Univariate analysis of time to next treatment in patients with CLL who are on ibrutinib
| Parameter . | Status . | Total . | Events . | % . | Mean . | SE . | 95% CI . | P . |
|---|---|---|---|---|---|---|---|---|
| sIgM MFI | Low | 26 | 2 | 92 | 76.5 | 2.3 | 72.1-80.9 | .008 |
| High | 44 | 16 | 63 | 58.1 | 4.3 | 49.6-66.6 | ||
| sIgM iCa2+ | Low | 31 | 4 | 87 | 73.2 | 3.2 | 70.0-79.3 | .022 |
| High | 39 | 14 | 63 | 57.9 | 4.7 | 48.8-67.1 | ||
| IGHV status | Mutated | 21 | 3 | 86 | 70.5 | 5 | 60.5-80.4 | .296 |
| Unmutated | 48 | 14 | 71 | 63.4 | 3.8 | 56.0-70.7 | ||
| B2M | Low | 39 | 14 | 64 | 58.9 | 4.5 | 50.1-67.6 | .084 |
| High | 16 | 2 | 88 | 72.4 | 5.1 | 62.4-82.4 | ||
| LDH | Low | 56 | 14 | 75 | 66.0 | 3.2 | 59.7-72.4 | .69 |
| High | 12 | 3 | 75 | 62.9 | 8.5 | 46.2-79.6 | ||
| CD38 | <30% | 38 | 9 | 76 | 64.8 | 4.3 | 56.4-73.1 | .907 |
| ≥30% | 30 | 9 | 70 | 63.8 | 4.7 | 54.6-73.0 | ||
| ZAP70 | <20% | 43 | 13 | 70 | 62.0 | 4.1 | 53.9-70.1 | .342 |
| ≥20% | 24 | 5 | 79 | 68.1 | 4.8 | 58.7-70.5 | ||
| CD49d | <30% | 27 | 11 | 59 | 58.8 | 5.1 | 48.8-68.7 | .071 |
| ≥30% | 36 | 6 | 83 | 70.1 | 3.7 | 62.8-77.3 | ||
| 17p13/TP53 | Wt | 61 | 15 | 76 | 66.2 | 3.2 | 59.8-72.5 | .099 |
| Mut/del | 9 | 3 | 67 | 57.4 | 8.1 | 41.6-73.2 |
| Parameter . | Status . | Total . | Events . | % . | Mean . | SE . | 95% CI . | P . |
|---|---|---|---|---|---|---|---|---|
| sIgM MFI | Low | 26 | 2 | 92 | 76.5 | 2.3 | 72.1-80.9 | .008 |
| High | 44 | 16 | 63 | 58.1 | 4.3 | 49.6-66.6 | ||
| sIgM iCa2+ | Low | 31 | 4 | 87 | 73.2 | 3.2 | 70.0-79.3 | .022 |
| High | 39 | 14 | 63 | 57.9 | 4.7 | 48.8-67.1 | ||
| IGHV status | Mutated | 21 | 3 | 86 | 70.5 | 5 | 60.5-80.4 | .296 |
| Unmutated | 48 | 14 | 71 | 63.4 | 3.8 | 56.0-70.7 | ||
| B2M | Low | 39 | 14 | 64 | 58.9 | 4.5 | 50.1-67.6 | .084 |
| High | 16 | 2 | 88 | 72.4 | 5.1 | 62.4-82.4 | ||
| LDH | Low | 56 | 14 | 75 | 66.0 | 3.2 | 59.7-72.4 | .69 |
| High | 12 | 3 | 75 | 62.9 | 8.5 | 46.2-79.6 | ||
| CD38 | <30% | 38 | 9 | 76 | 64.8 | 4.3 | 56.4-73.1 | .907 |
| ≥30% | 30 | 9 | 70 | 63.8 | 4.7 | 54.6-73.0 | ||
| ZAP70 | <20% | 43 | 13 | 70 | 62.0 | 4.1 | 53.9-70.1 | .342 |
| ≥20% | 24 | 5 | 79 | 68.1 | 4.8 | 58.7-70.5 | ||
| CD49d | <30% | 27 | 11 | 59 | 58.8 | 5.1 | 48.8-68.7 | .071 |
| ≥30% | 36 | 6 | 83 | 70.1 | 3.7 | 62.8-77.3 | ||
| 17p13/TP53 | Wt | 61 | 15 | 76 | 66.2 | 3.2 | 59.8-72.5 | .099 |
| Mut/del | 9 | 3 | 67 | 57.4 | 8.1 | 41.6-73.2 |
Wt, wild type; Mut/del, mutated and/or deleted.