrachromosomic amplification | <5% | Unf |
| ZNF384-r | partner genes: EP300, TCF3, CREBBP | <5% | Int |
| MEF2D-r | partner genes: BCL9, HNRNPUL1 | <5% | Unf |
| TCF3::PBX1 | t(1;19)(q23;p13.3) | <5% | Int |
| ETV6::RUNX1 | t(12;21) (p12;q22) | <5% | Fav |
| MYC-r/BCL2-r | <5% | Unf | |
| CDX2/UBTF::ATXN7L3 | CDX2 cis-deregulation | <5% | Unf |
| TCF3::HLF | t(17;19)(q22;p13) | <1% | Unf |
| IGH::IL3 | t(5;14)(q31.1;q32.3) | <1% | Unf |
Fav, favorable; Int, intermediate; Unf, unfavorable.