Treatment-emergent AEs occurring in 10% or more of the patients (n = 25)
| AE . | Total . | Grade 1-2 . | Grade 3-4 . |
|---|---|---|---|
| Decreased platelet count | 18 (72) | 6 (24) | 12 (48) |
| Decreased neutrophil count | 17 (68) | 7 (28) | 10 (40) |
| Nausea | 17 (68) | 15 (60) | 2 (8) |
| Hyperglycemia | 15 (60) | 14 (56) | 1 (4) |
| Anemia | 14 (56) | 10 (40) | 4 (16) |
| Fatigue | 14 (56) | 13 (52) | 1 (4) |
| Decreased lymphocyte count | 13 (52) | 5 (20) | 8 (32) |
| Diarrhea | 12 (48) | 12 (48) | — |
| Constipation | 12 (48) | 12 (48) | — |
| Vomiting | 12 (48) | 10 (40) | 2 (8) |
| Hypoalbuminemia | 11 (44) | 11 (44) | — |
| Anorexia | 10 (40) | 10 (40) | — |
| Increased creatinine | 10 (40) | 10 (40) | — |
| Fever | 8 (32) | 7 (28) | 1 (4) |
| Abdominal pain | 7 (28) | 6 (24) | 1 (4) |
| Upper respiratory infection | 7 (28) | 6 (24) | 1 (4) |
| Hypocalcemia | 7 (28) | 7 (28) | — |
| Headache | 6 (24) | 6 (24) | — |
| Weight loss | 6 (24) | 6 (24) | — |
| Hypophosphatemia | 6 (24) | 4 (16) | 2 (8) |
| Hyponatremia | 5 (20) | 5 (20) | — |
| Dysgeusia | 5 (20) | 5 (20) | — |
| Increased aspartate aminotransferase | 5 (20) | 5 (20) | 1 (4) |
| Hypokalemia | 5 (20) | 5 (20) | — |
| Rash maculopapular | 4 (16) | 4 (16) | — |
| Increased blood bilirubin | 4 (16) | 2 (8) | 2 (8) |
| Urinary tract infection | 4 (16) | 3 (12) | 1 (4) |
| Cough | 4 (16) | 4 (16) | — |
| Chronic kidney disease | 4 (16) | 4 (16) | — |
| Malaise | 3 (12) | 3 (12) | — |
| Nasal congestion | 3 (12) | 3 (12) | — |
| Hypoglycemia | 3 (12) | 3 (12) | — |
| Hypercalcemia | 3 (12) | 3 (12) | — |
| Increased alanine aminotransferase | 3 (12) | 2 (8) | 1 (4) |
| Hypernatremia | 3 (12) | 3 (12) | — |
| Myalgia | 3 (12) | 3 (12) | — |
| Peripheral sensory neuropathy | 3 (12) | 3 (12) | — |
| Edema in the limbs | 3 (12) | 3 (12) | — |
| Dizziness | 3 (12) | 3 (12) | — |
| Arthralgia | 3 (12) | 3 (12) | — |
| Febrile neutropenia | 3 (12) | — | 3 (12) |
| Dyspepsia | 3 (12) | 3 (12) | — |
| Back pain | 3 (12) | 3 (12) | — |
| AE . | Total . | Grade 1-2 . | Grade 3-4 . |
|---|---|---|---|
| Decreased platelet count | 18 (72) | 6 (24) | 12 (48) |
| Decreased neutrophil count | 17 (68) | 7 (28) | 10 (40) |
| Nausea | 17 (68) | 15 (60) | 2 (8) |
| Hyperglycemia | 15 (60) | 14 (56) | 1 (4) |
| Anemia | 14 (56) | 10 (40) | 4 (16) |
| Fatigue | 14 (56) | 13 (52) | 1 (4) |
| Decreased lymphocyte count | 13 (52) | 5 (20) | 8 (32) |
| Diarrhea | 12 (48) | 12 (48) | — |
| Constipation | 12 (48) | 12 (48) | — |
| Vomiting | 12 (48) | 10 (40) | 2 (8) |
| Hypoalbuminemia | 11 (44) | 11 (44) | — |
| Anorexia | 10 (40) | 10 (40) | — |
| Increased creatinine | 10 (40) | 10 (40) | — |
| Fever | 8 (32) | 7 (28) | 1 (4) |
| Abdominal pain | 7 (28) | 6 (24) | 1 (4) |
| Upper respiratory infection | 7 (28) | 6 (24) | 1 (4) |
| Hypocalcemia | 7 (28) | 7 (28) | — |
| Headache | 6 (24) | 6 (24) | — |
| Weight loss | 6 (24) | 6 (24) | — |
| Hypophosphatemia | 6 (24) | 4 (16) | 2 (8) |
| Hyponatremia | 5 (20) | 5 (20) | — |
| Dysgeusia | 5 (20) | 5 (20) | — |
| Increased aspartate aminotransferase | 5 (20) | 5 (20) | 1 (4) |
| Hypokalemia | 5 (20) | 5 (20) | — |
| Rash maculopapular | 4 (16) | 4 (16) | — |
| Increased blood bilirubin | 4 (16) | 2 (8) | 2 (8) |
| Urinary tract infection | 4 (16) | 3 (12) | 1 (4) |
| Cough | 4 (16) | 4 (16) | — |
| Chronic kidney disease | 4 (16) | 4 (16) | — |
| Malaise | 3 (12) | 3 (12) | — |
| Nasal congestion | 3 (12) | 3 (12) | — |
| Hypoglycemia | 3 (12) | 3 (12) | — |
| Hypercalcemia | 3 (12) | 3 (12) | — |
| Increased alanine aminotransferase | 3 (12) | 2 (8) | 1 (4) |
| Hypernatremia | 3 (12) | 3 (12) | — |
| Myalgia | 3 (12) | 3 (12) | — |
| Peripheral sensory neuropathy | 3 (12) | 3 (12) | — |
| Edema in the limbs | 3 (12) | 3 (12) | — |
| Dizziness | 3 (12) | 3 (12) | — |
| Arthralgia | 3 (12) | 3 (12) | — |
| Febrile neutropenia | 3 (12) | — | 3 (12) |
| Dyspepsia | 3 (12) | 3 (12) | — |
| Back pain | 3 (12) | 3 (12) | — |
Data are no. (%).